کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5823927 | 1118374 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dog bites man or man bites dog? The enigma of the amino acid conjugations
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کلمات کلیدی
mGluRNMDAREAATEAAAmino acid conjugationECFLPIGLNIAGECTIAAgPb4-Nitrobenzoic acidPAA2-Furoic acid - 2-فورئیک اسیدArginine - آرژنین excitatory amino acid - آمینو اسید هیجان انگیزArg - ارگ4-Aminobenzoic acid - اسید 4-آمینو بنزوئیکInhibitory amino acid - اسید آمینه مهاریPhenylacetic acid - اسید فینسیلیکHippuric acid - اسید هیپوریکglutamic acid - اسید گلوتامیکBenzoic acid - بنزوئیک اسیدTaurine - تائورینexcitatory amino acid transporter - حمل کننده آمینو اسید هیجان انگیزTau - خود راElectroconvulsive therapy - درمان با ضربه الکتریکی تشنجآور، الکتروشوک درمانیCNS - دستگاه عصبی مرکزیBBB - سد خونی مغزیcentral nervous system - سیستم عصبی مرکزیLysinuric protein intolerance - عدم تحمل پروتئین LysinuricBlood-brain barrier - مانع خون مغزیextracellular fluid - مایع خارج سلولیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراGlu - گلوglutamine - گلوتامینGly - گلیGlycine - گلیسینN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartateMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیکNaPBA - یکشنبه
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
The proposition posed is that the value of amino acid conjugation to the organism is not, as in the traditional view, to use amino acids for the detoxication of aromatic acids. Rather, the converse is more likely, to use aromatic acids that originate from the diet and gut microbiota to assist in the regulation of body stores of amino acids, such as glycine, glutamate, and, in certain invertebrates, arginine, that are key neurotransmitters in the central nervous system (CNS). As such, the amino acid conjugations are not so much detoxication reactions, rather they are homeostatic and neuroregulatory processes. Experimental data have been culled in support of this hypothesis from a broad range of scientific and clinical literature. Such data include the low detoxication value of amino acid conjugations and the Janus nature of certain amino acids that are both neurotransmitters and apparent conjugating agents. Amino acid scavenging mechanisms in blood deplete brain amino acids. Amino acids glutamate and glycine when trafficked from brain are metabolized to conjugates of aromatic acids in hepatic mitochondria and then irreversibly excreted into urine. This process is used clinically to deplete excess nitrogen in cases of urea cycle enzymopathies through excretion of glycine or glutamine as their aromatic acid conjugates. Untoward effects of high-dose phenylacetic acid surround CNS toxicity. There appears to be a relationship between extent of glycine scavenging by benzoic acid and psychomotor function. Glycine and glutamine scavenging by conjugation with aromatic acids may have important psychosomatic consequences that link diet to health, wellbeing, and disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 83, Issue 10, 15 May 2012, Pages 1331-1339
Journal: Biochemical Pharmacology - Volume 83, Issue 10, 15 May 2012, Pages 1331-1339
نویسندگان
Diren BeyoÄlu, Robert L. Smith, Jeffrey R. Idle,