دانلود مقالات ISI درباره پپتید آمیلیید ب + ترجمه فارسی

Neuroscience Forefront ReviewSeizures in Alzheimer's disease

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; AD; Alzheimer's disease; AICD; APP intracellular domain; APP; Amyloid precursor protein; CAA; Cerebral amyloid angiopathy; CTFα; α C-terminal fragment; CTFβ; β C-terminal fragment; DS; Down syndrome; EEG; Electroencephalogra

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion

Keywords: پپتید آمیلیید ب; Aβ peptide; amyloid-β peptide; AD; Alzheimer׳s disease; APP-CTF; C-terminal fragment of β-amyloid precursor protein; BFA; brefeldin A; βAPP; β-amyloid precursor protein; COP; coatmer protein; ER; endoplasmic reticulum; CHX; cyloheximide; CPA; cyclop

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Neuroscience Forefront ReviewHemichannels: New pathways for gliotransmitter release

Keywords: پپتید آمیلیید ب; AD; Alzheimer's disease; APP; amyloid-β precursor protein; Aβ; amyloid-β peptide; BBB; blood-brain barrier; BLA; basolateral amygdala; CBX; carbenoxolone; CM; conditioned media; [Ca2+]e; extracellular Ca2+ concentrations; [Ca2+]i; intracellular Ca2

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Astrocytes regulate α-secretase-cleaved soluble amyloid precursor protein secretion in neuronal cells: Involvement of group IIA secretory phospholipase A2

Keywords: پپتید آمیلیید ب; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BACE1; β-site APP cleaving enzyme; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; FCVJ; Farne

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2015 سفارش ترجمه

Mitochondrial import and degradation of amyloid-β peptide

Keywords: پپتید آمیلیید ب; Mitochondria; Amyloid-β peptide; MAM; Degradation; Presequence protease; PreP;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations

Keywords: پپتید آمیلیید ب; APP; amyloid precursor protein; Aβ; amyloid-β peptide; AICD; amyloid precursor protein intracellular domain; AD; Alzheimer disease; FAD; familial AD; TMD; transmembrane domains; PS; presenilin; NTF; N-terminal fragment; CTF; C-terminal fragment; ER; end

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

Keywords: پپتید آمیلیید ب; AMPK; AMP-activated protein kinase; STAT; activator of transcription; AGE; advanced glycation end products; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACE; angiotensin converting enzyme; Ang I; angiotensin I; AR-II;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2014 سفارش ترجمه

S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans

Keywords: پپتید آمیلیید ب; AD; Alzheimer disease; Aβ; amyloid-β peptide; BCNU; 1,3-bis-(2-chloroethyl)-1-nitrosourea; GSH ethyl ester; C-terminal glycine of GSH; DMSO; dimethyl sulfoxide; PBS; phosphate-buffered saline; EX-527; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxami

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2014 سفارش ترجمه

The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease

Keywords: پپتید آمیلیید ب; Alzheimer's disease; Amyloid-β peptide; γ-secretase inhibitor; Amyloid protein seeding; Drug discovery;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: Implications for low vitamin D-dependent age-related cognitive decline

Keywords: پپتید آمیلیید ب; 3-NT; 3-nitrotyrosine; BCIP; 5-bromo-4-chloro-3-indolyl-phosphate; 6-PFK; 6-phosphofructokinase; ALP; alkaline phosphatase activity buffer; Aβ; amyloid-β peptide; BSA; bovine serum albumin; VitD3; cholecalciferol; 25-OH VitD; calcidiol, 25-hydroxyvitami

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportApigenin attenuates copper-mediated β-amyloid neurotoxicity through antioxidation, mitochondrion protection and MAPK signal inactivation in an AD cell model

Keywords: پپتید آمیلیید ب; Alzheimer's disease; Amyloid-β peptide; Apigenin; Apoptosis; Mitochondrion;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

