دانلود مقالات ISI درباره Prpc + ترجمه فارسی

Developmental expression of cellular prion protein and apoptotic molecules in the rat cerebellum: Effects of platinum compounds

Keywords: cisPt; cisplatin; EGL; external granular layer; IGL; internal granular layer; ML; molecular layer; PCL; Purkinje cell layer; PD; postnatal day; PrPc; cellular prion protein; Pt; platinum; PtAcacDMS; [Pt(O,O′-acac)(γ-acac)(DMS)]; Cellular prion protein;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice

Keywords: PrPc; cellular prion protein; PrPSc; prion protein scrapie; rAd; recombinant adenovirus; TSE; transmissible spongiform encephalopathy; AA; amino acid; Wt; wild-type; CTL; cytotoxic T lymphocytes; CNS; central nervous system; OligoCpG; oligodeoxy nucleotid

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular cloning and polymorphism analysis of the prion protein gene in Tan sheep of Ningxia, China

Keywords: TSE; transmissible spongiform encephalopathies; CJD; Creutzfeldt-Jakob disease; BSE; bovine spongiform encephalopathy; PrP; prion protein; PrPc; cellular prion protein; PRNP; prion protein gene; SNPs; single nucleotide polymorphisms; ARQ; A136R154Q171;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells

Keywords: Prion diseases; Transmissible spongiform encephalopathies; Anti-prion compound; 2,3,4,9-Tetrahydro-1H-carbazole; Ring-opening reaction; Structure-activity relationships; TSEs; transmissible spongiform encephalopathies; CJD; Creutzfeldt-Jakob disease;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Salt bridges in prion proteins are necessary for high-affinity binding to the monoclonal antibody T2

Keywords: BSE; bovine spongiform encephalopathy; CD; circular dichroism; ka; association rate constant; kd; dissociation rate constant; KD; dissociation constant; PAGE; polyacrylamide gel electrophoresis; PrP; prion protein; PrPC; cellular prion protein; PrPSc; abn

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Alteration of the endocannabinoid system in mouse brain during prion disease

Keywords: prion; endocannabinoid; cannabinoid receptor; neurodegenerative disease; brain; mouse; AEA; arachidonoylethanolamide or anandamide; CBD; cannabidiol; CBR; cannabinoid receptor; CJD; Creutzfeldt-Jakob disease; GAPDH; glyceraldehyde-3-phosphate dehydrogenas

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The pathological prion protein forms ionic conductance in lipid bilayer

Keywords: CNS; central nervous system; TSEs; transmissible spongiform encephalopathies; PrPTSE; pathologic isoform of the prion protein; PrPC; physiologic isoform of the prion protein; PrP27-30; protease resistant core of pathologic PrP; Prion; Transmissible spon

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Tau inhibits tubulin oligomerization induced by prion protein

Keywords: AD; Alzheimer disease; CBB; Coomassie brilliant blue; CtmPrP; transmembrane form of prion protein with the C-terminus residing in the lumen of endoplasmic reticulum; cytoPrP; cytosolic prion protein; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; ER;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Cellular prion protein overexpression disturbs cellular homeostasis in SH-SY5Y neuroblastoma cells but does not alter p53 expression: a proteomic study

Keywords: prion protein; signal transduction; cytoskeleton; protein folding; annexin V; transgelin 2; ADHX; alcohol dehydrogenase class III; ANXA5; annexin V; CV028; UPF0027 protein; DMEM; Dulbecco's modified Eagle medium; FCS; fetal calf serum; FKBP4; FK506-bindin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro

Keywords: Transmissible spongiform encephalopathy; Prion; Prion protein; Conformational conversion; Glycophosphatidylinositol anchor; GPI; glycophosphatidylinositol; NBH; normal hamster brain homogenate; PI-PLC; phosphatidylinositol-specific phospholipase C; PK; pr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source

Keywords: Prion; Transmissible spongiform encephalopathy; PrPC; PrPSc; Protein misfolding cyclic amplification; Transgenic mice

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Enhanced prion protein stability coupled to DNA recognition and milieu acidification

