Computational analysis of the structural basis of ligand binding to the crustacean retinoid X receptor
Keywords: RXR; Ligands; Homology; Docking; Neurotransmitters; Naloxone;
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Activities of natural methyl farnesoids on pupariation and metamorphosis of Drosophila melanogaster
Keywords: MF, methyl farnesoate; JH III, methyl epoxyfarnesoate; JH, juvenile hormone; bisJH III, methyl bisepoxyfarnesoate; HMGCR, 3-hydroxy-3-methyl-glutaryl-CoA reductase; Drosophila, Drosophila melanogasterMethyl farnesoate; Ultraspiracle; RXR; HMGCoA reductase
An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation
Keywords: kb; kilobase pair; kD; kilodalton; SL1; splice leader 1; PCR; polymerase chain reaction; RT-PCR; reverse transcriptase polymerase chain reaction; 20E; 20-hydroxyedysone; DBD; DNA binding domain; LBD; ligand binding domain; EcR; rxr; Nuclear receptor; Ecdy
Differential transcription of genes involved in peroxisome proliferation in thicklip grey mullets Chelon labrosus injected with benzo(a)pyrene
Keywords: AOX1; palmitoyl-CoA oxidase; MFP; multifunctional protein; THIO; 3-ketoacyl-CoA thiolase; DECR; Î2,Î4-dienoyl-CoA reductase 2; PMP70; peroxisomal membrane protein of 70Â kDa; CAT; catalase; CYP1A; cytochrome P450 1A; PPAR; peroxisome proliferator activa
Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (tamibarotene)
Keywords: sleep; aging; vitamin A; cholinergic system; transthyretin; ACh; acetylcholine; ANOVA; analysis of variance; ChAT; choline acetyltransferase; EDTA Na2; disodium ethylenediaminetetraacetic acid; EEG; electroencephalogram; EMG; electromyogram; GAPDH; glycer
Suppressed production of methyl farnesoid hormones yields developmental defects and lethality in Drosophila larvae
Keywords: Juvenile hormone; Methyl farnesoate; Ecdysone; Pupation; Molt; Ultraspiracle; RXR; Metamorphosis; Melanization
Vitamin D receptor binds to the ε germline gene promoter and exhibits transrepressive activity
Keywords: Vitamin D receptor; calcitriol; ε germline transcript; class-switch recombination; IgE; histone acetylation; AcH; Acetylated histone; As2O3; Arsenic-(III)-oxide; CH; Constant heavy chain; ChIP; Chromatin immunoprecipitation; CSR; Class-switch recombinati
Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion
Keywords: cerebral ischemia; neuroprotection; pioglitazone; rosiglitazone; PPARγ; ANOVA; analysis of variance; AP-1; activator protein 1; CBF; cerebral blood flow; CT; computed tomography; Ct; cycle threshold; Cu/Zn; copper/zinc; DMSO; dimethyl sulfoxide; FDA; Fed
Retinoid pathway and cancer therapeutics
Keywords: Retinoids; Nuclear receptor; RAR; RXR; All-trans retinoic acid; 9-cis retinoic acid; 13-cis retinoic acid
Peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells
Keywords: Cell line; endometriosis; endometriotic cell; epigenetics; PPARγ; RXR; TSA
Triphenyltin alters lipid homeostasis in females of the ramshorn snail Marisa cornuarietis
Keywords: Fatty acids; Molluscs; RXR; Organotin; Biochemical effects
Interactions of methyl farnesoate and related compounds with a crustacean retinoid X receptor
Keywords: RXR; EcR; Methyl farnesoate; Daphnia; Tributyltin
The absence of a functional peroxisome proliferator-activated receptor-alpha gene in mice enhances motor sensitizing effects of morphine, but not cocaine
Keywords: morphine; cocaine; sensitization; PPAR; neuroinflammation; WY14643; COX-2; cyclooxigenase-2; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; HPA; hypothalamic-pituitary-adrenal; IL-12; interleukin-12; IL-1β; interleukin-1β; IL-2; interl
Augmentation of antibody responses by retinoic acid and costimulatory molecules
Keywords: Ab; antibody; Ag; antigen; AID; activation-induced cytidine deaminase; APC; antigen-presenting cell; BCR; B cell antigen receptor; CSR; class switch recombination; DC; dendritic cell; GC; germinal center; GLT; germ line transcript(ion); Ig; immunoglobulin
Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles
Keywords: Adamantyl arotinoids; Retinoid-related molecules (RRMs); RXR; Apoptosis; Synthesis9cRA, 9-cis-retinoic acid; AdAr, adamantyl arotinoid; atRA, all-trans-retinoic acid; IKK, IκB kinase; JNK, cJun N-terminal kinase; LBD, ligand binding domain; MAPK, mitogen
Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice
Keywords: GPAT1; glycerol-3-phosphate acyltransferase 1; USF-1; upstream stimulatory factor-1; SREBP-1; sterol regulatory element-binding protein-1; ORF; open reading frame; 5â²-RACE; 5â²-Rapid amplification of cDNA ends; siRNA; small interfering RNA; EMSA; Elect
New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
Keywords: ACAT; acyl-CoA:cholesterol acyltransferase; ABC; adenosine triphosphate-binding cassette transporter; ANXA2-CAV1; annexin 2/caveolin 1; apo; apolipoprotein; CVD; cardiovascular disease; CYP7A1; cytochrome P450 family 7 subfamily A polypeptide 1; FPPS; f
All-trans retinoic acid induces nerve regeneration and increases serum and nerve contents of neural growth factor in experimental diabetic neuropathy
Keywords: DM; diabetes mellitus; DRG; dorsal root ganglion; NGF; neural growth factor; PPAR; peroxisome proliferator-activated receptor; RA; retinoic acid; RAR; retinoic acid receptor; RXR; retinoic X receptor; STZ; streptozotocin;
Changes in the expression and subcellular localization of RARα in the rat hippocampus during postnatal development
Keywords: RAR; retinoic acid receptor; atRA; all-trans-retinoid acid; CNS; central nervous system; RA; retinoic acid; LTP; long-term potentiation; LTD; long-term depression; RXR; retinoic X receptor; DG; dentate gyrus; P; postnatal day; CLSM; confocal laser-scannin
New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists
Keywords: Nuclear receptors; Retinoids; RAR; RXR; Agonist; 9-cis-Retinoic acid
Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor γ complex and correlates with liver steatosis
Keywords: ApoC-IV; apolipoprotein C-IV; PPAR; peroxisome proliferators-activated receptor; RXR; retinoid X receptor; VLDL; very low density lipoprotein; SEAP; secreted alkaline phosphatase; EMSA; electrophoretic mobility shift assay; ChIP; chromatin immunoprecipita
Retinoid requirements in the reproduction of zebrafish
Keywords: Retinal; Retinol; Retinyl ester; Retinoic acid; Oocyte; Raldh2; CYP26a; RAR; RXR; Danio rerio
RXR isoforms and endogenous retinoids in the fiddler crab, Uca pugilator
Keywords: RXR; Isoforms; Crustacean; Receptors; Retinoids; EcR; Ponasterone A; Methyl farnesoate
Isolation and expression of the retinoid X receptor from last instar nymphs and adult females of the soft tick Ornithodoros moubata (Acari: Argasidae)
Keywords: RXR; EcR; Nuclear receptor; Ornithodoros moubata; Ecdysteroid; Vitellogenesis; Ecdysis; Molting; Development; Tick
Bile acids and signal transduction: Role in glucose homeostasis
Keywords: CDCA; chenodeoxycholic acid (3α,7α-dihydroxy-5β cholan-24-oic acid); CA; cholic acid (3α,7α,12α-trihydroxy-5β cholan-24-oic acid); DCA; deoxycholic acid (3α,12α-dihydroxy-5β cholan-24-oic acid); LCA; lithocholic acid (3α-monohydroxy-5β cholan-
Synthesis and structure–activity relationship of novel RXR antagonists: Orally active anti-diabetic and anti-obesity agents
Keywords: RXR; Antagonist; Anti-diabetic; Anti-obesity
Synthesis and structure–activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure
Keywords: RXR; Antagonist; Diazepinylbenzoic acid
Involvement of PPARγ in Human Trophoblast Invasion
Keywords: Placenta; Extravillous cytotrophoblast; Oxidised LDL; LOX-1; RXR; LXR; Ligands; Rosiglitazone; Gene expression;
Manipulation of reciprocal salt bridges at the heterodimerization interface alters the dimerization properties of mouse RXRα and PPARγ1
Keywords: Nuclear receptors; Salt bridge; Ligand binding domain; DNA binding domain; PPAR; RXR; Mammalian two-hybrid; Electrophoretic mobility shift assay; HNF4; Pioglitazone; Charge reversal mutation
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia
Keywords: RXR; LXR; Dyslipidemia; ABCA-1; Triglycerides
Exposure to TBT increases accumulation of lipids and alters fatty acid homeostasis in the ramshorn snail Marisa cornuarietis
Keywords: Fatty acids; Lipogenesis; Methyl-testosterone; RXR; Tributyltin
RXR–LXR heterodimer modulators for the potential treatment of dyslipidemia
Keywords: RXR; LXR; Dyslipidemia; ABCA-1; HDL; LDL; Triglycerides; Diabetes
RXRα Regulates the Pregnancy-Specific Glycoprotein 5 Gene Transcription Through a Functional Retinoic Acid Responsive Element
Keywords: Pregnancy-specific glycoproteins; Syncytiotrophoblast; Transcription; RXR; RARE; Retinoids
Rosiglitazone attenuates suppression of RXRα-dependent gene expression in inflamed liver
Keywords: Liver; Inflammation; RXR; JNK; Rosiglitazone; PPARγ; Nuclear exportRXR, retinoid X receptor; PPAR, peroxisome proliferator-activated receptor; NR, nuclear receptor; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; AP-1, activator protein-1; Ntcp, so
Cloning and characterization of the retinoid X receptor from a primitive crustacean Daphnia magna
Keywords: Crustacean; Daphnia; RXR; Hormone; Receptor; Endocrine; Sex determination
Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)
Keywords: SULT; sulfotransferase; hSULT; human sulfotransferase; mSULT; mouse sulfotransferase; rSULT; rat sulfotransferase; SULT2A1; dehydroepiandrosterone sulfotransferase; SULT1A1; simple phenol sulfotransferase; DHEA; dehydroepiandrosterone; MTX; methotrexate;
Imposex induction is mediated through the Retinoid X Receptor signalling pathway in the neogastropod Nucella lapillus
Keywords: Imposex; Nucella lapillus; Mechanism; RXR
Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase
Keywords: retinoic acid; RAR; RXR; MAPK; ischemia; ATRA; all-trans retinoic acid; CA; cornu ammonis; DG; dentate gyrus; ERK; extracellular signal-regulated kinase; Hanks' BSS; Hanks' balanced salt solution; JNK; c-jun-N-terminal kinase; MAPK; mitogen-activated
15-Deoxy-Î12,14-prostaglandin J2 down-regulates CXCR4 on carcinoma cells through PPARγ- and NFκB-mediated pathways
Keywords: CAY10410; 9,10-dihydro-15-deoxy-Î12,14-prostaglandin J2; COX; cyclooxygenase; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; GW9662; 2-chloro-5-nitro-N-phenylbenzamide; IKK; inhibitor of κB kinase; MAPK; mitogen-activated protein ki
EcR and Usp, components of the ecdysteroid nuclear receptor complex, exhibit differential distribution of molecular determinants directing subcellular trafficking
Keywords: 20E; 20-hydroxyecdysone; AF1; activation function 1; AF2; activation function 2; AR; androgen receptor; BiFC; bimolecular fluorescence complementation; CFP; cyan fluorescent protein; CTE; C-terminal extension; DBD; DNA binding domain; EcR; ecdysteroid rec
Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors
Keywords: W; Williams' medium E; KSFM; keratinocyte serum-free medium; Dex; dexamethasone; EGF or E; human epidermal growth factor; PGE or P; pituitary gland extract; C/EBP; CCAAT/enhancer-binding protein; HNF; hepatocyte nuclear factor; RXR; retinoid X receptor;
Farnesoid secretions of dipteran ring glands: What we do know and what we can know
Keywords: Juvenile hormone; Methyl farnesoate; Ring gland; Corpora allata; Drosophila; Ultraspiracle; RXR; Retinoic acidDrosophila, Drosophila melanogaster unless otherwise noted; JH, juvenile hormone
The pleiotropic function of PPARγ in the placenta
Keywords: Placenta; Trophoblasts; PPARγ; RXR; Thiazolidinedione
The liver as a target organ of retinoids
Keywords: RAR; retinoic acid receptor; RXR; retinoid X receptor; RE; retinyl ester; CRBP; cellular retinol-binding protein; atRA; all-trans-retinoic acid; 9cRA; 9-cis-retinoic acid; 3,4-ddRA; 3,4-dd-retinoic acid; 14-HRR; 14-hydroxy-retro-retinol; Retinoid; Liver;
Effects of bisphenol A on thyroid hormone-dependent up-regulation of thyroid hormone receptor α and β and down-regulation of retinoid X receptor γ in Xenopus tail culture
Keywords: Amphibian metamorphosis; Bisphenol A; Endocrine disrupter; RXR; TR
Differentiation and growth inhibition mediated via the RXR:PPARγ heterodimer in colon cancer
Keywords: Colon cancer; RXR; PPAR; Differentiation induction; Growth inhibitionPPARγ, peroxisome proliferator activated receptor gamma; RXR, retinoid x receptor; PPRE, a peroxisome proliferator activated receptor hormone response element; COX-2, prostaglandin-endop
Antiproliferative effects of tocopherols (vitamin E) on murine glioma C6 cells: homologue-specific control of PKC/ERK and cyclin signaling
Keywords: TOCs; tocopherols and tocotrienols; TQs; tocopheryl quinones; CEHCs; carboxyethyl-hydroxychromans; PKC; protein kinase C; PXR; pregnane X receptor; RXR; retinoid X receptor; COX-2; cyclooxygenase-2; PPARγ; peroxisome proliferator activated receptor γ; F
Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development
Keywords: Retinoid-X receptor; Zebrafish; Gene expression; rxra; rxrba; rxrbb; rxrg; Retinoic acid; Rxr; Phylogenetic analysis; Retinoid-X receptor alpha; Retinoid-X receptor beta; Retinoid-X receptor gamma; RXRA; RXRB; RXRG
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site
Keywords: ChIP; chromatin immunoprecipitation; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; EMSA; electrophoretic mobility shift assay; HDAC; histone deacetlyase; 5-HPETE; 5-hydroperoxyeicosatetraenoic acid; 5-LO; 5-lipoxygenase; rANF; rat atrial natriuretic factor; RLU;
Retinoic acid induces expression of SLP-76: Expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells
Keywords: Cell differentiation; SLP-76; Retinoic acid; BLR1; Burkitt's lymphoma receptor-1; CXCR5; CSF-1; colony stimulating factor-1; EGFP; enhanced green fluorescent protein; FMS; CSF-1 receptor; IRES; internal ribosome entry site; NBT; nitroblue tetrazolium; PDG