The genus Cynomorium in China: An ethnopharmacological and phytochemical review

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; ConA; concanavalin; CSP; C. songaricum polysaccharides; DA; dopamine; DAT; dopamine transporter; DPPH; 2,2-diphenyl-1-picrylhydrazyl; FSH; follicle-stimul

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Total saponins from Rhizoma Anemarrhenae ameliorate diabetes-associated cognitive decline in rats: Involvement of amyloid-beta decrease in brain

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; CHCl3; chloroform; DACD; diabetes-associated cognitive decline; DM; diabetes mellitus; EtOH; ethyl alcohol; FBG; fasting blood glucose; HCl; hydrogen chloride; H2SO4; sulphuric acid; IL; interleukin; MeOH; methyl alcohol; NF-κB;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

BACE1 in Alzheimer's disease

Keywords: پپتید آمیلیید ب; Aβ; β-amyloid; ACDL; acid-cluster dileucine motif; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease domain protein; AICD; amyloid precursor protein intracellular domain; APLP; amyloid precursor-like protein; ApoE; apolipoprotein E; APP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease

Keywords: پپتید آمیلیید ب; 2N; normal disomic littermates; AD; Alzheimer's disease; Aβ; amyloid-β peptide; APP; amyloid-β precursor protein; ANOVA; analysis of variance; ApoE; apolipoprotein E; CH; calcium and potassium channels; CBF; cholinergic basal forebrain; Ct; cycle thres

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells

Keywords: پپتید آمیلیید ب; ROBKOHOXCCIGKA-YDHLFZDLSA-N; CTIXSYGGXMDSBQ-UHFFFAOYSA-N; RXRSCJCBYDKOQS-LTDRVIOCSA-N; MVXLOAFTFDPCPK-LTDRVIOCSA-N; GTGDGIDWSMIASH-UHFFFAOYSA-N; LQLIXLQXXVQGEH-AAAIIBCSSA-N; UFXCYDLBJWLCQS-LTDRVIOCSA-N; JXTAMIXHZPMMRQ-UHFFFAOYSA-N; MFXXCQOJSTXKBJ-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

Keywords: پپتید آمیلیید ب; acyl-SG; S-acyl glutathione; AD; Alzheimer disease; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BODIPY; 4,4-difluoro-3a,4a-diaza-s-indacene; ChAT; choline acetyltransferase; CM-H2DCFDA; 2′,7′-dichlorodihydrofluorescein diacetate, acetyl e

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

Keywords: پپتید آمیلیید ب; Preclinical Alzheimer's disease; Aβ-oligomers; Inflammation; iNOS; COX-2; AD; Alzheimer's disease; MCI; mild cognitive impairment; Aβ; amyloid-β peptide; Tg; transgenic; APP; amyloid precursor protein; ADDLs; Alzheimer's disease diffusible ligands; M

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer's Aβ peptide

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; ATR-FT-IR; attenuated total reflectance Fourier-transform infrared; DMSO; dimethyl sulfoxide; FHSQC; fast heteronuclear single quantum coherence; HEPES; 4-(2-hydroxyethyl)-1-piperazineethane-sulfonic acid; His; histidine; ThT; thi

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

A partially folded structure of amyloid-beta(1-40) in an aqueous environment

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; DSS; 4,4-dimethyl-4-silapentane-1-sulfonic acid; NOE; nuclear overhauser effect; MD; molecular dynamics; TOCSY; total correlation spectroscopy; NOESY; nuclear overhauser effect spectroscopy; NMR; nuclear magnetic resonance; Struct

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Research ReportAtorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; AD; Alzheimer's disease; AGEs; advanced glycation end products; APP; amyloid precursor protein; BBB; blood-brain barrier; HE; hematoxylin-eosin; HMG-CoA; 3-hydroxy-3-methyl glutaryl coenzyme A; 4-HNE; 4-hydroxy-2-nonenal; Iba-1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells

Keywords: پپتید آمیلیید ب; α-CTF; α-cleaved carboxyterminal fragment of APP (also known as C83); Aβ; amyloid-β peptide; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BACE; β-secretase; BBG; brilliant blue G; BzATP; 2′(3â€

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Resolution of localized small molecule-Aβ interactions by deep-ultraviolet resonance Raman spectroscopy

Keywords: پپتید آمیلیید ب; Alzheimer's disease; Amyloid-β peptide; Ultraviolet resonance Raman; Circular dichroism; Thioflavin T; Myricetin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of fatty acid unsaturation numbers on membrane fluidity and α-secretase-dependent amyloid precursor protein processing

Keywords: پپتید آمیلیید ب; AA; arachidonic acid; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; ALA; α-linolenic acid; APP; amyloid precursor protein; Aβ; amyloid-β peptide; BCA; bicinchoninic acid; BSA; bovine serum albumin; DHA; docosahexaenoic acid; DMEM; D

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Research ReportAtorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; 8-ARM; radial 8 arm maze; BrW; brain weight; BW; body weight; CNS; central nervous system; HDL-C; high-density lipoprotein cholesterol; HMG-CoA; 3-hydroxy-3-methyl glutaryl

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Keywords: پپتید آمیلیید ب; Alzheimer's disease; Amyloid-β peptide; Aβ; Oligomers; Cognition;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Role of Aβ-receptor for advanced glycation endproducts interaction in oxidative stress and cytosolic phospholipase A2 activation in astrocytes and cerebral endothelial cells

Keywords: پپتید آمیلیید ب; Aβ42; RAGE; NADPH oxidase; ERK; cPLA2; AbRAGE; anti-RAGE antibody; AD; Alzheimer's disease; Aβ; amyloid-β peptide; Aβ42; amyloid-β oligomers; BBB; blood-brain barrier, CEC, cerebral endothelial cell; cPLA2; cytosolic phospholipase A2; ERK; extracel

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Modeling neurodegenerative disease pathophysiology in thiamine deficiency: Consequences of impaired oxidative metabolism

Keywords: پپتید آمیلیید ب; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AQP-4; aquaporin-4; ATP; adenosine triphosphate; Aβ; amyloid-β peptide; APP; amyloid precursor protein; BBB; blood-brain barrier; BCSFB; blood-cerebrospinal fluid barrier; CT; computed tom

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

HSV-1 promotes Ca2+-mediated APP phosphorylation and Aβ accumulation in rat cortical neurons

Keywords: پپتید آمیلیید ب; Intracellular Ca2+ signals; Cav1 channels; Herpes simplex virus type 1; Amyloid-β peptide; Persistent Na+ currents; Amyloid precursor protein; APP phosphorylation; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity

Keywords: پپتید آمیلیید ب; AD; Alzheimer's diseases; APP; amyloid precursor protein; Aβ; amyloid-β peptide; ACSF; artificial cerebral spinal fluid; BCA; bicinchoninic acid; CF; 5-carboxyfluorescein; DBU; 1,8-diazabicyclo[5,4,0]-undec-7-ene; DCF; dichlorofluorescein diacetate; DIV

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Lipid peroxidation and neurodegenerative disease

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; ALDO1; aldolase; AD; Alzheimer disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; CK; creatine kinase; CR1; carbonyl reductase; CSF; cerebrospinal fluid; DHA; doco

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

The organellar peptidasome, PreP: A journey from Arabidopsis to Alzheimer's disease

Keywords: پپتید آمیلیید ب; Mitochondria; Presequence protease; Peptide degradation; Amyloid-β peptide; Alzheimer's disease; Targeting peptide;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Density functional theory analysis and spectral studies on amyloid peptide Aβ(28-35) and its mutants A30G and A30I

