Keratinocyte-derived, CD80-mediated costimulation is associated with hapten-specific IgE production during contact hypersensitivity to TH1 haptens

These data suggest that keratinocyte-derived costimulation mediated by B7-1 but not B7-2 results in the emergence of TH2-lymphocyte immune responses to TH1 haptens. Because human keratinocytes have been noted to express B7-1-like molecules in certain inflammatory skin diseases, this model may be important in understanding the pathophysiology of TH2-lymphocyte-mediated skin diseases such as atopic dermatitis.