کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5859332 | 1132469 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute iron overload and oxidative stress in brain
ترجمه فارسی عنوان
اضافه بار آهن و استرس اکسیداتیو در مغز
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کلمات کلیدی
LIPNF-κBTBARSCATAH−α-TPBNdeferoxamine mesylateTGADMSO - DMSODNA - DNA یا اسید دزوکسی ریبونوکلئیکO2− - O2-ROS - ROSHydrogen peroxide - آب اکسیژنهAscorbate - آسکوربات یا ویتامین ثAlpha tocopherol - آلفا توکوفرولsuperoxide anion - آنیون سوپر اکسیدIron - آهنLabile iron pool - استخر چربDehydroascorbic acid - اسید Dehydroascorbicdeoxyribonucleic acid - اسید deoxyribonucleicOxygen - اکسیژنEPR - تشدید پارامغناطیس الکترونElectron paramagnetic resonance - تشدید پارامغناطیس الکترونOxidative stress - تنش اکسیداتیوDHA - دوکوساهگزائنوئیک اسیدDimethyl sulfoxide - دیمتیل سولفواکسیدFree radicals - رادیکال آزادAscorbyl radical - رادیکال اسکروبیلHydroxyl radical - رادیکال هیدروکسیلTEMPO - زمانSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازnuclear factor kappa B - فاکتور هسته ای کاپا BFerritin - فریتینBrain - مغزthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکH2O2 - هیدروژن پراکسیدCatalase - کاتالازCalcein - کلساینReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
An in vivo model in rat was developed by intraperitoneally administration of Fe-dextran to study oxidative stress triggered by Fe-overload in rat brain. Total Fe levels, as well as the labile iron pool (LIP) concentration, in brain from rats subjected to Fe-overload were markedly increased over control values, 6 h after Fe administration. In this in vivo Fe overload model, the ascorbyl (A)/ascorbate (AHâ) ratio, taken as oxidative stress index, was assessed. The A/AHâ ratio in brain was significantly higher in Fe-dextran group, in relation to values in control rats. Brain lipid peroxidation indexes, thiobarbituric acid reactive substances (TBARS) generation rate and lipid radical (LR) content detected by Electron Paramagnetic Resonance (EPR), in Fe-dextran supplemented rats were similar to control values. However, values of nuclear factor-kappaB deoxyribonucleic acid (NFκB DNA) binding activity were significantly increased (30%) after 8 h of Fe administration, and catalase (CAT) activity was significantly enhanced (62%) 21 h after Fe administration. Significant enhancements in Fe content in cortex (2.4 fold), hippocampus (1.6 fold) and striatum (2.9 fold), were found at 6 h after Fe administration. CAT activity was significantly increased after 8 h of Fe administration in cortex, hippocampus and striatum (1.4 fold, 86, and 47%, respectively). Fe response in the whole brain seems to lead to enhanced NF-κB DNA binding activity, which may contribute to limit oxygen reactive species-dependent damage by effects on the antioxidant enzyme CAT activity. Moreover, data shown here clearly indicate that even though Fe increased in several isolated brain areas, this parameter was more drastically enhanced in striatum than in cortex and hippocampus. However, comparison among the net increase in LR generation rate, in different brain areas, showed enhancements in cortex lipid peroxidation, without changes in striatum and hippocampus LR generation rate after 6 h of Fe overload. This information has potential clinical relevance, as it could be the key to understand specific brain damage occurring in conditions of Fe overload.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 314, Issue 1, 6 December 2013, Pages 174-182
Journal: Toxicology - Volume 314, Issue 1, 6 December 2013, Pages 174-182
نویسندگان
Natacha E. Piloni, Virginia Fermandez, Luis A. Videla, Susana Puntarulo,