Keywords: PrP; prion protein; PrPSc; prion scrapie; mrPrP; recombinant murine prion protein; PrPC; cellular prion protein; TSEs; transmissible spongiform encephalopathies; GdmCl; guanidinium chloride; NA; nucleic acid.; Prion; DNA; Stability; Unfolding; pH; Urea; G

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

α-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts

Keywords: ADAM; a disintegrin and metalloprotease; Endo H; Endoglycosidase H; ER; endoplasmic reticulum; GPI; glycosyl-phosphatidylinositol; PBS; phosphate-buffered saline; PNGase F; peptide N-glycosidase F; PrPC; cellular form of prion protein; PrPSc; infectious,

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells

Keywords: Adenovirus; Scrapie; Prion; PrPC; Virus; RNA interference

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Utility of RNAi-mediated prnp gene silencing in neuroblastoma cells permanently infected by prions: Potentials and limitations

Keywords: Prion; PrPC; PrPSc; RNAi; siRNA; shRNA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Cellular prion protein modulates age-related behavioral and neurochemical alterations in mice

Keywords: aging; cellular prion protein (PrPC); behavior; acetylcholinesterase (AChE); synaptophysin; caspase-3; AChE; acetylcholinesterase; AD; Alzheimer's disease; ANOVA; analysis of variance; DAB; 3,3′-diaminobenzidine; DG; dentate gyrus; DTNB; dithiobisnitrob

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

PrPC interacts with tetraspanin-7 through bovine PrP154–182 containing alpha-helix 1

Keywords: TSE, Transmissible spongiform encephalopathies; BSE, bovine spongiform encephalopathy; CJD, Creutzfeldt–Jacob diseasePrion; PrPC; Tetraspanin; Transmembrane protein; CD231

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

Keywords: AASA; aminoadipic semialdehyde; BSE; bovine spongiform encephalopathy; CEL; N-ɛ-carboxyethyllysine; CJD; Creutzfeldt-Jakob disease; CML; N-ɛ-carboxymethyllysine; DBI; double bond index; GSA; glutamic semialdehyde, 4-HNE, 4-hydroxynonenal; MCO; metal-cat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Research ReportMild cognitive deficits associated to neocortical microgyria in mice with genetic deletion of cellular prion protein

Keywords: PrPC; cellular prion protein; Prnp; gene that codify PrPC protein; Prnp+/+; PrPC expressing mouse; Prnp0/0; PrPC-null mice; FL; freeze-lesion; MCD; malformation of cortical development; LTP; long-term potentiation; LTM; long-term memory; STM; short-term m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Mouse-adapted sporadic human Creutzfeldt–Jakob disease prions propagate in cell culture

Keywords: Prion protein; PrPC; PrPSc; Transmissible spongiform encephalopathy; Creutzfeldt–Jakob disease

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Copper-induced structural changes in the ovine prion protein are influenced by a polymorphism at codon 112

Keywords: PrPC; Polymorphism; Transmissible spongiform encephalopathies; β-sheet; Conformational stability

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

CRBL cells: Establishment, characterization and susceptibility to prion infection

Keywords: PrP; prion protein; PrPC; cellular prion protein; PrPSc; scrapie prion protein disease; CJD; Creutzfeldt-Jakob; p53−/−; p53 null; CRBL; a cell line established from the cerebellum; N2a; Neuro2a; ScN2a; scrapie-infected N2a; SMB; scrapie-infected mouse

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides

Keywords: PrP; prion protein; PrPC; “cellular” isoform; PrPSc; “scrapie” isoform; TFE; trifluoroethanol; PBS; phosphate buffer solution; TFE/PBS; 87/13 (v/v) TFE/PBS mixture; CD; circular dichroism; NMR; nuclear magnetic resonance; CSD; chemical shift diffe

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

The ubiquitin-proteasome system in spongiform degenerative disorders

Keywords: AD; Alzheimer's disease; AgRP; Agouti related protein; AIDS; acquired immune deficiency syndrome; APP; amyloid precursor protein; ASPA; aspartoacylase gene; Atrn; attractin; BSE; bovine spongiform encephalopathy; CD; Canavan's spongiform leukodystroph

