کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8713155 | 1587103 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pathogenic and protective roles of B cells and antibodies in patients with chronic rhinosinusitis
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کلمات کلیدی
GPACRSwNPICOSBAFF-RTACICRSsNPCVIDB-cell activating factor of the TNF familygranulomatous polyangiitisEBI2CRSNF-κBsIgA - sAgAantibodies - آنتی بادی هاsecondary lymphoid organ - ارگان لنفاوی ثانویهslo - اسلوMucosal immunity - ایمنی مخاطیBAFF - بافautoimmunity - خودایمنیChronic rhinosinusitis with nasal polyps - رینو زیستی مزمن با پولیپ بینیChronic rhinosinusitis without nasal polyps - رینوویوزیت مزمن بدون پولیپ بینیChronic rhinosinusitis - رینویوزیت مزمنTLo - زمینB cells - سلول های Bnuclear factor κB - فاکتور هسته ای κBtransmembrane activator and calcium modulator and cyclophilin ligand interactor - فعال کننده ترانس مغناطیسی و مدولاتور کلسیم و واکنش لیگاند سیکلوفیلینGerminal center - مرکز ژرمینالAntibody deficiency - کمبود آنتی بادیImmunodeficiency - کمبود ایمنیCommon variable immunodeficiency - کمبود ایمنی متغیر مشترکInducible costimulator - کوتیزولاتور قابل انعطاف
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nose and sinuses that affects up to 12% of the population in Europe and the United States. This complex disease is likely driven by multiple environmental, genetic, and inflammatory mechanisms, and recent studies suggest that B cells might play a critical role in disease pathogenesis. B cells and their antibodies have undisputed roles in health and disease within the airway mucosae. Deficient or inadequate B-cell responses can lead to susceptibility to infectious disease in the nose, whereas excess antibody production, including autoantibodies, can promote damaging inflammation. Thus, patients with B-cell defects often have either chronic or recurrent acute infections, and this can be associated with nonpolypoid CRS. In contrast, many patients with CRS with nasal polyps, which is less likely to be driven by pathogens, have excess production of local immunoglobulins, including autoreactive antibodies. These B-cell responses activate complement in many patients and likely contribute to immunopathogenic responses. AÂ better understanding of the BÂ cell-associated mechanisms that drive disease in patients with CRS should be a high priority in the quest to understand the pathogenesis of this disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 141, Issue 5, May 2018, Pages 1553-1560
Journal: Journal of Allergy and Clinical Immunology - Volume 141, Issue 5, May 2018, Pages 1553-1560
نویسندگان
Bruce K. MD, MS, Anju T. MD, Robert P. PhD, Kathryn E. PhD,