دانلود مقالات ISI درباره بیماری پارکینسون + ترجمه فارسی

Design, synthesis and biological evaluation of peptide derivatives of l-dopa as anti-parkinsonian agents

Keywords: بیماری پارکینسون; l-Dopa; Prodrug; Parkinson's disease; 6-Hydroxydopamine (6-OHDA) lesioned rat;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Novel cinnoline-based inhibitors of LRRK2 kinase activity

Keywords: بیماری پارکینسون; LRRK2; Leucine rich repeat kinase 2; Parkinson's disease; Kinase inhibitors;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Manganese efflux in Parkinsonism: Insights from newly characterized SLC30A10 mutations

Keywords: بیماری پارکینسون; Manganese; SLC30A10; Ferroportin 1; Parkinson's disease; Iron;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease

Keywords: بیماری پارکینسون; Vesicular monoamine transporter 2; SNP; Association; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The BAG2 protein stabilises PINK1 by decreasing its ubiquitination

Keywords: بیماری پارکینسون; PD; Parkinson disease; PINK1; mutations in PTEN-induced kinase 1; UPS; ubiquitin proteasome system; BAG; Bcl-2associated athanogene; BAG2; Bcl-2-associated athanogene 2; DMEM; Dulbecco's modified Eagle's medium; BAG2; PINK1; Parkinson's disease; Ubi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Heptachlor induced mitochondria-mediated cell death via impairing electron transport chain complex III

Keywords: بیماری پارکینسون; Heptachlor; Parkinson's disease; Mitochondria; Pesticide; Apoptosis; Reactive oxygen species;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration

Keywords: بیماری پارکینسون; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; CP-31398; N′-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine dihydrochloride; CNS; central nervous system; DAPI; 4′,6′-diamidino-2-phenylindole; DIV; days

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2

Keywords: بیماری پارکینسون; Leucine-rich repeat kinase 2; LRRK2; LRRK2 inhibitors; Kinase inhibitors; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Protective effect of orexin-A on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells

Keywords: بیماری پارکینسون; Orexin-A; Parkinson's disease; 6-Hydroxydopamine; Apoptosis; SH-SY5Y cells;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Geraniol attenuates α-synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner

Keywords: بیماری پارکینسون; Parkinson's disease; Degeneration; MPTP; Geraniol; Neuroprotective;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors

Keywords: بیماری پارکینسون; Polo like kinase; PLK inhibitor; Parkinson's disease; Alpha-synuclein;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The development of CNS-active LRRK2 inhibitors using property-directed optimisation

Keywords: بیماری پارکینسون; PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; DLP1; dynamin-like protein 1; FOXO1; forkhead box transcription factor; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; SBDD; structure-based drug design; HTS; high throughput

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation of haloperidol-induced catalepsy in rats by GABAergic neural substrate in the inferior colliculus

Keywords: بیماری پارکینسون; IC; inferior colliculus; MDZ; midazolam; MK-801; (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine maleate; NMDA; N-methyl-d-aspartate; PD; Parkinson's disease; SNpr; substantia nigra pars reticulata; haloperidol; catalepsy; GABA; midazo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

GC-MS analysis of Eucalyptus citriodora leaf extract and its role on the dietary supplementation in transgenic Drosophila model of Parkinson's disease

Keywords: بیماری پارکینسون; Eucalyptus citriodora; Parkinson's disease; Climbing ability; Oxidative stress; Drosophila melanogaster;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Combination of group I mGlu receptors antagonist with dopaminergic agonists strengthens the synaptic transmission at corticostriatal synapses in culture

Keywords: بیماری پارکینسون; Metabotropic glutamate receptor; Dopamine receptor; Corticostriatal synapse; Primary cell culture; Synaptic plasticity; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Redox modification of proteins as essential mediators of CNS autophagy and mitophagy

Keywords: بیماری پارکینسون; Mitophagy; Reactive oxygen species; Energetics; FOXO; HIF; Sirtuin; Atg; p66shc; Neurodegeneration; Amyotrophic lateral sclerosis; Isocitrate dehydrogenase; Mitochondria; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of function

Keywords: بیماری پارکینسون; TDP-43; trans-activation region DNA-binding protein of 43-kDa; RRM; RNA recognition motif; ALS; amyotrophic lateral sclerosis; FTLD; frontotemporal lobar degeneration; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; NTD;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The secreted oligomeric form of α-synuclein affects multiple steps of membrane trafficking

Keywords: بیماری پارکینسون; α-Synuclein; Parkinson's disease; Transferrin receptor; Membrane trafficking; Endocytosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease

Keywords: بیماری پارکینسون; Monoamine oxidase B; MAO-B; Parkinson's disease; Oxazolopyridine; Thiazolopyridine;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

AIF, reactive oxygen species, and neurodegeneration: A “complex” problem

Keywords: بیماری پارکینسون; AIF; apoptosis inducing factor; DCFH-DA; dichlorodihydrofluorescein; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NMDA; N-methyl d-aspartate; ROS; reactive oxygen species; Mitochondria; Electron transport; Complex

