کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8713968 | 1587110 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Global issues in allergy and immunology: Parasitic infections and allergy
ترجمه فارسی عنوان
مسائل جهانی در آلرژی و ایمونولوژی: عفونت انگلی و آلرژی
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کلمات کلیدی
TregTigeILC2ILCSPTFOXP3STHTotal IgE - IgE کلAsthma - آسمAllergy - آلِرژیEpidemiology - اپیدمیولوژی(همهگیرشناسی)Skin prick test - تست خراش پوستیSoil-transmitted helminth - خاک کوهی منتقل می شودExcretory-secretory - دفع کننده-دفع کنندهinnate lymphoid cell - سلول لنفاوی ذاتیParasite infection - عفونت انگلیalternatively activated macrophage - ماکروفاژ فعال متناوبGenome-wide association study - مطالعه مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومRegulatory T - مقررات Ttype 2 innate lymphoid cell - نوع 2 سلول های لنفاوی ذاتیHelminths - هلمینت هاPathogenesis - پاتونزforkhead box protein 3 - پروتکل جعبه جعبه 3Single nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Allergic diseases are on the increase globally in parallel with a decrease in parasitic infection. The inverse association between parasitic infections and allergy at an ecological level suggests a causal association. Studies in human subjects have generated a large knowledge base on the complexity of the interrelationship between parasitic infection and allergy. There is evidence for causal links, but the data from animal models are the most compelling: despite the strong type 2 immune responses they induce, helminth infections can suppress allergy through regulatory pathways. Conversely, many helminths can cause allergic-type inflammation, including symptoms of “classical” allergic disease. From an evolutionary perspective, subjects with an effective immune response against helminths can be more susceptible to allergy. This narrative review aims to inform readers of the most relevant up-to-date evidence on the relationship between parasites and allergy. Experiments in animal models have demonstrated the potential benefits of helminth infection or administration of helminth-derived molecules on chronic inflammatory diseases, but thus far, clinical trials in human subjects have not demonstrated unequivocal clinical benefits. Nevertheless, there is sufficiently strong evidence to support continued investigation of the potential benefits of helminth-derived therapies for the prevention or treatment of allergic and other inflammatory diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 140, Issue 5, November 2017, Pages 1217-1228
Journal: Journal of Allergy and Clinical Immunology - Volume 140, Issue 5, November 2017, Pages 1217-1228
نویسندگان
Alvaro A. MD, Philip J. MD, PhD, Camila A. PhD, Neuza M. MD, PhD, Laura C. MD, PhD, Mauricio L. MD, PhD,