کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8707088 | 1586225 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: A systematic review with meta-analyses
ترجمه فارسی عنوان
استراتژی های کاهش ریسک دندانپزشکی برای استئوکرویس مرتبط با دارو فک در میان بیماران سرطانی: بررسی سیستماتیک با متاآنالیز
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کلمات کلیدی
MRONJONJPRGFSRERCTBPSRandomized controlled trial - آزمایش تصادفی کنترل شدهEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدMedication-related osteonecrosis of the jaw - استئوآرتریسم مربوط به داروها فکBisphosphonate-related osteonecrosis of the jaw - استئوآرکروز وابسته به بیسفسفونات فکOsteonecrosis of the jaw - استئوژنز فکExtraction - استخراجPreventive measures - اقدامات پیشگیرانهBRONJ - برونجBisphosphonates - بیس فسفوناتCancer patients - بیماران سرطانیIntravenous - داخل وریدیantiresorptive therapy - درمان ضدعفونی کنندهskeletal related events - رویدادهای مرتبط با اسکلتconfidence interval - فاصله اطمینانCAR - ماشینRisk ratio - نسبت خطرchimeric antigen receptor - گیرنده آنتی ژنهای کرومیک
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
The purpose of this systematic review with meta-analysis was to assess the effectiveness of dental interventions in preventing or reducing the incidence of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving antiresorptive therapy, compared to similar control groups receiving no intervention. Randomized controlled trials (RCT), case-controls and cohorts on cancer patients with primary outcome being the prevalence of MRONJ were included. Four electronic databases were searched (Cochrane Library, PubMed, EMBASE and Web of Science) up to February 12, 2018. A total of 409 abstracts were assessed and one case-control, one RCT and four cohort studies with 2332 cancer patients met our inclusion criteria. Risk of bias analysis followed Cochrane's handbook. Risk of bias was unclear for the case-control study and high risk for the RCT and all cohort studies. Five studies utilized preventive measures consisting of an initial examination and performing all necessary dental treatment before patients initiated antiresorptive therapy; one study used specialized post-extraction protocols utilizing plasma-rich in growth factors (PRGF) on cancer patients receiving antiresorptive therapy. Though dental preventive measures decreased MRONJ incidence by 77.3% in six studies with 2332 cancer patients (95% CIâ¯=â¯47.4-90.2%; pâ¯=â¯.001) compared to control groups, quality of the evidence was low due to high or unclear risk of bias and the observational nature of five of the included studies. In conclusion, high-quality long-term prospective large sample size studies are needed to confirm these results due to high risk of bias and heterogeneous interventions. No funding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 85, October 2018, Pages 15-23
Journal: Oral Oncology - Volume 85, October 2018, Pages 15-23
نویسندگان
Harry Karna, Jaime Gonzalez, Harveen S. Radia, Parish P. Sedghizadeh, Reyes Enciso,