کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9227425 | 1202040 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adipose tissue, adipokines, and inflammation
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کلمات کلیدی
NF-κBFIZZPBEFPre-B-cell colony-enhancing factorresistin-like moleculeRelmMCP-1IBDICAM-1Adipokines - آدیپوکین هاRheumatoid arthritis - آرتریتروماتوئیدinflammation - التهاب( توروم) Adipose tissue - بافت چربیWhite adipose tissue - بافت چربی سفیدcardiovascular disease - بیماری قلب و عروقیInflammatory bowel disease - بیماریهای التهابی رودهfound in inflammatory zone - در ناحیه التهابی یافت می شودCVD - رسوب دهی شیمیایی بخار Cytokines - سیتوکین هاbody mass index - شاخص توده بدنBMI - شاخص توده بدنیnuclear factor κB - فاکتور هسته ای κBObesity - مرض چاقیImmunity - مصونیتInsulin resistance - مقاومت به انسولینintracellular adhesion molecule 1 - مولکول چسبندگی داخل سلولی 1monocyte chemoattractant protein 1 - پروتئین cheoattractant monocyte 1C-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی WAT - چی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
White adipose tissue is no longer considered an inert tissue mainly devoted to energy storage but is emerging as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation. Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-α, IL-6, monocyte chemoattractant protein 1, and others. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 115, Issue 5, May 2005, Pages 911-919
Journal: Journal of Allergy and Clinical Immunology - Volume 115, Issue 5, May 2005, Pages 911-919
نویسندگان
Giamila PhD,