کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5511364 | 1539854 | 2017 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of iron in the pathogenesis of respiratory disease
ترجمه فارسی عنوان
نقش آهن در پاتوژنز بیماری های تنفسی
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کلمات کلیدی
TRALIferroportinDcytBduodenal cytochrome BPAPDMT1HIF-1αIFN-γARDSRBCLFRIPFNSCTransferrinTFRFPNRed blood cells - سلولهای قرمز خونtransfusion-related acute lung injury - آسیب ریوی حاد مرتبط با انتقال خونIron - آهنFBI - اف بی آیinterferon-γ - اینترفرون-γLung disease - بیماری ریهChronic obstructive pulmonary disease - بیماری مزمن انسدادی ریهCOPD - بیماری مزمن انسدادی ریهHost–pathogen interaction - تعامل میزبان-پاتوژنtumor necrosis factor-α - تومور نکروز عامل αNon-small-cell - سلول غیر سلولیAcute respiratory distress syndrome - سندرم دیسترس تنفسی حادhypoxia inducible factor-1α - عامل القایی هیپوکسی 1αInfection - عفونتTNF-α - فاکتور نکروز توموری آلفاidiopathic pulmonary fibrosis - فیبروز ریوی ایدیوپاتیکCystic fibrosis - فیبروز کیستیکLactoferrin - لاکتوفرینDivalent metal transporter 1 - متال فلچر 1Immunity - مصونیتtransferrin receptor - گیرنده انتقالینLactoferrin Receptor - گیرنده لاکتوفرین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Iron is essential for many biological processes, however, too much or too little iron can result in a wide variety of pathological consequences, depending on the organ system, tissue or cell type affected. In order to reduce pathogenesis, iron levels are tightly controlled in throughout the body by regulatory systems that control iron absorption, systemic transport and cellular uptake and storage. Altered iron levels and/or dysregulated homeostasis have been associated with several lung diseases, including chronic obstructive pulmonary disease, lung cancer, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. However, the mechanisms that underpin these associations and whether iron plays a key role in the pathogenesis of lung disease are yet to be fully elucidated. Furthermore, in order to survive and replicate, pathogenic micro-organisms have evolved strategies to source host iron, including freeing iron from cells and proteins that store and transport iron. To counter these microbial strategies, mammals have evolved immune-mediated defence mechanisms that reduce iron availability to pathogens. This interplay between iron, infection and immunity has important ramifications for the pathogenesis and management of human respiratory infections and diseases. An increased understanding of the role that iron plays in the pathogenesis of lung disease and respiratory infections may help inform novel therapeutic strategies. Here we review the clinical and experimental evidence that highlights the potential importance of iron in respiratory diseases and infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 88, July 2017, Pages 181-195
Journal: The International Journal of Biochemistry & Cell Biology - Volume 88, July 2017, Pages 181-195
نویسندگان
Md Khadem Ali, Richard Y. Kim, Rafia Karim, Jemma R. Mayall, Kristy L. Martin, Ali Shahandeh, Firouz Abbasian, Malcolm R. Starkey, Veronique Loustaud-Ratti, Daniel Johnstone, Elizabeth A. Milward, Philip M. Hansbro, Jay C. Horvat,