کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6125852 | 1221032 | 2014 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Injury-induced immune responses in Hydra
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کلمات کلیدی
DEDcoiled coil domainPYDNF-ATANKNBDLRRAMPsAP1CREBNLRPRRCBPTLRPAMPENAHspNF-κBDAMPPTMNrf2NODBIR - BRECSIT - ECSIROS - ROSLast common ancestor - آخرین اجداد مشترکSTAT - آمارLCA - ارزیابی چرخه حیاتpost-translational modification - اصلاح post-translationalWound Healing - التیام زخمdamage-associated molecular pattern - الگوی مولکولی مرتبط با آسیبEuropean Nucleotide Archive - بایگانی هسته ای اروپاankyrin repeat - تکرار ankyrinToll-like receptor - تیالآرnucleotide binding domain - دامنه اتصال نوکلئوتیدیcaspase recruitment domain - دامنه استخدام کاسپسpyrin domain - دامنه را امتحان کنیدdeath effector domain - دامنه موثر مرگNACHT - شبNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهnuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استMAMP - مامانsignal transducers and activators of transcription - مبدل سیگنال و فعال کننده رونویسیHPA - میلی بار یا هکتوپاسکالCREB binding protein - پروتئین اتصال CREBcAMP response element binding protein - پروتئین اتصال دهنده عنصر پاسخ cAMPactivator protein-1 - پروتئین فعال کننده-1heat-shock protein - پروتئین گرمایی شوکAntimicrobial peptides - پپتیدهای پادمیکرب یا آنتیمایکروبیال پپتایدCARD - کارتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Injury-induced immune responses in Hydra Injury-induced immune responses in Hydra](/preview/png/6125852.png)
چکیده انگلیسی
The impact of injury-induced immune responses on animal regenerative processes is highly variable, positive or negative depending on the context. This likely reflects the complexity of the innate immune system that behaves as a sentinel in the transition from injury to regeneration. Early-branching invertebrates with high regenerative potential as Hydra provide a unique framework to dissect how injury-induced immune responses impact regeneration. A series of early cellular events likely require an efficient immune response after amputation, as antimicrobial defence, epithelial cell stretching for wound closure, migration of interstitial progenitors toward the wound, cell death, phagocytosis of cell debris, or reconstruction of the extracellular matrix. The analysis of the injury-induced transcriptomic modulations of 2636 genes annotated as immune genes in Hydra identified 43 genes showing an immediate/early pulse regulation in all regenerative contexts examined. These regulations point to an enhanced cytoprotection via ROS signaling (Nrf, C/EBP, p62/SQSMT1-l2), TNFR and TLR signaling (TNFR16-like, TRAF2l, TRAF5l, jun, fos-related, SIK2, ATF1/CREB, LRRC28, LRRC40, LRRK2), proteasomal activity (p62/SQSMT1-l1, Ced6/Gulf, NEDD8-conjugating enzyme Ubc12), stress proteins (CRYAB1, CRYAB2, HSP16.2, DnaJB9, HSP90a1), all potentially regulating NF-κB activity. Other genes encoding immune-annotated proteins such as NPYR4, GTPases, Swap70, the antiproliferative BTG1, enzymes involved in lipid metabolism (5-lipoxygenase, ACSF4), secreted clotting factors, secreted peptidases are also pulse regulated upon bisection. By contrast, metalloproteinases and antimicrobial peptide genes largely follow a context-dependent regulation, whereas the protease inhibitor α2macroglobulin gene exhibits a sustained up-regulation. Hence a complex immune response to injury is linked to wound healing and regeneration in Hydra.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 26, Issue 4, August 2014, Pages 277-294
Journal: Seminars in Immunology - Volume 26, Issue 4, August 2014, Pages 277-294
نویسندگان
Yvan Wenger, Wanda Buzgariu, Silke Reiter, Brigitte Galliot,