کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6326460 | 1619755 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Degradation of 5-FU by means of advanced (photo)oxidation processes: UV/H2O2, UV/Fe2Â +/H2O2 and UV/TiO2 - Comparison of transformation products, ready biodegradability and toxicity
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کلمات کلیدی
LBT5-FUClosed Bottle testOECDAOPBODESIDOCBBDHO• - HO •Hydrogen peroxide - آب اکسیژنهLuminescent bacteria test - آزمون باکتری لومینسنتQSAR - بزرگسال biochemical oxygen demand - بیوشیمیایی نیاز به اکسیژنanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancechemical oxygen demand - تقاضای اکسیژن شیمیاییQuantitative Structure Activity Relationship - رابطه فعالیت ساختاری کمیHydroxyl radicals - رادیکالهای هیدروکسیلCBT - رفتار درمانی شناختی Organization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیBox Behnken design - طراحی جعبه BehnkenMass spectrometry - طیف سنجی جرمیAdvanced oxidation process - فرایند اکسیداسیون پیشرفته5-fluorouracil - فلوروراسیل-۵، فلوئورواوراسیلDOM - قضاوتDissolved organic matter - ماده آلی حل شدهgrowth inhibition - مهار رشدChronic inhibition - مهار مزمنNanometers - نانومترH2O2 - هیدروژن پراکسیدCod - کادوDissolved organic carbon - کربن آلی حل شدهliquid chromatography - کروماتوگرافی مایعliquid chromatography tandem mass spectrometry - کروماتوگرافی مایع اسپکترومتری دو طرفهhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراCaP - کلاه لبه دارCapecitabine - کپسیتابینelectrospray ionization - یونیزاسیون الکترو اسپری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study investigates the degradation of the antimetabolite 5-fluorouracil (5-FU) by three different advanced photo oxidation processes: UV/H2O2, UV/Fe2Â +/H2O2 and UV/TiO2. Prescreening experiments varying the H2O2 and TiO2 concentrations were performed in order to set the best catalyst concentrations in the UV/H2O2 and UV/TiO2 experiments, whereas the UV/Fe2Â +/H2O2 process was optimized varying the pH, Fe2Â + and H2O2 concentrations by means of the Box-Behnken design (BBD). 5-FU was quickly removed in all the irradiation experiments. The UV/Fe2Â +/H2O2 and UV/TiO2 processes achieved the highest degree of mineralization, whereas the lowest one resulted from the UV/H2O2 treatment. Six transformation products were formed during the advanced (photo)oxidation processes and identified using low and high resolution mass spectrometry. Most of them were formed and further eliminated during the reactions. The parent compound of 5-FU was not biodegraded, whereas the photolytic mixture formed in the UV/H2O2 treatment after 256Â min showed a noticeable improvement of the biodegradability in the closed bottle test (CBT) and was nontoxic towards Vibrio fischeri. In silico predictions showed positive alerts for mutagenic and genotoxic effects of 5-FU. In contrast, several of the transformation products (TPs) generated along the processes did not provide indications for mutagenic or genotoxic activity. One exception was TP with m/z 146 with positive alerts in several models of bacterial mutagenicity which could demand further experimental testing. Results demonstrate that advanced treatment can eliminate parent compounds and its toxicity. However, transformation products formed can still be toxic. Therefore toxicity screening after advanced treatment is recommendable.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volumes 527â528, 15 September 2015, Pages 232-245
Journal: Science of The Total Environment - Volumes 527â528, 15 September 2015, Pages 232-245
نویسندگان
Carlos Alexandre Lutterbeck, Marcelo LuÃs Wilde, Ewelina Baginska, Christoph Leder, Ãnio Leandro Machado, Klaus Kümmerer,