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

In vivo administration of VEGF- and GDNF-releasing biodegradable polymeric microspheres in a severe lesion model of Parkinson's disease

Keywords: بیماری پارکینسون; Parkinson's disease; Microparticles; GDNF; VEGF; PLGA; 6-OHDA; Growth factors;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Isolation, characterization, and neuroprotective activities of sesquiterpenes from Petasites japonicus

Keywords: بیماری پارکینسون; Petasites japonicus; Sesquiterpenes; Neuroprotective activities; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Evidence of oxidative stress in young and aged DJ-1-deficient mice

Keywords: بیماری پارکینسون; Parkinson's disease; DJ-1; Oxidative stress; Heat shock protein; Aging; Nigrostriatal; Chaperone;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics

Keywords: بیماری پارکینسون; 1,4-Dihydropyrimidines; 4H-Pyrans; CaV1.3 Ca2+ channel; CaV1.2 Ca2+ channel; L-type calcium channel; Parkinson's disease; FLIPR (Fluorometric imaging plate reader); Antagonism;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein

Keywords: بیماری پارکینسون; Parkinson's disease; α-Synuclein; Vitamin K; Naphthoquinones; Fibrils;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Neuroprotective mechanisms of the standardized extract of Bacopa monniera in a paraquat/diquat-mediated acute toxicity

Keywords: بیماری پارکینسون; Parkinson's disease; Neuroprotection; Oxidative stress; Bacopa monniera; Redox regulation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Exploring the accessible conformations of N-terminal acetylated α-synuclein

Keywords: بیماری پارکینسون; αsyn; α-synuclein; Ac-αsyn; acetylated α-synuclein; BOG; beta-octyl glucopyranoside; GST; glutathione S-transferase; CD; circular dichroism; CN-PAGE; clear native PAGE; ESI-MS; electrospray ionization-mass spectrometry; ESI-IMS-MS; electrospray ioni

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Isradipine prevents rotenone-induced intracellular calcium rise that accelerates senescence in human neuroblastoma SH-SY5Y cells

Keywords: بیماری پارکینسون; [Ca2+]i; intracellular Ca2+ concentrations; CDK2; Cyclin-dependent kinase 2; DHP; dihydropyridine; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethylsulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetra-acetic acid; ELISA; en

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Gene expression profiling of rotenone-mediated cortical neuronal death: Evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signaling

Keywords: بیماری پارکینسون; GSH; glutathione; OXPHOS; oxidative phosphorylation; PD; Parkinson's disease; PCD; programmed cell death; ROS; reactive oxygen species; UPS; ubiquitin-proteasome system; Rotenone; Oxidative stress; Mitochondria complex I inhibition; Programmed cell de

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains

Keywords: بیماری پارکینسون; aSyn; α-synuclein; ANOVA; analysis of variance; DOPAC; 3,4-dihydroxyphenylacetic acid; DA; dopamine; HVA; homovanillic acid; 5-HT; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; LB; Lewy bodies; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PFA; p

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: Glutamate N2A/B/D [GluRε1/2/4] subtypes and the GABA synthesizing enzyme GAD65

Keywords: بیماری پارکینسون; ANCOVA; analysis of covariance; DA; dopamine; GAD65; glutamate decarboxylase; HD; Huntington's disease; HET; heterozygous; KO; knockout; PD; Parkinson's disease; S.E.M.; standard error of the mean; SKF 83959; [R/S]-3-methyl-6-chloro-7,8-dihydroxy-1-[3

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Three-month subchronic intramuscular toxicity study of rotigotine-loaded microspheres in SD rats

Keywords: بیماری پارکینسون; Rotigotine-loaded microspheres; Subchronic toxicity; Sustained-release; Continuous dopaminergic stimulation; Dopamine agonist; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

bFGF promotes the differentiation and effectiveness of human bone marrow mesenchymal stem cells in a rotenone model for Parkinson's disease

Keywords: بیماری پارکینسون; PD; Parkinson's disease; TJMC & HUST; Tongji Medical College, Huazhong University of Science and Technology; BMSCs; bone marrow mesenchymal stem cells; HBMSCs; human BMSCs; bFGF; basic fibroblast growth factor; TEM; transmission electron microscope; SNc

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats

Keywords: بیماری پارکینسون; ·OH; hydroxyl radical; 6-OHDA; 6-hydroxydopamine; BN-PAGE; blue native-polyacrylamide gel electrophoresis; DA; dopamine; DHBA; dihydroxybenzoic acid; EDTA; ethylenediamine tetraacetic acid; ETC; electron transport chain; GSH; reduced glutathione; GSSG; o

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Keywords: بیماری پارکینسون; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethyl sulfoxide; DPBS; Dulbecco's phosphate-buffered saline; EDTA; ethylenediaminetetraacetic acid; FCS; foetal calf serum; GFAP; glial fibrillary acid protein; IL; interleukin; LDH; lactate dehydrogena

