کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5823008 | 1117994 | 2010 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
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کلمات کلیدی
GTPGTaseCCHFVCSFVBVDVdsRNARSVNLSHBSIMPLBSGMPHelicaseCPEinosine 5′-monophosphate - 5 "منوفسفات inosinedouble-stranded RNA - RNA دو رشته ایRNA-dependent RNA polymerase - RNA پلیمراز وابسته به RNANuclear localization sequences - توالی های محلی سازی هسته ایendoplasmic reticulum - شبکه آندوپلاسمی Non-structural - غیر ساختاریMethyltransferase - متیل ترانسفرازHCV - هپاتیت سیHepatitis C virus - هپاتیت سیbovine viral diarrhea virus - ویروس اسهال ویروسی گاوRespiratory syncytial virus - ویروس سنسیتیال تنفسیCrimean-Congo Hemorrhagic Fever Virus - ویروس قلمرو هموراژیک کریمه-کنگوHIV - ویروس نقص ایمنی انسانی Classical swine fever virus - ویروس کبد خوکProtease - پروتئازMembrane protein - پروتئین غشائیEnvelope protein - پروتئین پاکتcapsid protein - پروتئین کپسیدGuanosine monophosphate - گوئنوسین مونوفسفرهGuanosine triphosphate - گوانوزین تری فسفاتGuanylyltransferase - گویینیلترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA genome. Besides yellow fever virus, a landmark case in the history of virology, members of the Flavivirus genus, such as West Nile virus and dengue virus, are increasingly gaining attention due to their re-emergence and incidence in different areas of the world. Additional environmental and demographic considerations suggest that novel or known flaviviruses will continue to emerge in the future. Nevertheless, up to few years ago flaviviruses were considered low interest candidates for drug design. At the start of the European Union VIZIER Project, in 2004, just two crystal structures of protein domains from the flaviviral replication machinery were known. Such pioneering studies, however, indicated the flaviviral replication complex as a promising target for the development of antiviral compounds. Here we review structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex. Most of the reviewed results were achieved within the European Union VIZIER Project, and cover topics that span from viral genomics to structural biology and inhibition mechanisms. The ultimate aim of the reported approaches is to shed light on the design and development of antiviral drug leads.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 87, Issue 2, August 2010, Pages 125-148
Journal: Antiviral Research - Volume 87, Issue 2, August 2010, Pages 125-148
نویسندگان
Michela Bollati, Karin Alvarez, René Assenberg, Cécile Baronti, Bruno Canard, Shelley Cook, Bruno Coutard, Etienne Decroly, Xavier de Lamballerie, Ernest A. Gould, Gilda Grard, Jonathan M. Grimes, Rolf Hilgenfeld, Anna M. Jansson, Hélène Malet,