کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9015942 | 1127601 | 2005 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of Rho GTPases and SNAREs in mediator release from granulocytes
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کلمات کلیدی
GTPRhoGDIGTPγSNADPHSNAREGTPaseVAMPNSFSNAP-25GEFMPO - DFOstreptolysin-O - streptolysin-oAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPEosinophils - ائوزینوفیلهاslo - اسلوRespiratory burst - انفجار تنفسیExocytosis - اگزوسیتوزGAP - شکافSNAP - ضربه محکم و ناگهانیN-ethylmaleimide-sensitive factor - عامل حساس N-ethylmaleimideguanine nucleotide exchange factor - فاکتور تبادل نوکلئوتید گوانینMast cells - ماست سل هاmyeloperoxidase - میلوپراکسیداز Neutrophils - نوتروفیل هاnicotinamide adenine dinucleotide phosphate - نیکوتین آمید adenine dinucleotide phosphateVesicle-associated membrane protein - پروتئین غشاء مرتبط با VesicleGTPase-activating protein - پروتئین فعال GTPaseGranules - گرانولGuanosine triphosphate - گوانوزین تری فسفاتguanosine triphosphatase - گوانوزین تری فسفاتازSNAP Receptor - گیرنده SNAP
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of Rho GTPases and SNAREs in mediator release from granulocytes The role of Rho GTPases and SNAREs in mediator release from granulocytes](/preview/png/9015942.png)
چکیده انگلیسی
Granulocytes are defined as the population of granulated white blood cells (eosinophils, neutrophils, and basophils). These cells are involved in inflammation and contribute to the pathogenesis of allergic and inflammatory diseases. Inflammation is induced by the release of mediators from granulocytes recruited to or resident within tissues, resulting in edema, leukocyte recruitment, and tissue injury. Eosinophils and neutrophils express Rac1 and Rac2 guanosine triphosphatases (GTPases), 2 members of the Rho GTPase subfamily of ras-related GTPases. Rho GTPases are activated by receptors in the cell membrane and are proposed to function as intracellular molecular switches to regulate mediator release, including exocytosis, from granulocytes. Exocytosis involves granule fusion, which requires the binding of intracellular membrane receptors known as SNAP receptor (SNAREs; soluble N-ethylmaleimide-sensitive factor [NSF] attachment protein [SNAP] receptors). Eosinophils and neutrophils express similar SNARE isoforms that are important in granule fusion events. Together, these molecules link together to form a common signaling pathway for mediator release from granulocytes. Identifying these molecules and their function may provide novel targets for the prevention of inflammatory reactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 107, Issue 3, September 2005, Pages 358-376
Journal: Pharmacology & Therapeutics - Volume 107, Issue 3, September 2005, Pages 358-376
نویسندگان
Paige Lacy,