کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
7825777 1502976 2018 46 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications
ترجمه فارسی عنوان
کوپلیمرهای حاوی پلیارسکوزین: سنتز، مشخصه، خودآموزی و کاربرد
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Although the first polysarcosine (pSar) synthesis by Wesseley et al. was reported almost a century ago, it was only recently that pSar gained broader attention and is considered a potential alternative of poly(ethylene glycol) (PEG). In contrast to polyethers, such as PEG, pSar is a polypeptoid based on the amino acid sarcosine, i.e. N-methylated glycine. As a polymer, pSar combines PEG-like properties, e.g., excellent solubility in water, protein resistance, low cellular toxicity and a non-immunogenic character, while being based on endogenous material. Sarcosine can be obtained in a simple one-step reaction of bromoacetic acid and methylamine, easily transferred into the sarcosine N-(thio)carboxyanhydride and polymerized under living condition. This review provides a first comprehensive overview on pSar-containing block copolymers, which comprises of copolymers with polyesters, polyethers, polypeptides, polypeptoids, polyacrylates, others, as well as graft copolymers. The synthesis, characteristics and application of such polymers will be presented and discussed in detail. Finally, solution self-assembly and applications of pSar-containing block copolymers are reviewed underlining the enormous potential of this recently rediscovered polypeptoidic material.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Polymer Science - Volume 81, June 2018, Pages 163-208
نویسندگان
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