کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8713258 | 1587104 | 2018 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma
ترجمه فارسی عنوان
بررسی روش های متابولومیکس و کاربرد آنها در شناسایی مسیرهای علمی آسم دوران کودکی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Semiconductor metal oxideMSEASMORSVEBCVOCnuclear magnetic resonance - رزونانس مغناطیسی هستهایHRV - ENGAsthma - آسمVolatile organic compound - ترکیب آلی فرارNMR - تشدید مغناطیسی هستهای Systems approach - رویکرد سیستم هاHuman rhinovirus - رینوویروس انسانیMass spectrometry - طیف سنجی جرمیRespiratory tract infections - عفونت دستگاه تنفسیExhaled breath condensate - مایع مایع نفس کشیدنMetabolomics - متابولومیکExhaled breath - نفس نفس کشیدنRespiratory syncytial virus - ویروس سنسیتیال تنفسیliquid chromatography - کروماتوگرافی مایعGas chromatography - کروماتوگرافی گازی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Because asthma is a disease that results from host-environment interactions, an approach that allows assessment of the effect of the environment on the host is needed to understand the disease. Metabolomics has appealing potential as an application to study pathways to childhood asthma development. The objective of this review is to provide an overview of metabolomics methods and their application to understanding host-environment pathways in asthma development. We reviewed recent literature on advances in metabolomics and their application to study pathways to childhood asthma development. We highlight the (1) potential of metabolomics in understanding the pathogenesis of disease and the discovery of biomarkers; (2) choice of metabolomics techniques, biospecimen handling, and data analysis; (3) application to studying the role of the environment on asthma development; (4) review of metabolomics applied to the outcome of asthma; (5) recommendations for application of metabolomics-based -omics data integration in understanding disease pathogenesis; and (6) limitations. In conclusion, metabolomics allows use of biospecimens to identify useful biomarkers and pathways involved in disease development and subsequently to inform a greater understanding of disease pathogenesis and endotypes and prediction of the clinical course of childhood asthma phenotypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 141, Issue 4, April 2018, Pages 1191-1201
Journal: Journal of Allergy and Clinical Immunology - Volume 141, Issue 4, April 2018, Pages 1191-1201
نویسندگان
Kedir N. PhD, Lindsey PhD, Kelli K. PhD, Tina V. MD, MPH,