کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8713970 | 1587110 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic rhinosinusitis in Asia
ترجمه فارسی عنوان
رینویوزیت مزمن در آسیا
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CRSCRSwNPCRSsNPendotype - EndotypeEET - خوردنChronic rhinosinusitis with nasal polyps - رینو زیستی مزمن با پولیپ بینیChronic rhinosinusitis without nasal polyps - رینوویوزیت مزمن بدون پولیپ بینیChronic rhinosinusitis - رینویوزیت مزمنPhenotype - فنوتیپGenome-wide association study - مطالعه مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومtype 2 inflammation - نوع 2 التهابNasal polyps - پولیپ بینی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Chronic rhinosinusitis (CRS), although possibly overdiagnosed, is associated with a high burden of disease and is often difficult to treat in those truly affected. Recent research has demonstrated that inflammatory signatures of CRS vary around the world, with less eosinophilic and more neutrophilic inflammation found in Asia compared with Europe and North America. Although in the Western world about 80% of nasal polyps carry a type 2 signature, this might be between 20% and 60% in China and Korea or Thailand, respectively. These differences are associated with a lower asthma comorbidity and risk of disease recurrence after surgery in the Asian population. As a hallmark of severe type 2 inflammation, eosinophils attacking Staphylococcus aureus at the epithelial barrier have been described recently; they also can be found in a subgroup of Asian patients with nasal polyps. Furthermore, the percentage of type 2 signature disease in patients with CRS is dramatically increasing (“eosinophilic shift”) in several Asian countries over the last 20Â years. Establishing an accurate diagnosis along with considering the current and shifting patterns of inflammation seen in Asia will enable more effective selection of appropriate pharmacotherapy, surgical therapy, and eventually biotherapy. Determining the causes and pathophysiology for this eosinophilic shift will require additional research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 140, Issue 5, November 2017, Pages 1230-1239
Journal: Journal of Allergy and Clinical Immunology - Volume 140, Issue 5, November 2017, Pages 1230-1239
نویسندگان
Yuan MD, PhD, Elien PhD, Hongfei MD, PhD, Xiangdong MD, PhD, Luo MD, PhD, Claus MD, PhD, Nan MD, PhD,