Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus
Keywords: mGluR; TRPV1; Interneurons; Hippocampus; PLC; Intracellular calcium;
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Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex
Keywords: Ca2+; calcium; E cell; excitatory cell; E2/3 or E2; excitatory cell of layer 2/3, similarly E5, E6; E/I balance; excitation/inhibition balance; ER; endoplasmic reticulum; FRD; firing-rate distinction; FS cell; fast-spiking soma-targeting interneuron; HCN
Labile glutamate signaling onto CA1 pyramidal cells in the developing hippocampus depends mechanistically on input pathway
Keywords: ACSF; artificial cerebrospinal fluid; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; EPSP; excitatory postsynaptic potential; LTD; long-term depression; mGluR; metabotropic glutamate receptor; NMDA; N-methyl-d-aspartate; SC; Schaffer-collate
Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction
Keywords: BPnd; non-displacable binding potential; CG; cingulate cortex; CP; caudate putamen; CT; computed tomography; Ctrl; control; Ctrl-PBO; placebo-treated control cohort; Ctrl-NAc; NAc-treated control cohort; FOV; field of view; GSH; glutathion; HC; hippocampu
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
Keywords: AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ASD; autism spectrum disorder; BrdU; 5-bromo-2â²-deoxyuridine; CA; cornu ammonis; CaMKII; calcium/calmodulin-dependent protein kinase II; CGG; cytosine-guanine-guanine; DG; dentate gy
The afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery
Keywords: Cochlea; Inner hair cells; Type I spiral ganglion neurons; Lateral olivocochlear efferents; Ion channels and transporters; Neurotransmitter receptors; Postsynaptic density; Auditory neuropathy and synaptopathy; ABR; auditory brainstem response; ACh; acety
Involvement of P2X7 receptors in retinal ganglion cell apoptosis induced by activated Müller cells
Keywords: Glaucoma; Müller cell gliosis; Retinal ganglion cell; Apoptosis; P2X7 receptor; BBG; brilliant blue G; CM; conditioned culture medium; COH; chronic ocular hypertension; CNS; central nervous system; DAG; diacylglycerol; DHPG; (S)-3,5-Dihydroxyphenylglycin
Metabotropic glutamate receptors are involved in the detection of IMP and l-amino acids by mouse taste sensory cells
Keywords: AIDA; (RS)-1-aminoindan-1,5-dicarboxylic acid; Arg; l-arginine; CNQX; cyano-7-nitroquinoxaline-2,3-dione; CPPG; (RS)-α-cyclopropyl-4-phosphonophenylglycine; CTA; conditioned taste aversion; d-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DHPG; (S)-3,5-
Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex
Keywords: Medial prefrontal cortex; Pain; Synaptic transmission; mGluR; Patch-clamp;
mGluR5 protect astrocytes from ischemic damage in postnatal CNS white matter
Keywords: Astrocyte; mGluR; Glutamate; Ischemia; Calcium; White matter;
Glutamatergic regulation of brain histamine neurons: In vivo microdialysis and electrophysiology studies in the rat
Keywords: Histamine; Glutamatergic system; Circadian rhythm; Microdialysis; Electrophysiology; PH-TMN; posterior hypothalamus-tuberomamillary nucleus; mPFC; medial prefrontal cortex; vHipp; ventral hippocampus; NAc; nucleus accumbens; mGluR; metabotropic glutamate
Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1
Keywords: 5HT2AR; Serotonin 2A receptor; ACTH; Adrenocorticotropin hormone; ANOVA; Analysis of variance; CAL; CFTR-associated ligand; cAMP; Cyclic adenosine monophosphate; CFTR; Cystic Fibrosis Transmembrane Conductance Regulator; CNS; Central nervous system; CRF;
Research ReportMetabotropic glutamate receptor 5 upregulates surface NMDA receptor expression in striatal neurons via CaMKII
Keywords: mGluR; Striatum; GluN1; GluN2B; NR2B; G protein-coupled receptor; Phosphorylation; DHPG;
Activation of inositol 1,4,5-trisphosphate receptors during preconditioning low-frequency stimulation suppresses subsequent induction of long-term potentiation in hippocampal CA1 neurons
Keywords: 2-APB; 2-aminoethoxydiphenyl borate; 4-CPG; S-4-carboxyphenylglycine; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; AP5; d,l-2-amino-5-phosphonovalerate; A-PS; amplitude of the PS; CaMKII; calmodulin-dependent protein kinase II;
From development to disease: Diverse functions of NMDA-type glutamate receptors in the lower auditory pathway
Keywords: AMPA-R; α-amino-3-hydroxy-4-isoxazolepropionic acid-type glutamate receptor; DCN; dorsal cochlear nucleus; DNLL; dorsal nucleus of the lateral lemniscus; GABA; γ-aminobutyric acid; ICX; external nucleus of the inferior colliculus; IHC; inner hair cell;
New paradigms in GPCR drug discovery
Keywords: cAMP; 3â²,5â²-cyclic adenosine monophosphate; ADP; adenosine 5â²- diphosphate; GPCR; G protein-coupled receptor; TM; transmembrane helix; ERK; extracellular signal-regulated kinase; T4L; T-4 lysozyme; BRIL; thermostabilized apocytochrome b562; StaRs; s
Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors
Keywords: GPRC6A; CaSR; mGluR; Post-translational modifications; Glycosylation; Phosphorylation; Ubiquitination; Palmitoylation;
Regulation of hippocampal synaptic plasticity by BDNF
Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n
Research ReportFrom brain synapses to systems for learning and memory: Object recognition, spatial navigation, timed conditioning, and movement control
Keywords: Learning; Memory; Adaptive resonance theory; Attention; Category learning; Predictive remapping; Eye movement; Spatial navigation; Grid cell; Place cell; Time cell; Adaptively controlled conditioning; Autism; Medial temporal amnesia; mGluR; Laminar cortic
Peroxisome proliferator activated receptor gamma (PPARγ) as a therapeutic target for improvement of cognitive performance in Fragile-X
Keywords: AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CNS; central nervous system; ECM; extra cellular matrix; FMR1 gene; Fragile X mental retardation 1 gene; FMRP; Fragile-X mental retardation protein; FXS; Fragile X syndrome; GLUT-3; gl
Downregulation of Homer1b/c improves neuronal survival after traumatic neuronal injury
Keywords: AOD; average optical density; AUC; area under curve; CC; coiled-coil; ER; endoplasmic reticulum; EVH-1; Ena/VASP homology 1; HBSS; Hanks' balanced salt solution; IP3R; inositol 1,4,5-triphosphate receptors; LDH; lactate dehydrogenase; mGluR; metabotropi
Research reportmGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T- and Y-maze cognitive tests
Keywords: ANOVA; analyses of variance; GRM3; mGluR3 gene; KO; knockout; mGluR; metabotropic glutamate receptor; MK-801; dizocilpine; NMDA; N-methyl-d-aspartate; WT; wildtype; mGlu3 receptor; Mouse; Working memory; Side bias; Left-right asymmetry; Dizocilpine;
Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity
Keywords: Astrocyte; mGluR; Power law; Calcium; Modulation;
Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures
Keywords: Early life seizure; Long-term depression; Metabotropic glutamate receptor; CaMKII; Voltage-gated calcium channels; Autism; ACSF; artificial cerebral spinal fluid; APV; amino-5-phosphonopentanoic acid; CaMKII; calcium-calmodulin kinase II; DMSO; dimethyl s
Generating bursts (and pauses) in the dopamine midbrain neurons
Keywords: ACS; air-puff-predictive conditioned stimulus; EGTA; ethylene glycol tetraacetic acid; GPCR; G-protein coupled receptor; IP3; inositoltriphosphate; ISI; inter-spike interval; LDT; lateral dorsal tegmentum; mGluR; metabotropic glutamate receptor; mPFC; med
GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model
Keywords: 2iL; 2nd instar larval; AEL; after egg lay; ANOVA; analysis of variance; APL; anterior paired lateral; BSA; bovine serum albumin; ChAT; choline acetyltransferase; CSÂ +; conditioned stimulus; CSÂ â; control stimulus; dBrainbow; Drosophila Brainbow; dfmr
AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization
Keywords: [Ca2+]i; intracellular Ca2+ concentration; CDZ; chlordiazepoxide; 95% CI; 95-percent confidence interval (as obtained with best-curve fitting); FLIPR; Fluorescence Imaging Plate Reader⢠(assay); GABAB; gamma-amino butyric acid receptor, subtype B; l-Glu
Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus
Keywords: ACh; acetylcholine; ACSF; artificial cerebrospinal fluid; Atrp; atropine; BIC; bicuculline; D-AP5; d-(â)-2-amino-5-phosphonopentanoic acid; DMSO; dimethyl sulfoxide; fEPSPs; field excitatory postsynaptic potentials; HFS; high-frequency stimulation; IBI;
The interaction between mGluR1 and the calcium channel CaV2.1 preserves coupling in the presence of long Homer proteins
Keywords: G protein coupled receptor; Calcium channel; Sympathetic neuron; Pharmacology; mGluR; Metabotropic glutamate receptor; SCG; Superior cervical ganglion; Glu; l-Glutamate;
Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target
Keywords: Major depression; Cognitive flexibility; Hippocampus; Neuronal plasticity; mGlu2; MDD; Major depressive disorder; mGluR; metabotropic glutamate receptor; 5-CSRT; 5-choice- serial reaction time; TRD; treatment resistant depression; BDD; bipolar depressive
Transcriptional changes in rat α-motoneurons resulting from increased physical activity
Keywords: ATE; acute exercise training; AHP; afterhyperpolarization; BDNF; brain-derived neurotrophic factor; GEA; Gene Expression Assay; LCM; laser capture microdissection; mGluR; glutamate receptor, metabotropic; NT-3; neurotrophin-3; PGC-1α; peroxisome prolifer
Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration
Keywords: Escalation; Methamphetamine; mGluR; Reinstatement;
Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; analysis of variance; BSA; bovine serum albumin; DG; dentate gyrus; EAAT1/GLAST; excitatory amino acid transporter 1; KO; knockout; LY354740; (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome
Keywords: AMPAr; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CLS; Coffin-Lowry syndrome; CREB; cAMP-response element binding protein; CS; Conditioned stimulus; EM; Electron microscopy; EPSC; Excitatory postsynaptic currents; ERK; Extracellular
Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin
Keywords: aCSF; artificial cerebrospinal fluid; CED; Cambridge Electronic Design; DHPG; dihydroxyphenylglycine; fEPSPs; field excitatory synaptic potentials; HRP; horseradish peroxidase; LTD; long-term depression; LTP; long-term potentiation; MG132; N-[(phenylmetho
The application of nonlinear Dynamic Causal Modelling for fMRI in subjects at high genetic risk of schizophrenia
Keywords: ACC; Anterior cingulate cortex; BMA; Bayesian Model Averaging; BMS; Bayesian Model Selection; DCM; Dynamic Causal Modelling; EHRS; Edinburgh High Risk Study; IFG; Inferior frontal gyrus; IPS; Intra parietal sulcus; HRÂ +; High risk subjects with psychotic
The NMDA receptor as a target for cognitive enhancement
Keywords: Synaptic plasticity; NMDA receptor; Cognitive enhancement; LTP; Synaptic transmission; Hippocampus; Positive allosteric modulators; AChR; acetylcholine receptor; AKAP79/150; A-kinase anchoring proteins; AMPAR; AMPA receptor; CaMKII; Ca2+/calmodulin-depend
Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
Keywords: Cell commitment; Cell survival; Endocannabinoids; Membrane receptors; Niche cues; Protein kinases; Transcription factors; 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonoylethanolamine; BDNF; brain derived neurotrophic factor; CBD; cannabidiol; CBG; cannab
mGluR1/5 receptor densities in the brains of alcoholic subjects: A whole-hemisphere autoradiography study
Keywords: Cloninger type 1 and 2 alcoholics; Stress; Alcoholism; Glutamate; Metabotropic; mGluR
mGluR1,5 activation protects cortical astrocytes and GABAergic neurons from ischemia-induced impairment
Keywords: Ischemia; mGluR; Astrocyte; GABA neuron; Glutamate transporter; Action potential; Synaptic transmission
Vertebrate extracellular calcium-sensing receptor evolution: Selection in relation to life history and habitat
Keywords: CaSR; calcium-sensing receptor; CRD; cysteine-rich domain; ECD; extracellular domain; GABABR; γ-aminobutyric acid type B receptor; GPCR; G protein-coupled receptor; ICD; intracellular domain; LRT; likelihood ratio test; MAP; mitogen-activated protein (ki
Differential regulation of voltage-gated Ca2+ currents and metabotropic glutamate receptor activity by measles virus infection in rat cortical neurons
Keywords: Measles virus; Voltage-gated calcium channel; DHPG; NMDA; mGluR; Fura-2; Neurons;
Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders
Keywords: mGluR; Kainate; NMDA; SHANK; Neuroligin; PSD-95; MPEP
A form of synaptically induced metabotropic glutamate receptor-dependent long-term depression that does not require postsynaptic calcium
Keywords: CA1; Hippocampus; LTP; LTD; mGluR; Plasticity
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice
Keywords: AMN082; N,Nâ²-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride; BEC; blood ethanol concentrations; CPP; conditioned place preference; mGluR; metabotropic glutamate receptor; MMPIP; 6-(4-methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin
Scaffold protein Homer 1: Implications for neurological diseases
Keywords: EVH1; Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1; IEG; immediate-early gene; P motif; proline-containing motif; mGluR; metabotropic glutamate receptor; IP3R; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potentia
Dog bites man or man bites dog? The enigma of the amino acid conjugations
Keywords: BA; benzoic acid; PAA; phenylacetic acid; HA; hippuric acid; GLY; glycine; GLN; glutamine; TAU; taurine; GLU; glutamic acid; EAA; excitatory amino acid; IAA; inhibitory amino acid; EAAT; excitatory amino acid transporter; ECF; extracellular fluid; CSF; ce
The increased expression of metabotropic glutamate receptor 5 in subventricular zone neural progenitor cells and enhanced neurogenesis in a rat model of intracerebral hemorrhage
Keywords: mGluR5; CHPG; intracerebral hemorrhage; neurogenesis; rat; BDNF; brain derived neurophic factor; bFGF; basic fibroblast growth factor; BMSCs; bone marrow derived stroma cells; BrdU; 5-bromo-2â²-deoxyuridine; CHPG; (R,S)-2-chloro-5-hydroxyphenylglycine; C
Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors
Keywords: AQP; aquaporin; BBB; blood-brain-barrier; COX-2; cyclooxegenase-2; CX43; connexin 43; DAPC; dystrophin-associated protein complex; GFAP; glial fibrilary acidic protein; Kir4.1; K+ channel 4.1; mGluR; metabotropic glutamate receptor; NF-κB; nuclear fact
Targeted treatments in autism and fragile X syndrome
Keywords: Fragile X syndrome; Autism; mGluR; GABA; Treatment