TGF-β signaling plays an important role in resisting γ-irradiation
Keywords: TGF-β1; γ-irradiation; Smad; Apoptosis; DNA damage;
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Changes in the balance between Treg and Th17 cells in patients with chronic hepatitis B
Keywords: CHB; Chronic hepatitis B; HBV; Hepatitis B virus; PD-1; Procedural death factor-1; Treg; T; Th17; T helper 17; NK; Natural killer; DC; Dendritic cells; IL-17; Interleukin-17; TGF-β1; Transforming growth factor-β1; CHB-LM; Low to moderate chronic hepatit
Mesodermal and neural crest derived ovine tibial and mandibular osteoblasts display distinct molecular differences
Keywords: ALP; alkaline phosphatase; Runx2; Runt-related transcription factor 2; MSX1/2; homeobox protein MSX-1/2; TGF-β1; Transforming growth factor beta; BAMBI; Bmp and activin membrane-bound inhibitor; TWIST1; twist basic helix-loop-helix transcription factor 1
Original Full Length ArticleTransforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors
Keywords: TGF-β1; transforming growth factor beta 1; LIF; leukemia inhibitory factor; CED; Camurati-Englemann disease; QTL; quantitative trait locus; RANKL; receptor activator of NFκB ligand; M-CSF; macrophage colony stimulating factor; αMEM; alpha Minimal Ess
Arsenic trioxide induces cardiac fibroblast apoptosis in vitro and in vivo by up-regulating TGF-β1 expression
Keywords: ATO; arsenic trioxide; APL; acute promyelocytic leukemia; CFs; cardiac fibroblasts; NRCFs; neonatal rat cardiac fibroblasts; TGF-β1; transforming growth factor-β1; LY364947; TGF-β signaling inhibitor, its chemical formula is 4-[3-(2-pyridinyl)-1H-pyraz
Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis
Keywords: Resveratrol; Epithelial-to-mesenchymal transition (EMT); TGF-β1; Lung cancer; Invasion and metastasis;
Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats
Keywords: Cordyceps sinensis; Renal fibrosis; TGF-β1;
Original Full Length ArticleProlonged alendronate treatment prevents the decline in serum TGF-β1 levels and reduces cortical bone strength in long-term estrogen deficiency rat model
Keywords: Alendronate; TGF-β1; Cortical bone; Bone quality;
Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BSA; bovine serum albumin; CC; corpus callosum; CNS; central nervous system; EAAT; excitatory amino acid transporter; EAE; experimental allergic encephalomyelitis; ECL; enhanced chemiluminescenc
NF-κB p65 and c-Rel subunits promote phagocytosis and cytokine secretion by splenic macrophages in cirrhotic patients with hypersplenism
Keywords: Nuclear factor-kappa B (NF-κB); Phagocytosis; Cytokine secretion; Splenic macrophage; Hypersplenism; Liver cirrhosis; NF-κB; nuclear factor-kappa B; ChIP; chromatin immunoprecipitation; siRNA; small interfering RNA; IL-1α; interleukin-1α; IL-1β; inte
TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury
Keywords: Ligament healing; TGF-β1; Lysyl Oxidase; Matrix metalloproteinases;
Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
Keywords: α-SMA; α-smooth muscle actin; EMT; epithelial-to-mesenchymal transition; FSP-1; fibroblast-specific protein 1; HIF-1α; hypoxia-inducible factor 1α; PHD; prolyl hydroxylase domain; TFIID; transcription factor II D; TGF-β1; transforming growth factor b
Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells
Keywords: Apelin; ABCA1; PKCα; Calpain; Atherosclerosis; PKC; protein kinase C; ABCA1; ATP-binding cassette transporter A1; apoE; apolipoprotein E; RCT; reverse cholesterol transport; apoA-I; apolipoprotein A-I; TGF-β1; transforming growth factor-β1; IFN-γ; int
Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway
Keywords: AGE; Advanced glycation end product; AP-1; Activator protein 1; BUN; Blood urea nitrogen; Cr; Serum creatinine; Cur; Curcumin; DN; Diabetic nephropathy; ECM; Extracellular matrix; FBG; Fasting blood glucose; FN; Fibronectin; GBM; Glomerular basement membr
Research ArticlemiR-20a triggers metastasis of gallbladder carcinoma
Keywords: GBC; gallbladder carcinoma; TGF-β1; transforming growth factor-β1; Smad7; mothers against decapentaplegic homolog 7; EMT; epithelial-mesenchymal transition; Gallbladder carcinoma; microRNAs; EMT; Smad7; TGF-β1;
3,3â²-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction
Keywords: AhR; aryl hydrocarbon receptor; CCK-8; Cell Counting Kit-8; DAI; disease activity index; DIM; 3,3â²-diindolylmethane; DSS; dextran sodium sulfate; EAE; experimental autoimmune encephalomyelitis; ERα; estrogen receptor α; FICZ; 6-formylindolo[3,2-b]carb
Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation
