کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514306 | 1556505 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmaceutical Co-Crystal of Flufenamic Acid: Synthesis and Characterization of Two Novel Drug-Drug Co-Crystal
ترجمه فارسی عنوان
کریستال های دارویی فلوفنامیک اسید: سنتز و مشخص کردن دو کریستال جدید دارویی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DSCsc-XRDCNBFFAAPIPXRDnuclear magnetic resonance - رزونانس مغناطیسی هستهایEthenzamide - اتنزامیدflufenamic acid - اسید فلوفنامیکSolubility - انحلال پذیریNMR - تشدید مغناطیسی هستهای Stability - ثباتRelative humidity - رطوبت نسبیCrystal engineering - مهندسی کریستالActive Pharmaceutical Ingredient - مواد اولیه دارویی فعالHygroscopicity - هموگلوبینPowder X-Ray Diffraction - پراش اشعه ایکسSingle-crystal X-ray diffraction - پراش اشعه ایکس کریستالDifferential scanning calorimetry - کالریمتری روبشی افتراقیCo-crystal - کریستال
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Two novel pharmaceutical co-crystals of anti-inflammatory drug flufenamic acid (FFA) with 2-chloro-4-nitrobenzoic acid (CNB) and ethenzamide (ETZ) have been synthesized by solvent evaporation method as well as by solvent drop-assisted grinding method. The synthesized co-crystals were characterized thoroughly by various spectroscopic methods and crystal structures were determined by single-crystal x-ray diffraction technique. In FFA-CNB co-crystal, robust supramolecular acid-acid homosynthon was observed. FFA-ETZ co-crystal is formed via robust supramolecular acid-amide heterosynthon. In FTIR spectra, a significant shift in the carbonyl stretching frequency was observed for the co-crystals due to the presence of intermolecular hydrogen bond. 1H nuclear magnetic resonance study suggests the presence of hydrogen bond in the solution state of FFA-ETZ co-crystal; however, it was absent for FFA-CNB co-crystal. Solubility study in Millipore water revealed that the solubility of FFA is increased by 2-fold when it is in the form of FFA-CNB co-crystal and no increment in the solubility of FFA was observed in FFA-ETZ co-crystal. About 5-fold increment in the solubility of FFA was observed in both the co-crystals in 0.1 N HCl (pH 1) solution. The synthesized co-crystals were found to be non-hygroscopic at â¼75% relative humidity and stable for a period of 6 months at ambient temperature (â¼25°C).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 5, May 2017, Pages 1384-1390
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 5, May 2017, Pages 1384-1390
نویسندگان
Sunil Kumar Nechipadappu, Venkatadri Tekuri, Darshak R. Trivedi,