کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6824676 | 548502 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in gene expression and methylation in the blood of patients with first-episode psychosis
ترجمه فارسی عنوان
تغییرات در بیان ژن و متیلاسیون در خون بیماران مبتلا به روان در اولین مرحله
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کلمات کلیدی
RELNSCIDPANSSGCH1actin, betaTSPOBH4GTP cyclohydrolase IReelinNRG1translocator protein (18 kDa)b2mHPRT1ABATFEPCHRNEGTP cyclohydrolase 1glutamic acid decarboxylase 67ribosomal protein L13AqPCRmRNACatechol-O-methyltransferaseHKGGAPDHBiopterinCOMTGad67RPL13A4-aminobutyrate aminotransferase - 4-آمینوبوتیرات آمینوترانسفرازSchizophrenia - اسکیزوفرنی یا شیزوفرنیribonucleic acid - اسید ریبونوکلئیکRNA - اسید ریبونوکلئیکgamma-aminobutyric acid - اسید گاما آمینو بوتیریکBeta-2-microglobulin - بتا-2-میکروگلوبولینGene expression - بیان ژنSerial analysis of gene expression - تجزیه و تحلیل سریال بیان ژنSAGE - حکیمmessenger ribonucleic acid - رسوب ریبونوکلئیک اسیدFirst-episode psychosis - روان درمانی اولActb - عملstructured clinical interview for DSM-IV - مصاحبه بالینی ساختاری برای DSM-IVpositive and negative syndrome scale - مقیاس مثبت و منفی سندرمneuregulin 1 - نورونگولین 1Hypoxanthine phosphoribosyltransferase 1 - هیپوکسانتین فسفریبوسیل ترانسفراز 1polymerase chain reaction - واکنش زنجیره ای پلیمرازquantitative polymerase chain reaction - واکنش زنجیره ای پلیمراز کمیPCR - واکنش زنجیرهٔ پلیمرازthreshold cycle - چرخه آستانهHousekeeping genes - ژن های خانه دارGABA - گاباglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Schizophrenia is a severe mental health disorder with high heritability. The investigation of individuals during their first-episode psychosis (FEP), before the progression of psychotic disorders and especially before treatment with antipsychotic medications, is particularly helpful for understanding this complex disease and for the identification of potential biomarkers. In this study, we compared the expression of genes that are involved in neurotransmission and neurodevelopment of antipsychotic-naive FEP in the peripheral blood of patients (n = 51) and healthy controls (n = 51). In addition, we investigated the differentially expressed genes with respect to a) DNA methylation, b) the correlation between gene expression and clinical variables (PANSS), and c) gene expression changes after risperidone treatment. Expression levels of 11 genes were quantified with SYBR Green. For methylation analysis, bisulfite sequencing was performed. A significant decrease in GCH1 mRNA levels was observed in FEP patients relative to controls. Also, when we compare the FEP patients after risperidone treatment with controls, this difference remains significant, and no significant differences were observed in GCH1 mRNA levels when comparing patients before and after risperidone treatment. Additionally, although the differences were non-significant after Bonferroni correction, the expression of GCH1 seemed to be correlated with PANSS scores, and the GCH1 promoter region was more methylated in FEP than in controls, thus corroborating the results obtained at the mRNA level. Few studies have been conducted on GCH1, and future studies are needed to clarify its potential role in the progression of schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 159, Issues 2â3, November 2014, Pages 358-364
Journal: Schizophrenia Research - Volume 159, Issues 2â3, November 2014, Pages 358-364
نویسندگان
Vanessa Kiyomi Ota, Cristiano Noto, Ary Gadelha, Marcos Leite Santoro, Leticia Maria Spindola, Eduardo Sauerbronn Gouvea, Roberta Sessa Stilhano, Bruno Bertolucci Ortiz, Patricia Natalia Silva, João Ricardo Sato, Sang Won Han, Quirino Cordeiro,