کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623065 | 1494541 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prunus mume Sieb. et Zucc. fruit ameliorates alcoholic liver injury in mice by inhibiting apoptosis and inflammation through oxidative stress
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کلمات کلیدی
DAPIsterol response element binding protein 1Neochlorogenic acidMDAHepatic apoptosisACC15-chloromethylfluorescein diacetateCMFDAPARPERKCGAFASNF-κBIL1Jnk4-HNE4-hydroxynonenalFITC4',6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولc-Jun N-terminal kinase - C-Jun N-terminal kinaseopa1 - grandpa1MAPK - MAPKROS - ROSAlcoholic liver injury - آسیب الکلی کبدیNatural antioxidant - آنتی اکسیدان طبیعیfatty acid synthase - اسید چرب سنتازChlorogenic acid - اسید کلروژنیکtriacylglycerol - تری آسیل گلیسرول TUNEL - تونلPME - شرکتهای کوچک و متوسطnuclear factor kappa B - فاکتور هسته ای کاپا Bfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتLipogenesis - لیپوژنزterminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling - مارک نهایی با نام dUTP تخصیص داده شده توسط ترمینال deoxynucleotidyl transferase استmalondialdehyde - مالون دی آلدهیدmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenpoly ADP ribose polymerase - پلی ADA ریبوز پلی مرازextracellular-signal-regulated kinase - کیناز تنظیم شده خارج سلولی سیگنالReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The effects of Prunus mume Sieb. et Zucc. extract (PME) on alcohol-induced liver injury were investigated. These functions of PME were linked to antioxidant activity that suppress lipogenesis in liver tissue, in part inhibiting activation of sterol response element binding protein-1 through ROS-mitogen-activated protein kinase signalling axis, and by suppressing hepatic apoptosis and inflammation through ROS-mediated p53 signalling pathway. Eight compounds and their structures in PME were also identified by LC-MS analysis, and chlorogenic acid (CGA) and neochlorogenic acid (NeoCGA) were validated using standard compounds by HPLC. The effects of CGA against cellular damage caused by alcohol-induced oxidative stress were confirmed using AML-12 cells. CGA significantly inhibited alcohol-induced apoptosis and MAPK activation in the cells. Moreover, antioxidant activities of CGA in the alcohol treatment were demonstrated regarding to cellular redox status and oxidative damage. These studies validated therapeutic value of PME in the prevention of alcoholic liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 135-148
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 135-148
نویسندگان
Jeong Hoon Pan, Ki Yong Lee, Jun Ho Kim, Hyeji Shin, Jin Hyup Lee, Young Jun Kim,