Keywords: پپتید آمیلیید ب; Alzheimer's disease; Amyloid-β peptide; Mutant peptide; Conformational analysis; B3LYP/6-31G∗ structural optimization; Aβ; amyloid-β peptide; AD; Alzheimer's disease; CD; circular dichroism; DFT; density functional theory; FRET; fluorescence reso

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis of fluorescent-maghemite nanoparticles as multimodal imaging agents for amyloid-β fibrils detection and removal by a magnetic field

Keywords: پپتید آمیلیید ب; Magnetic iron oxide nanoparticles; Fluorescent probe; Protein folding; Amyloid-β peptide; Neurodegenerative diseases;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Human apolipoprotein A-I binds amyloid-β and prevents Aβ-induced neurotoxicity

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; AD; Alzheimer's disease; apoA-I; apolipoprotein A-I; BHT; butylated hydroxytoluene; calcein AM; calcein acetoxymethylester; CSF; cerebrospinal fluid; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide; PBS; phosp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

N-truncated amyloid-β oligomers induce learning impairment and neuronal apoptosis

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; AD; Alzheimer's disease; cPLA2; cytosolic calcium-dependent phospholipase A2; DAPI; 4,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle's medium; icv; intracerebroventricular; MAFP; methyl arachidonyl fluorophosphonate;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2008 سفارش ترجمه

Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; APPNL-H4 cells; H4 cells stably expressing Swedish-type of human APP695; ELISA; enzyme-linked immunosorbent assay; FL; full-length; LDH; lactate dehydrogenase; LDL; low-de

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-β peptide

Keywords: پپتید آمیلیید ب; HNE; 4-hydroxy-2-nonenal; A β; amyloid-β peptide; PLPC; 1-palmitoyl-2-linoleoyl phosphatidylcholine; PLPC-OOH; 1-palmitoyl-2-(13-hydroperoxy-cis-9, trans-11-octadecadienoyl) phosphatidylcholine; GHL; glycyl-l-histidyl-l-lysine; CL-HPLC; chemiluminesce

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Novel isoforms of NADPH-oxidase in cerebral vascular control

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; ACE; angiotensin-converting enzyme; ACh; acetylcholine; AD; Alzheimer's disease; AEBSF; aminoethylbenzenesulfono fluoride; APP; amyloid precursor protein; CBF; cerebral blood flow; cGMP; guanosine monophosphate; DETCA; diethyldith

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2006 سفارش ترجمه

Contribution of simple saccharides to the stabilization of amyloid structure

Keywords: پپتید آمیلیید ب; Amyloid-β peptide; Cosolvent; Monosaccharide; Circular dichroism; Electron microscopy; Osmolyte; Molecular crowding;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Metales de transición y enfermedad de Alzheimer

Keywords: پپتید آمیلیید ب; Enfermedad de Alzheimer; Placas seniles; Péptido β-amiloide; Metales de transición; Alzheimer's disease; Senile plaques; Amyloid-β peptide; Transition metals;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Antisense inhibition of acetylcholinesterase gene expression for treating cognition deficit in Alzheimer's disease model mice

Keywords: پپتید آمیلیید ب; Sensory system; Pain modulation: pharmacology; Antisense oligodeoxynucleotide; Acetylcholinesterase; Alzheimer's disease; Amyloid-β peptide;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Amyloid-β fibril formation is not necessarily required for microglial activation by the peptides

Keywords: پپتید آمیلیید ب; Alzheimer's disease; Microglia; Amyloid-β peptide; Peptide aggregation; Circular dichroism spectroscopy; Thioflavine-T fluorometric assay;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Presenilin endoproteolysis is an intramolecular cleavage

Keywords: پپتید آمیلیید ب; Aβ; amyloid-β peptide; APP; β-amyloid precursor protein; CTF; C-terminal fragment; ELISA; enzyme-linked immunosorbent assay; FL; full-length; HEK; human embryonic kdney 293; IP; immunoprecipitation; MEF; mouse embryonic fibroblasts; NΔE; Notch ΔE; NC

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه