دانلود مقالات ISI درباره Serm + ترجمه فارسی

Not lost in translation: Emerging clinical importance of the G protein-coupled estrogen receptor GPER

Keywords: ER; estrogen receptor; GPER; G protein-coupled estrogen receptor; GPR30; G protein-coupled receptor 30; SERD; selective estrogen receptor downregulator; SERM; selective estrogen receptor modulator; DDT; dichlorodiphenyltrichloroethane; Autoimmune disease;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Oxysterols: From cholesterol metabolites to key mediators

Keywords: ABC; ATP-binding cassette; ACAT; acyl-coenzyme A cholesterol acyltransferase; C4; 7-hydroxycholestenone; CA; cholestanoic acid; CH25H; cholesterol-25-hydroxylase; ChEH; cholesterol epoxide hydrolase; CNS; central nervous system; CSF; cerebrospinal fluid;

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and biological evaluation of novel m-carborane-containing estrogen receptor partial agonists as SERM candidates

Keywords: Carborane; Estrogen receptor; Partial agonist; SERM;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

The effects of bazedoxifene on bone structural strength evaluated by hip structure analysis

Keywords: BMD; bone mineral density; BR; buckling ratio; BZA; bazedoxifene; CSA; cross-sectional area; DXA; dual-energy X-ray absorptiometry; HAS; hip structure analysis; OD; outer diameter; SERM; selective estrogen receptor modulator; SM; section modulus; Bazedoxi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The investigation of miR-221-3p and PAK1 gene expressions in breast cancer cell lines

Keywords: qRT-PCR; Real-time PCR; ER/PR; estrogen and progesterone receptor; HER2; human epidermal growth factor receptor 2; SERM; selective ER modulators; SRC-1; steroid receptor coactivator-1; miRNA; microRNAs; DMEM; Dulbecco's modified Eagle's minimum essential

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Selective estrogen receptor modulators (SERMs): A review of clinical data

Keywords: SERM; Menopause; Breast cancer; Osteoporosis; Endometrial cancer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity

Keywords: VDR; vitamin D receptor; LBD; ligand-binding domain; 1α,25-(OH)2D3; 1α,25-dihydroxyvitamin D3; SERM; selective estrogen receptor modulator; ERα; estrogen receptor α; PPARγ; peroxisome proliferator-activated receptor γ; Vitamin D; Nuclear receptor; X

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines

Keywords: GBM; glioblastoma; MGMT; O6-methylguanine-DNA methyltransferase; TMX; tamoxifen; TMZ; temozolomide; PKC; protein kinase C; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; PGP; (P-glycoprotein ); SERM; non-steroidal selective estrogen r

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and bioevaluation of novel 6-(4-Hydroxypiperidino)naphthalen-2-ol-based potential Selective Estrogen Receptor Modulators for breast cancer

Keywords: Breast cancer; Anticancer; Cytotoxic; SERM; 1-(4-Dialkylaminoethoxy)phenylmethyl-6-(4-hydroxypiperidino)naphthalen-2-ols; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

9-Demethoxy-medicarpin promotes peak bone mass achievement and has bone conserving effect in ovariectomized mice: Positively regulates osteoblast functions and suppresses osteoclastogenesis

Keywords: DMM; 9-demethoxy-medicarpin; BMD; bone mineral density; MAR; mineral apposition rate; BFR; bone formation rate; NFkB; nuclear factor kappa B; OPG; osteoprotegrin; TRAP; tartarate resistant acid phosphatase; RANK; receptor activator of NFkB; SERM; selectiv

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Keywords: 17β-Hydroxysteroid dehydrogenase type 1; Interspecies differences; Estrogen-dependent diseases; Estrogen mimetics; Non-steroidal inhibitors; 17β-HSD1; 17β-hydroxysteroid dehydrogenase type 1; 17β-HSD2; 17β-hydroxysteroid dehydrogenase type 2; E1; est

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities

Keywords: Estrogen receptor; SERM; Antagonist; Estradiol

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Nuclear receptor modulation – Role of coregulators in selective estrogen receptor modulator (SERM) actions

Keywords: SERM; Nuclear receptor; Coregulator

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Human glutathione S-transferase P1-1 functions as an estrogen receptor α signaling modulator

Keywords: AF; activating function; AP; activating protein; ANOVA; analysis of variance; DMSO; dimethylsulfoxide; ERα; estrogen receptor α; ERE; estrogen response element; GSTP; human glutathione S-transferase P1-1; 4-OHT; 4-hydroxytamoxifen; IgG; immunoglobulin G

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene

Keywords: SERM; selective estrogen receptor modulator; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; GPCR; G protein-coupled receptor; FDA; food and drug administration; HTRF; homogenous time resolved fluorescence; Cannabinoid receptor; Inverse agonist;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

In vivo dynamics of estrogen receptor activity: The ERE-Luc model

Keywords: Reporter mouse; Estrogen receptor; SERM; Drug development; Phytoestrogens

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Immunomodulation by the estrogen metabolite 2-methoxyestradiol

Keywords: E2; 17β-Estradiol; 2me2; 2-Methoxyestradiol; COMT; Catechol-O-methyltransferase; ERs; Estrogen receptors; ERE; Estrogen response elements; ovx; Ovariectomized; orx; Orchidectomized; RA; Rheumatoid arthritis; SERM; Selective estrogen receptor modulators;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

Keywords: Selective estrogen receptor modulator; SERM; Tamoxifen; TSEC; Estrogen receptor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of coregulators influenced by estrogen receptor subtype specific binding of the ER antagonists 4-hydroxytamoxifen and fulvestrant

Keywords: 4OHT; 4-hydroxytamoxifen; ATP; adenosine triphosphate; BSA; bovine serum albumin; CCD; charge coupled device; CDTA; 1,2-diaminocyclohexanetetraacetic acid monohydrate; DCC-FCS; dextran-coated charcoal-treated fetal calf serum; DMEM; Dulbecco's modified

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells

Keywords: COUP-TFII; chicken ovalbumin upstream promoter transcription factor II; NFκB/NFkappa B; nuclear factor κB; SERM; selective estrogen receptor modulator; TAM; tamoxifen; ERα; estrogen receptor; SERD; selective estrogen receptor downregulator; 4-OHT; 4-hy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures

Keywords: Bent-core structure; Hydrophobic; Estrogen; Carborane; SERM;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

An overview of current and emerging SERMs

Keywords: CE; conjugated estrogens; CI; confidence interval; CTX; C-telopeptide; BMD; bone mineral density; DES; diethylstilbestrol; DMA; desmethylarzoxifene; ER; estrogen receptor; HR; hazard ratio; MORE; Multiple Outcomes of Raloxifene Evaluation; NTX; N-telopept

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen

Keywords: 4OH-Tam; 4OH-Tamoxifen; AC; adenylyl cyclase; CB1R; cannabinoid receptor type 1; CB2R; cannabinoid receptor type 2; CHO; Chinese hamster ovary; CP-55,940; 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]phenol; DMEM; Dulbecco's modific

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)

Keywords: ELISA; enzyme-linked immunosorbent assay; qRT-PCR; quantitative real-time reverse-transcription polymerase chain reaction; ER; estrogen receptor; SERM; selective estrogen receptor modulator; cAMP; cyclic adenosine monophosphate; ALP; alkaline phosphatase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis

Keywords: 27HC; 27-hydroxycholesterol; AR; Androgen receptor; ER; Estrogen receptor; LXR; Liver X receptor; RXR; Retinoid X receptor; SHP; Small heterodimeric partner; SERM; Selective estrogen receptor modulator; TSEC; Tissue selective estrogen receptor complexes;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on estrogen receptor (ER)-positive and ER-negative breast cancer cells

Keywords: CHOP; C/EBP homologous protein; E2; 17β-estradiol; ER; Estrogen receptor; ERα; Estrogen receptor α; ERβ; Estrogen receptor β; ERS; Endoplasmic reticulum stress; GRP75; A 75 kDa glucose regulated protein; IRE1α; Inositol-requiring protein 1 α; PERK;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells

Keywords: ER; estrogen receptor; PR; progesterone receptor; PR-A and PR-B; progesterone receptor isoform-A and B; AI; aromatase inhibitors; P450 CYP; cytochrome P450 family, hemprotein catalyze oxidation; CY19A1; aromatase gene; T47Dcon T47D; breast cancer cells st

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Expression and roles of steroidogenic acute regulatory (StAR) protein in 'non-classical', extra-adrenal and extra-gonadal cells and tissues

Keywords: OMM; outer mitochondrial membrane; IMM; inner mitochondrial membranes; TSPO; translocator protein; VDAC; voltage dependent anion channel; CNS; central nervous system; SR-BI; class-B type-I scavenger receptor; PTII; type II pneumonocytes; CCHCR1; Coiled-Co

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

The key involvement of estrogen receptor β and G-protein-coupled receptor 30 in the neuroprotective action of daidzein

Keywords: Ac-DEVD-pNA; N-acetyl-asp-glu-val-asp-p-nitro-anilide; DIV; day/days in vitro; DMSO; dimethyl sulfoxide; DPN; 2,3-bis(4-hydroxyphenyl)-propionitrile (highly potent ERβ agonist); EGTA; ethylene glycol tetraacetic acid; ELISA; enzyme-linked immunosorbent a

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Keywords: Biotransformation; Cytochrome P450 monooxygenase; NADPH:cytochrome P450 reductase; Pharmacogenetics; Polymorphism; Xenobiotic; ADME; absorption, distribution, metabolism, excretion; ADR; adverse drug reaction; AhR; aromatic hydrocarbon receptor; CNV; copy

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

Toremifene to Reduce Fracture Risk in Men Receiving Androgen Deprivation Therapy for Prostate Cancer

Keywords: osteoporosis; prostatic neoplasms; selective estrogen receptor modulators; toremifene; ADT; androgen deprivation therapy; AE; adverse event; BMD; bone mineral density; GnRH; gonadotropin-releasing hormone; HDL; high-density lipoprotein; LDL; low-density l

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Androgenic Action of Dehydroepiandrosterone (DHEA) on Nerve Density in the Ovariectomized Rat Vagina

Keywords: DHEA; Acolbifene; SERM; Nerve Density; Vagina; Intracrinology; Lamina Propria; Sexual Dysfunction; Postmenopause;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Long time exposure to soy/isoflavone-rich diet enhances testicular and prostate health in Long-Evans rats

Keywords: Testes; Prostate; Soy; Isoflavones; Diet; SERM

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors

Keywords: 3D-QSAR; Pharmacophore modeling; Virtual screening; Antiestrogenic activity; SERM; MCF-7

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Musculoskeletal ageing and primary prevention

Keywords: osteoporosis; sarcopenia; prevention; primary prevention; hormone replacement therapy; SARM; SERM

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Ovulation induction in women with polycystic ovary syndrome: an update

Keywords: clomiphene; insulin sensitizing agent; ovulation induction; SERM

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis

Keywords: SERM; Osteoporosis; Bazedoxifene; Lasofoxifene; Ospemifene; Arzoxifene

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleRaloxifene hydrochloride is an adjuvant antiviral treatment of postmenopausal women with chronic hepatitis C: A randomized trial

Keywords: HCV; hepatitis C virus; SVR; sustained virological response; SOC; standard of care; PegIFN; pegylated interferon; RBV; ribavirin; RLX; raloxifene hydrochloride; IL28B; interleukin-28B; SERM; selective estrogen receptor modulator; WBC; white blood cell; Hb

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Anti-oestrogenic diarylheptanoids from Aframomum melegueta with in silico oestrogen receptor alpha binding conformation similar to enterodiol and enterolactone

Keywords: Aframomum melegueta; Diarylheptanoids; ERα; Enterodiol; Enterolactone; Gingerenone; SERM;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening

Keywords: ER; SERM; Similarity search; Virtual screening; Anti-proliferative; AHQMKRDYCKXUFO-UHFFFAOYSA-N; VVYYBSJZWFZKCZ-UHFFFAOYSA-N; PVOSMOVHDHSYCE-UHFFFAOYSA-N; LEMLFUMEYPRRNF-UHFFFAOYSA-N; QEYPLJNCGQVHSF-UHFFFAOYSA-N; FQEGPIYLDRANCK-UHFFFAOYSA-N; TWYZJDASIMIAP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: Mechanisms and implications for immunity

Keywords: Estrogen; Estrogen receptor; Sex hormone; SERM; Immunoendocrinology; Dendritic cells; Antigen-presenting cells; Cellular differentiation; Inflammation; Hematopoiesis

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity

Keywords: Estrogen receptor beta; ER subtype selective agonists; Obesity; Genistein; Lipid metabolism; Skeletal muscle; αERKO; ER alpha knockout; Alpha; ER alpha specific agonist 16α-LE2; Beta; ER beta specific agonist 8β-VE2; BMI; body mass index; E2; 17β-estr

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Long-term resveratrol consumption protects ovariectomized rats chronically treated with d-galactose from developing memory decline without effects on the uterus

Keywords: Res; Resveratrol; AD; Alzheimer's disease; OVX; ovariectomized; d-ga; d-galactose; SERM; selective estrogen receptor modulator; ROS; reactive oxygen species; T-SOD; total superoxide dismutase; GSH-Px; glutathione peroxidase; TBARS; thiobarbituric acid rea

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Recent advances in the synthesis of raloxifene: A selective estrogen receptor modulator

Keywords: Raloxifene; Evista®; Estrogen Receptors; Heterocycles; Benzothiophenes; SERM; Steroids

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Sex hormone activity in alcohol addiction: Integrating organizational and activational effects

Keywords: AAS; anabolic-androgenic steroids; ACTH; adrenal corticotropin hormone; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; AMS; antenatal maternal stress; AR; androgen receptor; BMI; body mass index; CA1; Cornu Ammonis area 1; COMT; catechol-O-meth

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of Raloxifene on Endothelial Function and Hemostasis in Women With Ischemic Heart Disease

Keywords: FMD; Flow-mediated dilatation; PAI-1; Plasminogen activator inhibitor type-1; PAP; Plasmin/antiplasmin; SERM; Selective estrogen receptor modulator; TAFI; Thrombin-activatable fibrinolysis inhibitor; Endothelium; Coronary disease; Raloxifene; Fibrinolysis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents

Keywords: Anti-breast cancer; SERM; Anti-implantation; Raloxifene; Osteoporosis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Cellular mechanisms of acute decrease of glutamate release induced by raloxifene in rat cerebral cortex

Keywords: Raloxifene; Glutamate release; Synaptosomes; Voltage-dependent Ca2+ channels; ERK; Synapsin I; 4-AP; 4-aminopyridine; [Ca2+]C; cytosolic free Ca2+ concentration; DiSC3(5); 3′,3′,3′-dipropylthiadicarbocyanine iodide; DL-TBOA; DL-threo-beta-benzyl-oxy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Estrogenic environmental chemicals and drugs: Mechanisms for effects on the developing male urogenital system

Keywords: AR; androgen receptor; Ar; androgen receptor gene; Bmp4; bone morphogenetic protein 4; BPA; bisphenol A; Capn6; Calpain; Cyp7b1; cytochrome P450, family 7, subfamily b, polypeptide 1; DES; diethylstilbestrol; DHT; 5α-dihydrotestosterone; EGF; epidermal g

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Hormonal Modulation in the Treatment of Breast Cancer

Keywords: Hormonal modulation; Breast cancer; Aromatase inhibitors; Ovarian suppression; GnRH agonist; Antiestrogens; SERM; SERD;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه