کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5649514 | 1407126 | 2017 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of Atopic Dermatitis with Cardiovascular Risk Factors and Diseases
ترجمه فارسی عنوان
انجمن درماتیت آتوپیک با عوامل خطر بیماری قلبی عروقی
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کلمات کلیدی
CVRFAngina pectoris - آنژین پکتیکسPeripheral arterial disease - بیماری شریانی محیطیcoronary artery disease - بیماری عروق کرونرcardiovascular disease - بیماری قلب و عروقیCooperative Health Research in the Region of Augsburg - تحقیقات بهداشت همگانی در منطقه آگسبورگAtopic dermatitis - درماتیت آتوپیکICD - دفیبریلاتورهای کاردیوورتر کاشتنیCVD - رسوب دهی شیمیایی بخار body mass index - شاخص توده بدنBMI - شاخص توده بدنیCAD - طراحی به کمک رایانه یا کَدCardiovascular risk factor - فاکتور ریسک قلب و عروقGenome-wide association study - مطالعه مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومPAD - پدKORA - کورا
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
چکیده انگلیسی
Epidemiological studies suggested an association between atopic dermatitis (AD) and cardiovascular disease. Therefore, we investigate associations and potential underlying pathways of AD and cardiovascular disease in large cohort studies: the AOK PLUS cohort (n = 1.2 Mio), the GINIplus/LISAplus birth cohorts (n = 2,286), and the Cooperative Health Research in the Region of Augsburg (KORA) F4 cohort (n = 2,990). In addition, metabolomics in KORA F4 and established cardiovascular risk loci in genome-wide data on 10,788 AD cases and 30,047 controls were analyzed. Longitudinal analysis of patients with AD in AOK PLUS showed slightly increased risk for incident angina pectoris (adjusted risk ratio 1.17 [95% confidence interval 1.12-1.23]), hypertension (1.04 [1.02-1.06]), and peripheral arterial disease (1.15 [1.11-1.19]) but not for myocardial infarction (1.05 [0.99-1.12]) and stroke (1.02 [0.98-1.07]). In KORA F4 and GINIplus/LISAplus, AD was not associated with cardiovascular risk factors and no differences in metabolite levels were detected. There was no robust evidence for shared genetic risk variants of AD and cardiovascular disease. This study indicates only a marginally increased risk for angina pectoris, hypertension, and peripheral arterial disease and no increased risk for myocardial infarction or stroke in patients with AD. Relevant associations of AD with cardiovascular risk factors reported in US populations could not be confirmed. Likewise, patients with AD did not have increased genetic risk factors for cardiovascular disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 137, Issue 5, May 2017, Pages 1074-1081
Journal: Journal of Investigative Dermatology - Volume 137, Issue 5, May 2017, Pages 1074-1081
نویسندگان
Marie Standl, Falko Tesch, Hansjörg Baurecht, Elke RodrÃguez, Martina Müller-Nurasyid, Christian Gieger, Annette Peters, Rui Wang-Sattler, Cornelia Prehn, Jerzy Adamski, Florian Kronenberg, Holger Schulz, Sibylle Koletzko, Tamara Schikowski,