کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514757 | 1556511 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of Water and a Model Lipophilic Compound in Human Stratum Corneum by NMR Spectroscopy and Equilibrium Sorption
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کلمات کلیدی
PBS19Fnuclear magnetic resonance - رزونانس مغناطیسی هستهایdeionized water - آب یونیزه شدهTransdermal drug delivery - تحویل داروی ترانزیستورNMR - تشدید مغناطیسی هستهای Sorption - جذبSpin-lattice relaxation time - زمان آرام شدن اسپین-شبکهPartition coefficient - ضریب تقسیمNMR spectroscopy - طیف سنجی رزونانس مغناطیسی هستهFluorine - فلورینCorneocytes - قرنوسیت هاStratum corneum - لایه شاخی، استراتوم کورنئومPhosphate buffered saline solution - محلول نمک فسفات بافرProton - پروتونSkin - پوست
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The stratum corneum (SC) is the outermost skin layer in humans and other mammals and the primary barrier to water loss and environmental exposure to chemicals and microorganisms. It consists of flattened, keratin-filled corneocytes surrounded by well-organized lipid layers. Human SC at varying degrees of hydration with and without addition of a model lipophilic compound, 2-(trifluoromethyl) benzonitrile (TFMB), was studied using proton (1H) and fluorine (19F) nuclear magnetic resonance techniques. Proton spectral analyses revealed that water mainly occupies the corneocytes in agreement with prior studies. Observations from 19F spectral and spin-lattice relaxation time (T1) analyses showed that TFMB is primarily present in the lipids with small amounts in water, which is located within the corneocytes. This is consistent with TFMB sorption, which was measured in SC with and without lipid extraction. The presence of TFMB within the corneocytes supports the hypothesis that transcellular diffusion of a lipophilic compound like TFMB may contribute to SC permeation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 11, November 2016, Pages 3376-3386
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 11, November 2016, Pages 3376-3386
نویسندگان
Chandana Kodiweera, Wayne J. Romonchuk, Yuan Yang, Annette L. Bunge,