کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6117113 | 1217165 | 2015 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monocyte chemoattractant protein-1 gene (MCP-1) polymorphisms are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study
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کلمات کلیدی
GEAT2DMMCP1ANCOVAGGTCACMyocardial infarction - آنفارکتوس میوکاردEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدAIMS - اهدافcoronary artery disease - بیماری عروق کرونرanalysis of covariance - تجزیه و تحلیل کوواریانسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceType 2 diabetes mellitus - دیابت نوع دوCAD - طراحی به کمک رایانه یا کَدLinkage disequilibrium - عدم تعادل پیوستگیAncestry informative markers - نشانگرهای رسمی اجدادیHaplotypes - هاپلوتیپpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازmonocyte chemoattractant protein - پروتئین شیمیایی monocyte chemoattractantPolymorphisms - پلی مورفیسمSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدCoronary artery calcification - کلسیفیکاسیون عروق کرونرgamma-glutamyl transpeptidase - گاما گلوتامیل ترانسپپتیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The CC chemokine monocyte chemoattractant protein (MCP)-1/CCL2 is involved in the formation, progression, and destabilization of atheromatous plaques and plays an essential role in postinfarction remodeling. The aim of the present study was to evaluate the role of MCP-1 gene polymorphisms as susceptibility markers for premature coronary artery disease (CAD) and cardiovascular risk factors in the Mexican population. Four MCP-1 gene polymorphisms (rs1024611, rs2857654, rs3760396, and rs1024610) were genotyped by 5Ⲡexonuclease TaqMan assays in a group of 1072 patients with premature CAD, and 1082 healthy unrelated controls (with negative calcium score by computed tomography) seeking for associations with premature CAD and other metabolic and cardiovascular risk factors using logistic regression analyses. MCP-1 polymorphism frequencies were similar in premature CAD patients and healthy controls. When the analysis included only those premature CAD patients without type 2 diabetes mellitus (T2DM), the rs1024610 polymorphism was associated with increased risk of developing premature CAD under dominant and additive models adjusted by age and gender (OR = 1.33, Pdom = 0.040 and OR = 1.34, Padd = 0.027). The effect of the MCP-1 polymorphisms on various metabolic cardiovascular risk factors and metabolic parameters was explored separately in controls, and premature CAD. In this analysis adjusted by age and gender, the rs3760396 CC genotype was associated with low levels of gamma-glutamyl transpeptidase (P = 0.002), whereas, the rs1024610 TT genotype was associated with decreased risk of T2DM (P = 0.035) in premature CAD patients. One haplotype (CATG) was associated with increased risk of developing premature CAD (OR = 1.44, P = 0.0019). In summary, in our study, the rs1024610 polymorphism was associated with increased risk of developing premature CAD only in those patients without T2DM. The four MCP-1 polymorphisms were in high linkage disequilibrium and one haplotype was significantly associated with risk of developing premature CAD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 167, Issue 2, October 2015, Pages 125-130
Journal: Immunology Letters - Volume 167, Issue 2, October 2015, Pages 125-130
نویسندگان
Javier Angeles-MartÃnez, Rosalinda Posadas-Sánchez, Edith Álvarez-León, Teresa Villarreal-Molina, Guillermo Cardoso-Saldaña, José Manuel Fragoso, Juan Gabriel Juárez-Rojas, Aida Medina-Urrutia, Carlos Posadas-Romero, Gilberto Vargas-Alarcón,