Keywords: AEC; type II alveolar epithelial cells; CAPE; caffeic acid phenethyl ester; EMT; epithelial-mesenchymal transition; PPARγ; peroxisome proliferator-activated receptor gamma; RGZ; rosiglitazone; TGF-β1; transforming growth factor β1; Alveolar epithelia
Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells
Keywords: AGEs advanced; glycation end products; ROS; reactive oxygen species; GA; glycyrrhizic acid; HUVECs; human umbilical vein endothelial cells; AO/EB; acridine orange/ethidium bromide; BSA; non-glycated bovine serum albumin; AG; aminoguanidine; VE; Vitamin E;
HSP70 increases extracellular matrix production by human vascular smooth muscle through TGF-β1 up-regulation
Keywords: Fibrosis; Extracellular matrix; Smooth muscle; HSP70; TGF-β1;
The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts
Keywords: TGF-β1; transforming growth factor-β1; ECM; extracellular matrix; PI3K-Akt; phosphatidyl inositol 3 kinase-protein kinase B; MEK-Erk1/2; mitogen activated protein kinase 2-extracellular signal regulated kinase 1/2; Ras proteins; PI3K/Akt; MEK/ERK 1/2; T
Amelioration of compound 4,4â²-diphenylmethane-bis(methyl)carbamate on high mobility group box1-mediated inflammation and oxidant stress responses in human umbilical vein endothelial cells via RAGE/ERK1/2/NF-κB pathway
Keywords: AGEs; advanced glycation end products; HMGB1; high mobility group box1; CM1; 4,4â²-diphenylmethane-bis(methyl) carbamate; HUVECs; human umbilical vein endothelial cells; ICAM-1; intercellular adhesion molecule-1; TGF-β1; transforming growth factor-beta1
Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats
Keywords: Oxymatrine; Radix Sophorae flavescentis (Kushen); SHR; Ventricular remodeling; Gene overexpression; Signaling pathway; ACE; angiotensin converting enzyme; Ang II; angiotensin II; BSA; bovine serum albumin; BW; body weight; CHF; congestive heart failure; E
25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway
Keywords: 25-hydroxycholesterol; TGF-β1; Fibroblast; Tissue remodeling;
Differential vulnerability of adult neurogenesis by adult and prenatal inflammation: Role of TGF-β1
Keywords: Prenatal programming; Inflammation; Adult neurogenesis; Microglial activation; Neurogenic niche; TGF-β1;
The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia
Keywords: Tanshinone IIA; Cationic bovine serum albumin-conjugated PEGylated nanoparticles; Cerebral ischemia; Neuroprotection; MAPK signal pathways; TIIA; Tanshinone IIA; PEG; poly ethylene glycol; PLA; poly lactic acid; CBSA; cationic bovine serum albumin; MCAO;
Traditional uses, phytochemistry, pharmacology, pharmacokinetics and quality control of Polyporus umbellatus (Pers.) Fries: A review
Keywords: A. mellea; Armillariella mellea; AQP1; aquaporin-1; AQP2; aquaporin-2; AQP3; aquaporin-3; CaOx; calcium oxalate; CRF; chronic renal failure; CZE; capillary zone electrophoresis; Ergone; ergosta-4,6,8(14),22-tetren-3-one; FLD; fluorescence detection; FA-er
Surfactant phospholipid metabolism
Keywords: ABC; ATP-binding cassette transporter; ARDS; acute respiratory distress syndrome; CCT-CTP; phosphocholine cytidylyltransferase; CDP-choline; cytidine diphosphocholine; CDP-DAG; CDP-diacylglycerol; CDS-CDP; diacylglycerol synthase; CK; choline kinase; CL;
The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing
Keywords: Mesenchymal stem cells; Chemically defined carrier; Wound healing; TNF-α; TGF-β1; AT-MSCs; adipose tissue derived mesenchymal stem cells; ppAAc; plasma-polymerized acrylic acid; CFSE; carboxyfluorescein diacetate succinimidyl ester; CFU-F; colony formin
Mesothelial cell: A multifaceted model of aging
Keywords: Aging; Mesothelial cells; Oxidative stress; Peritoneum; Senescence; TGF-β1;
The T29C polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with genetic susceptibility to acute coronary syndrome in Mexican patients
Keywords: Acute coronary syndrome; Cytokine; Genetic susceptibility; Polymorphisms; TGF-β1;
The effects of Polygonum cuspidatum extract on wound healing in rats
Keywords: Polygonum cuspidatum extract; TGF-β1; Rat; Wound healing;
Human peroxiredoxin 1 modulates TGF-β1-induced epithelial-mesenchymal transition through its peroxidase activity
Keywords: hPrx1; TGF-β1; Epithelial-mesenchymal transition; E-cadherin; Peroxidase activity;
Fetal concentrations of the growth factors TGF-α and TGF-β1 in relation to normal and restricted fetal growth at term
Keywords: TGF-α; transforming growth factor-α; TGF-β1; transforming growth factor-β1; IUGR; intrauterine growth restriction; AGA; appropriate for gestational age; Fetus; Intrauterine growth restriction; TGF-α; TGF-β1; Umbilical cord blood;
miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells
Keywords: miR-134; Epithelial-to-mesenchymal transition (EMT); NSCLC; FOXM1; TGF-β1;
Candesartan antagonizes pressure overload-evoked cardiac remodeling through Smad7 gene-dependent MMP-9 suppression
Keywords: ARBs; Angiotensin II type 1 receptor blockers; TAC; transverse aortic constriction; AF; atrial fibrillation; EMT; Epithelial-to-mesenchymal transition; MMPs; matrix metalloproteinases; LVAWD and LVPWD; left ventricular anterior and posterior wall at end-d
Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder
Keywords: NGF; IGF-1; TGF-β1; Urinary bladder; Inflammation;
Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells
Keywords: EMT; epithelial-mesenchymal transition; LIGHT; homologous to lymphotoxins, exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes; TNFSF; tumor necrosis factor superfamily; TGF; transforming gr
Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-β/Smad signaling pathway
Keywords: ALI; acute lung injury; ARDS; acute respiratory distress symptom; LPS; lipopolysaccharide; MPO; myeloperoxidase; MDA; malondialdehyde; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; iNOS; inducible nitric oxide synthase; NO; nitric oxide; TGF-β1;
Measurement of human latent transforming growth factor-β1 using a latency associated protein-reactive ELISA
Keywords: FBS; fetal bovine serum; GFP; Green fluorescent protein; LAP; Latency associated protein; LTBP; Latent TGF-β binding protein; mAb; monoclonal antibody; PBMC; peripheral blood mononuclear cells; PBS; phosphate-buffered saline; rh; recombinant human; TGF-Î
Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3 infection and its potential role in cardiac fibrosis
Keywords: Coxsackievirus B3; Endothelial-to-mesenchymal transition; Cardiac fibrosis; TGF-β1; Cardiac microvascular endothelial cells;
Transforming Growth Factor-β1 Mediates Migration in Cultured Human Control and Exstrophy Bladder Smooth Muscle Cells
Keywords: urinary bladder; bladder exstrophy; muscle; smooth; translational medical research; Ach; acetylcholine; bSMC; bladder smooth muscle cell; [Ca2+]i; intracellular calcium concentration; CBE; classic bladder exstrophy; HBSS; HEPES buffered saline solution; H
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo
Keywords: HSC; hepatic stellate cell; NADPH oxidase (NOX); nicotinamide adenine dinucleotide phosphate reduced oxidas; BDL; bile duct ligation; TGF-β1; transforming growth factor-β; TNF-α; tumor necrosis factor α; αSMA; α-smooth muscle actin; ALT; alanine ami
Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy
Keywords: SE; Schisandra chinensis fruit extract; DN; diabetic nephropathy; EMT; epithelial-to-mesenchymal transition; PASM; periodic acid-silver methenamine; STZ; streptozotocin; ACR; albumin/creatinine ratio; UAE; urine albumin excretion; GSI; glomerulosclerotic
Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway
Keywords: Berberine; Mesangial cells; SphK1; AP-1; TGF-β1; FN;
Radiation-induced enteropathy: Molecular basis of pentoxifylline-vitamin E anti-fibrotic effect involved TGF-β1 cascade inhibition
Keywords: Radiation-induced fibrosis; Radiation enteropathy; Pentoxifylline; Tocopherol; TGF-β1; Rho/ROCK;
Research ArticleHAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis
Keywords: HSCs; hepatic stellate cells; HBV; hepatitis B virus; ECM; extracellular matrix; MMP; matrix metalloproteinase; TIMP; tissue inhibitor of metalloproteinase; TGF-β1; transforming growth factor-β1; HCC; hepatocellular carcinoma; EMT; epithelial-mesenchy
Preventive effects of rutin on the development of experimental diabetic nephropathy in rats
Keywords: Rutin; Diabetic nephropathy; CTGF; Smads; TGF-β1; Oxidative stress;
Topical application of Acalypha indica accelerates rat cutaneous wound healing by up-regulating the expression of Type I and III collagen
Keywords: Acalypha indica; Collagen; TGF-β1; TNF-α; Antioxidative;
Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma
Keywords: AHR; airway hyperresponsiveness; BAL; bronchoalveolar lavage; ELISA; enzyme-linked immunosorbent assay; TGF-β1; transforming growth factor-β1; OVA; ovalbumin; PAS; periodic acid-Schiff; SAL; saline; Skullcapflavone II; Asthma; Scutellaria baicalensis Ge
Loss of Akt1 evokes epithelial-mesenchymal transition by autocrine regulation of transforming growth factor-β1
Keywords: EMT; epithelial-mesenchymal transition; PI3K; phosphatidylinositol 3-kinase (EC = 2.7.1.153); TGF-β1; transforming growth factor-β1;