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2008 سفارش ترجمه

Species barriers for chronic wasting disease by in vitro conversion of prion protein

Keywords: CWD; PrPC; PrPSc; In vitro conversion; Species barrier

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Expression and Localization of Cellular Prion and COMMD1 Proteins in Human Placenta throughout Pregnancy

Keywords: PrPC; COMMD1; Copper homeostasis; Human placenta

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Cellular prion protein in ovine milk

Keywords: Prion; PrPC; Milk; Ovine

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Developmental expression of PrP in the post-implantation embryo

Keywords: Prnp; gene encoding the prion protein; PrP; prion protein; PrPC; normal, cellular prion protein; SHa; Syrian hamster; Tg; transgenic; Mo; mouse; CJD; Creutzfeldt-Jakob disease; Prion; Prnp; Expression regulation; Transgenic mice; β-galactosidase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

C1q binding and complement activation by prions and amyloids

Keywords: Alzheimer; Amyloid; C1q; Prion; Scrapie; Transmissible spongiform encephalopathy; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BSE; bovine spongiform encephalopathy; CJD; Creutzfeld-Jacob disease; FBD; familial Briti

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

The neurochemical nature of PrPc-containing cells in the rat brain

Keywords: CB; calbindin; CBP; calcium-binding proteins; CJD; Creutzfeldt-Jakob disease; CR; calretinin; FFI; Fatal Familial Insomnia; PNN; perineuronal nets; PrPC; cellular prion protein; PrPSc; scrapie prion protein; PV; parvalbumin; TSEs; transmissible spongiform

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Structure–activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells

Keywords: Prion; PrP; PrPSc; PrPC; 9-Aminoacridine; Quinacrine; ScN2a

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Antibody-mediated neuronal apoptosis: Therapeutic implications for prion diseases

Keywords: Prion; Anti-prion antibody; Apoptosis; PrPC; PrPSc

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Prion protein mRNA expression in Xenopus laevis: No induction during melanotrope cell activation

Keywords: AL; anterior lobe; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFP; green fluorescent protein; GPI; glycosylphosphatidylinositol; NIL; neurointermediate lobe; POMC; proopiomelanocortin; PrPC; cellular prion protein; Background adaptation; Embryogenes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Rdj2, a J protein family member, interacts with cellular prion PrPC

Keywords: Rdj2; CSPα; J protein; DnaJ/Hsp40 family; PrPC; Prion

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Cell expression of a four extra octarepeat mutated PrPC modifies cell structure and cell cycle regulation

Keywords: PrPC, cellular prion protein; OR, octapeptide repeat; Bo-10ORPrPC, bovine PrPC with a four extra octarepeat insertional mutation; Bo-6ORPrP, normal Bo-PrPC; ORF, open reading frame; Tg, transgenicPrion; PrPC; Cell cycle; Actin cytoskeleton; Apoptosis; Sma

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

FTIR-microspectroscopy of prion-infected nervous tissue

Keywords: Scrapie; PrPSc; PrPC; Synchrotron infrared microspectroscopy; Dorsal root ganglia; Chemical mapping

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

The normal cellular form of prion protein modulates T cell responses

Keywords: PrPC; normally folded prion protein; PrPScabnormally folded prion protein; Prion; T cell; Cytokines; Transfection;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

Bovine PrPC directly interacts with αB-crystalline

Keywords: Protein interaction; Prion; PrPC; αB-Crystalline; Small heat-shock proteinTSE, transmissible spongiform encephalopathies; BSE, bovine spongiform encephalopathy; CJD, Creutzfeldt–Jacob disease; BoPrPC, bovine mature PrPC; sHsp, small heat-shock proteins

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Impaired exercise capacity, but unaltered mitochondrial respiration in skeletal or cardiac muscle of mice lacking cellular prion protein

Keywords: Free radicals; Oxidative stress; Exercise; PrPc;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Mitochondrial localization of cellular prion protein (PrPC) invokes neuronal apoptosis in aged transgenic mice overexpressing PrPC

Keywords: PrPC; Proteasomal activity; Mitochondrial localization; Superoxide dismutase activity; Mitochondria-mediated apoptosis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Female-specific neuroprotection against transient brain ischemia observed in mice devoid of prion protein is abolished by ectopic expression of prion protein-like protein

Keywords: prion protein; prion protein-like protein; ischemia; hippocampus; neuronal death; mouse; Dpl; Doppel; GPI; gylcosylphosphatidylinositol; MCA; middle cerebral artery; PrP; prion protein; PrPC; cellular isoform of prion protein; PrPLP; prion protein-like pr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Effects on the serotoninergic system in sub-acute transmissible spongiform encephalopathies: current data, hypotheses, suggestions for experimentation

Keywords: TSEs; sub-acute transmissible spongiform encephalopathies; PrP; prion protein; PrPC; normal protease-sensitive PrP; PrPres; abnormal protease-resistant PrP; 5-HT; serotonin; 5-HIAA; 5-hydroxyindoleacetic acid; TRP; tryptophan; BSP; bovine spastic paresis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Use of a new immunoassay to measure PrPSc levels in scrapie-infected sheep brains reveals PrP genotype-specific differences

Keywords: PK; Proteinase K; CDI; conformation-dependent immunoassay; PrPC; normal PrP; PrPSc; disease-associated PrP; TSE; transmissible spongiform encephalopathy; BSE; bovine spongiform encephalopathy; CNS; central nervous system; LRS; lymphoreticular system; IHC;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Aptamers against extracellular targets for in vivo applications

Keywords: Aptamers; SELEX; In vivo; Therapeutic; Diagnostic; 18F; fluorine 18; 2′F; 2′ fluoro; 2′Ome; 2′O methyl; 99mTc; technetium 99 metastable; AchR; acetylcholine receptor; AMD; age-related macular degeneration; DAG; diacylglycerol; ECM; extracellular m

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Membrane perturbation effects of peptides derived from the N-termini of unprocessed prion proteins

Keywords: PrP; prion protein; PrPC; cellular isoform of PrP; PrPSc; scrapie isoform of PrP; mPrPp; peptide with sequence corresponding to the N-terminus of the mouse prion protein, residues 1-28; bPrPp; peptide with sequence corresponding to the N-terminus of the

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Detection of ultra-low levels of pathologic prion protein in scrapie infected hamster brain homogenates using real-time immuno-PCR

Keywords: BSE; Immuno-PCR; IPCR; Real-time IPCR; Prion; PrPC; PrPSc; Scrapie; TSE;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Expression of PrPC in the rat brain and characterization of a subset of cortical neurons

Keywords: Disorders of the nervous system; Degenerative disease (other); A; anterior complex of the thalamus; CB; calbindin; CBP; calcium-binding proteins; CJD; Creutzfeldt-Jakob disease; CR; calretinin; FFI; fatal familial insomnia; MD; mediodorsal thalamic nucl

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Proper axonal distribution of PrPC depends on cholesterol-sphingomyelin-enriched membrane domains and is developmentally regulated in hippocampal neurons

Keywords: PrPC; cellular prion protein; DRMs; detergent-resistant cholestrerol-sphingolipid rich domains; SM; sphingomyelin; SLs; sphingolipids; GPI; glycosylphosphatidylinositol; FB1; Fumonisin B1; MCD; methyl-β-cyclodextrin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

The prion protein gene: Identifying regulatory signals using marsupial sequence

Keywords: PRNP; prion protein gene; PrP; prion protein; PrPC; normal isoform of prion protein; PrPSc; pathogenic isoform of prion protein; SPRN; Shadow of prion protein gene; Sho; Shadow protein; ORF; open reading frame; PCR; polymerase chain reaction; RT-PCR; reve

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

Is there a role for copper in neurodegenerative diseases?

Keywords: APP; Amyloid-precursor protein; PrPC; Cellular prion protein; COX; Cytochrome c oxidase; SOD; Superoxide dismutase; ROS; Reactive oxygen species; AD; Alzheimer disease; ALS; Amyotrophic lateral sclerosis; CJD; Creutzfeld-Jakob disease; CSF; Cerebrospina

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه