کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5648201 | 1587502 | 2016 | 7 صفحه PDF | دانلود رایگان |
BackgroundPyoderma gangrenosum is a rare inflammatory skin condition. Two prospective studies have evaluated treatments for pyoderma gangrenosum using a primary outcome of healing speed at 6Â weeks.ObjectiveUsing data from both studies we assessed the predictive value of 3 early predictors for healing at 6Â months: speed of healing, Investigator Global Assessment (IGA), and resolution of inflammation, recorded at 2 and 6Â weeks.MethodsLogistic regression models were applied and the effectiveness of the 3 measures was assessed through estimating the positive and negative predictive values and the area under the receiver operating characteristic curve.ResultsThe positive and negative predictive value at 6Â weeks were, respectively, 63.5% (95% confidence interval [CI] 52.4%-73.7%) and 74.6% (95% CI 62.5%-84.5%) for speed of healing; 80% (95% CI 68.7%-88.6%) and 74.2% (95% CI 64.1%-82.7%) for IGA; and 72.1% (95% CI 59.9%-82.3%) and 68.1% (95% CI 57.7%-77.3%) for resolution of inflammation. IGA had the best combined positive predictive value, negative predictive value, and area under the receiver operating characteristic curve at 2 and 6Â weeks.LimitationsWe were limited by data available from existing datasets.ConclusionSpeed of healing, IGA, and resolution of inflammation were all shown to be good predictors of eventual healing of pyoderma gangrenosum.
Journal: Journal of the American Academy of Dermatology - Volume 75, Issue 6, December 2016, Pages 1216-1220.e2