کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10455031 | 921063 | 2010 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology
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کلمات کلیدی
DOPAC5-HTGenetic knockoutMHPGTh15-HIAAPFCBCG5-hydroxyindole acetic acid - 5-hydroxyindole اسید استیکCeA - CEAEDTA - اتیلن دی آمین تترا استیک اسید Chronic stress - استرس مزمنAnxiety - اضطرابDepression - افسردگیinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینBacille Calmette-Guérin - باسی کالمت گینهanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetumor necrosis factor-alpha - تومور نکروز عامل آلفاDopamine - دوپامینdisodium ethylenediamine tetraacetate - دی اتان دی اتیلن دی آمین تتراسناتdihydroxyphenylacetic acid - دی هیدروکسی فنیل اسیدهای اسیدBehavior - رفتارSerotonin - سروتونینCytokine - سیتوکینNeuroinflammatory - عصب مغزیneuroendocrine - عصبی عضلانیTNF-α - فاکتور نکروز توموری آلفاmedial prefrontal cortex - قشر غده پروسترولlocus coeruleus - لوکوس سیرولئوسPVN - مالیات بر ارزش افزودهMonoamine - مونوآمینHPA - میلی بار یا هکتوپاسکالknockout - ناکاوتnorepinephrine - نوراپی نفرینT-helper type 1 - نوع T-helper 1wild-type - نوع وحشیcentral amygdaloid nucleus - هسته مرکزی amygdaloidparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسhypothalamus–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالPathology - پاتولوژی یا آسیب شناسیNeurotransmitter - پیامرسان عصبی یا انتقال دهنده عصبی HPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pro-inflammatory cytokines promote behavioral and neurochemical variations similar to those evident following stressor exposure, and have been implicated in promoting depressive illness. Indeed, immunotherapeutic application of the cytokine, interferon-alpha, promoted depressive illness in cancer and hepatitis C patients. We assessed the possibility that another interferon cytokine family member, interferon-gamma (IFN-γ), might contribute to the behavioral and biochemical alterations provoked by a chronic stressor regimen that has been used to model neuropsychiatric pathology in rodents. As predicted, IFN-γ-deficient mice displayed basal differences in behavior (e.g., reduced open field exploration) and altered neurochemical activity (e.g., increased noradrenergic and serotonergic activity within the central amygdala), relative to their wild-type counterparts. Moreover, stressor-induced elevations of corticosterone and the pro-inflammatory cytokine, tumor necrosis factor-alpha, were attenuated in IFN-γ-deficient mice. Similarly, the IFN-γ null mice were refractory to the chronic stressor-induced alterations of dopamine metabolism (within the prefrontal cortex, paraventricular nucleus of the hypothalamus and central amygdala) evident in wild-type mice. Yet, the chronic stressor provoked signs of anxiety (e.g., reduced open field exploration) and depression-like behavior (e.g., increased forced swim immobility, reduced consumption of a palatable solution) among both wild-type and IFN-γ knockout mice alike, suggesting a dissociation of behavioral functioning from the stressor-induced alterations of immunological, hormonal and dopaminergic activity. Together, these data suggest a complex neurobehavioral phenotype, wherein IFN-γ deletion engenders a state of heightened basal emotionality coupled with increased monoaminergic activity in the amygdala. At the same time, however, IFN-γ deficiency appears to blunt some of the neurochemical, corticoid and cytokine alterations ordinarily associated with chronic stressor exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 24, Issue 3, March 2010, Pages 462-473
Journal: Brain, Behavior, and Immunity - Volume 24, Issue 3, March 2010, Pages 462-473
نویسندگان
Darcy Litteljohn, Amie Cummings, Ashley Brennan, Anudip Gill, Siri Chunduri, Hymie Anisman, Shawn Hayley,