
The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation
Keywords: دیمتیل سولفواکسید; hTop1B; human topoisomerase 1B; CPT; camptothecin; TPT; topotecan; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; DTT; dithiothreitol; BSA; bovine serine albumin; TBE; tris-borate-EDTA; PMSF; pheny