کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8713765 | 1587108 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Food allergy: AÂ review and update on epidemiology, pathogenesis, diagnosis, prevention, and management
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کلمات کلیدی
OFCCoFARFPIESLEAPEPITSLITTregSPTCRDNASFDANIAIDSpecific IgE - IgE اختصاصیFood allergens - آلرژن های غذاییFood allergy - آلرژی غذاییAnaphylaxis - آنافیلاکسی یا بیشدفاعی US Food and Drug Administration - اداره غذا و داروی ایالات متحدهepicutaneous immunotherapy - ایمونوتراپی epicutangeoral immunotherapy - ایمونوتراپی دهانSublingual immunotherapy - ایمونوتراپی زیر زبانیOral tolerance - تحمل خوراکیSkin prick test - تست خراش پوستیComponent-resolved diagnostics - تشخیص کامپوننت حل شدهFood hypersensitivity - حساسیت غذاییRelative risk - خطر نسبیAtopic dermatitis - درماتیت آتوپیکOIT - سازمان بین المللی کارDendritic cell - سلول دندریتیکFood protein–induced enterocolitis syndrome - سندرم Enterocolitis ناشی از پروتئین مواد غذاییRegulatory T - مقررات TNational Institute of Allergy and Infectious Diseases - موسسه ملی آلرژی و بیماری های عفونیodds ratio - نسبت شانس هاPrevention - پیشگیریOral food challenge - چالش خوراک خوراکیsIgE - گفتنLearning Early About Peanut - یادگیری اولیه در مورد بادام زمینی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This review provides general information to serve as a primer for those embarking on understanding food allergy and also details advances and updates in epidemiology, pathogenesis, diagnosis, and treatment that have occurred over the 4Â years since our last comprehensive review. Although firm prevalence data are lacking, there is a strong impression that food allergy has increased, and rates as high as approximately 10% have been documented. Genetic, epigenetic, and environmental risk factors are being elucidated increasingly, creating potential for improved prevention and treatment strategies targeted to those at risk. Insights on pathophysiology reveal a complex interplay of the epithelial barrier, mucosal and systemic immune response, route of exposure, and microbiome among other influences resulting in allergy or tolerance. The diagnosis of food allergy is largely reliant on medical history, tests for sensitization, and oral food challenges, but emerging use of component-resolved diagnostics is improving diagnostic accuracy. Additional novel diagnostics, such as basophil activation tests, determination of epitope binding, DNA methylation signatures, and bioinformatics approaches, will further change the landscape. AÂ number of prevention strategies are under investigation, but early introduction of peanut has been advised as a public health measure based on existing data. Management remains largely based on allergen avoidance, but a panoply of promising treatment strategies are in phase 2 and 3 studies, providing immense hope that better treatment will be imminently and widely available, whereas numerous additional promising treatments are in the preclinical and clinical pipeline.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 141, Issue 1, January 2018, Pages 41-58
Journal: Journal of Allergy and Clinical Immunology - Volume 141, Issue 1, January 2018, Pages 41-58
نویسندگان
Scott H. MD, Hugh A. MD,