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

ATP-ases of synaptic plasma membranes in striatum: Enzymatic systems for synapses functionality by in vivo administration of l-acetylcarnitine in relation to Parkinson's Disease

Keywords: بیماری پارکینسون; AChE; acetylcholinesterase; AD; Alzheimer's Disease; ANOVA; analysis of variance; AP; action potentials; DTNB; 5,5′-dithiobis-(2-nitrobenzoic acid); EDTA; ethylenediamine tetraacetic acid; EGTA; ethylene glycol tetraacetic acid; HEPES; 4-(2-hydroxyeth

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model

Keywords: بیماری پارکینسون; AD; Alzheimer's disease; ADYLC3; adenylyl cyclase 3; ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CJD; Creutzfeldt-Jakob disease; CNG; cyclic nucleotide-gated; Gnal; olfactory G protein; GUS-β; β-glucuronidase; HSD; Honestly Si

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner

Keywords: بیماری پارکینسون; ANOVA; analysis of variance; HO-1; heme oxygenase 1; HSF1; heat shock factor 1; Hsc70; heat shock cognate 70; Hsp70; heat shock protein 70; PBS; phosphate-buffered saline; Parkinson's disease; Alzheimer's disease; heat shock protein 70; heat shock cog

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Original ResearchAntiparkinson Drug Use and Adherence in Medicare Part D Beneficiaries With Parkinson's Disease

Keywords: بیماری پارکینسون; antiparkinson drug; Medicare; medication adherence; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA

Keywords: بیماری پارکینسون; 6-OHDA animal model of Parkinson's disease; Dopamine and serotonin metabolism; L-DOPA; Molsidomine; Nitric oxide; Rotational behavior; ANOVA; analysis of variance; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; HPLC; high-pressure liquid chromatog

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Attenuation of MPTP/MPP+ toxicity in vivo and in vitro by an 18-mer peptide derived from prosaposin

Keywords: بیماری پارکینسون; ALT; alanine transaminase; anti-GFAP; anti-glial fibrillary acidic protein; AST; aspartate transaminase; BSA; bovine serum albumin; BUN; blood urea nitrogen; Cr; creatinine; DA; dopamine; DAPI; 4′-6-diamidino-2-phenylindole; DAT; dopamine transporter; D

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment

Keywords: بیماری پارکینسون; REM sleep behavior disorder; Electroencephalography; Spectral analysis; Mild cognitive impairment; Parkinson's disease; Dementia with Lewy bodies;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2013 سفارش ترجمه

Dominant-negative effects of LRRK2 heterodimers: A possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation

Keywords: بیماری پارکینسون; Parkinson's disease; LRRK2; Heterodimer; Dominant-negative effect; Akt1 phosphorylation; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2013 سفارش ترجمه

1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

Keywords: بیماری پارکینسون; Alzheimer's disease; Anellated xanthines; Tetrahydropyrimido[2,1-f]purinediones; Adenosine A1 receptor antagonists; Adenosine A2A receptor antagonists; Caffeine derivatives; Monoamine oxidase B inhibitors; Parkinson's disease; Tricyclic compounds; Syn

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2013 سفارش ترجمه

Detecting and testing altered brain connectivity networks with k-partite network topology

Keywords: بیماری پارکینسون; Brain network statistics; Connectivity; k-partite graph; Network topological statistics; Parkinson's disease;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2020 سفارش ترجمه

Treatment with the noradrenaline re-uptake inhibitor atomoxetine alone and in combination with the α2-adrenoceptor antagonist idazoxan attenuates loss of dopamine and associated motor deficits in the LPS inflammatory rat model of Parkinson's disease

Keywords: بیماری پارکینسون; Parkinson's disease; Noradrenaline; Atomoxetine; LPS; Rat;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of Resistance Training for People With Parkinson's Disease: A Systematic Review

Keywords: بیماری پارکینسون; Parkinson's disease; strength training; resistance training; weight lifting; exercise therapy; progressive resistance training; muscle strength;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The adenosine A2A antagonistic properties of selected C8-substituted xanthines

Keywords: بیماری پارکینسون; Adenosine A2A receptors; Antagonism; Xanthine; Haloperidol-induced catalepsy; Parkinson's disease; CNS; central nervous system; CPA; cyclopentyladenosine; CSC; (E)-8-(3-chlorostyryl)caffeine; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; EDAC; N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha

Keywords: بیماری پارکینسون; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; adenosine monophosphate-activated protein kinase; Aβ; beta-amyloid; DHE; dihydroethidium; hNSCs; human neural stem cells; NRF1; nuclear respiratory factor1; PCR; polymerase chain reacti

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Rotenone-induced neurotoxicity in rat brain areas: A study on neuronal and neuronal supportive cells

Keywords: بیماری پارکینسون; ANOVA; one way analysis of variance; BSA; bovine serum albumin; DMSO; dimethyl sulphoxide; EDTA; ethylenediamine tetraacetic acid; GFAP-ir; glial fibrillary acidic protein immunoreactivity; IF; immunofluorescence; ir; immunoreactivity; MB; mid brain; LPS;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه