کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536991 | 1560925 | 2017 | 81 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease
ترجمه فارسی عنوان
تجزیه و تحلیل تنظیمات محصول طبیعی گیرنده های کانابینوئید در درمان بیماری های انسانی
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کلمات کلیدی
FAAHERKNOS2-AGmaglGPCRPLC2-arachidonoylglycerolABHD6PI3Kadenyl cyclaseΔ9-THCeCBsGTPγSGTPasesTHCVPhytocannabinoidsmTORCyPCOXCBDAEACBNcAMP - cAMPSynthetic cannabinoids - Canabinoids مصنوعیECs - EC هاG protein coupled receptor - G پروتئین همراه با پروتئینΔ9-Tetrahydrocannabinol - Δ9-تتراهیدروکانیابینولCyclic adenosine monophosphate - آدنوزین مونوفسفات Cycliccyclooxygenase - آنزیم سیکلواکسیژنازNeurodegenerative disorders - اختلالات نوروژنیکamyotrophic lateral sclerosis - اسکلروز جانبی آمیوتروفیکFatty acid amide hydrolase - اسید آمینه هیدرولاز اسید چربendocannabinoids - اندوکانبایوئید هاAlzheimer's disease - بیماری آلزایمرALS - بیماری اسکلروز جانبی آمیوتروفیکHuntington's disease - بیماری هانتینگتونParkinson's disease - بیماری پارکینسونCNS - دستگاه عصبی مرکزیBBB - سد خونی مغزیblood brain barrier - سد خونی مغزیCytochrome P450 - سیتوکروم پی۴۵۰endocannabinoid system - سیستم اندوکانبینیدcentral nervous system - سیستم عصبی مرکزیNatural products - فرآورده های طبیعیphospholipase C - فسفولیپاز Cmonoacylglycerol lipase - لیپاز monoacylglycerol لیپازNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازmammalian target of rapamycin - هدف پستانداران رپامایسینG proteins - پروتئین GCannabidiol - کانابیدیولcannabinol - کانابینولExtracellular regulated kinases - کیناز تنظیم شده خارج سلولیcannabinoid receptors - گیرنده های کانابینوئیدG protein-coupled receptor - گیرندههای جفتشونده با پروتئین جی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
The organized, tightly regulated signaling relays engaged by the cannabinoid receptors (CBs) and their ligands, G proteins and other effectors, together constitute the endocannabinoid system (ECS). This system governs many biological functions including cell proliferation, regulation of ion transport and neuronal messaging. This review will firstly examine the physiology of the ECS, briefly discussing some anomalies in the relay of the ECS signaling as these are consequently linked to maladies of global concern including neurological disorders, cardiovascular disease and cancer. While endogenous ligands are crucial for dispatching messages through the ECS, there are also commonalities in binding affinities with copious exogenous ligands, both natural and synthetic. Therefore, this review provides a comparative analysis of both types of exogenous ligands with emphasis on natural products given their putative safer efficacy and the role of Î9-tetrahydrocannabinol (Î9-THC) in uncovering the ECS. Efficacy is congruent to both types of compounds but noteworthy is the effect of a combination therapy to achieve efficacy without unideal side-effects. An example is Sativex that displayed promise in treating Huntington's disease (HD) in preclinical models allowing for its transition to current clinical investigation. Despite the in vitro and preclinical efficacy of Î9-THC to treat neurodegenerative ailments, its psychotropic effects limit its clinical applicability to treating feeding disorders. We therefore propose further investigation of other compounds and their combinations such as the triterpene, α,β-amyrin that exhibited greater binding affinity to CB1 than CB2 and was more potent than Î9-THC and the N-alkylamides that exhibited CB2 selective affinity; the latter can be explored towards peripherally exclusive ECS modulation. The synthetic CB1 antagonist, Rimonabant was pulled from commercial markets for the treatment of diabetes, however its analogue SR144528 maybe an ideal lead molecule towards this end and HU-210 and Org27569 are also promising synthetic small molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 180, December 2017, Pages 24-48
Journal: Pharmacology & Therapeutics - Volume 180, December 2017, Pages 24-48
نویسندگان
S. Badal, K.N. Smith, R. Rajnarayanan,