کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9262897 | 1215811 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways
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کلمات کلیدی
ERADVIPRHCMVHSVPLCβ2MVCPER-Associated Degradation - تخریب ER-Associatedtransporter associated with antigen processing - حمل کننده همراه با پردازش آنتی ژنheavy chain - زنجیره سنگینHuman cytomegalovirus - سیتومگالوویروس انسانیendoplasmic reticulum - شبکه آندوپلاسمی TAP - ضربه زدنpeptide-loading complex - مجتمع پپتید بارگذاریBeta-2 microglobulin - میکروگلوبولین بتا-2herpes simplex virus - ویروس هرپس سیمپلکسValosin-containing protein - پروتئین حاوی والوسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways](/preview/png/9262897.png)
چکیده انگلیسی
The CD8+ cytotoxic-T-cell response is a potent mechanism that controls intracellular pathogens, including many viruses. To facilitate transmission, viruses often counter this response by inhibiting the cell surface display of virus-derived peptides on MHC class I molecules. More specifically, recent studies have demonstrated that viruses have evolved remarkable mechanisms to inhibit MHC class I expression by interfering with the function of the MHC class I assembly machinery (the peptide-loading complex) in the endoplasmic reticulum and/or by exploiting endoplasmic-reticulum-associated degradation pathways. These viral molecules are proving invaluable as research tools to illuminate the novel features of physiological pathways that are central to normal cell biology. Furthermore, the detailed characterization of such pathways has yielded significant new insights into host-pathogen interplay.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 71-78
Journal: Current Opinion in Immunology - Volume 17, Issue 1, February 2005, Pages 71-78
نویسندگان
Lonnie Lybarger, Xiaoli Wang, Michael Harris, Ted H Hansen,