دانلود مقالات ISI درباره Gpcrs + ترجمه فارسی

Expression and function of β-arrestin 2 stimulated by IL-1β in human fibroblast-like synoviocytes and the effect of paeoniflorin

Keywords: RA; rheumatoid arthritis; AA; adjuvant arthritis; CIA; collagen-induced arthritis; FLS; fibroblast-like synoviocytes; GPCRs; G-protein-coupled receptors; Pae; paeoniflorin; PBMC; peripheral blood mononuclear cells; MLN; mesenteric lymph nodes; 7TMRs; 7 tr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics

Keywords: Histamine; H4R antagonist; GPCR; Binding kinetics; Fragment optimization; GPCRs; G protein-coupled receptors; H1R; histamine H1 receptor; H2R; histamine H2 receptor; H3R; histamine H3 receptor; H4R; histamine H4 receptor; SAR; structure-activity relatio

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Using core hydrophobicity to identify phosphorylation sites of human G protein-coupled receptors

Keywords: Human G protein-coupled receptors; Phosphorylation; Amino acid hydrophobicity; Support vector machines; GPCRs; G protein-coupled receptors; SVM; Support vector machine; MCC; Matthews correlation coefficient; AUC; Area under the curve; ROC; Receiver operat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB)

Keywords: GPCRs; Basal ganglia; Globus pallidus; Substantia nigra; Retrograde tracing; Parkinson disease;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio)

Keywords: NKB; neurokinin B; GnRH; gonadotropin releasing hormone; CRE; cAMP response element; SRE; serum response element; SP; substance P; NKA; neurokinin A; HK-1; hemokinin-1; EK; endokinin; GPCRs; G protein-coupled receptors; NK1; tachykinin-1 receptor; NK2; ta

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Reversal of inhibition of putative dopaminergic neurons of the ventral tegmental area: Interaction of GABAB and D2 receptors

Keywords: aCSF; artificial cerebrospinal fluid; CGP35348; (3-aminopropyl)(diethoxymethyl)phosphinic acid; DA; dopamine; DAergic; dopaminergic; DIR; dopamine inhibition reversal; GIRKs; G-protein-linked inwardly rectifying potassium channels; Gö6976; 5,6,7,13-tetra

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures

Keywords: Microvesicles; Inter-cellular communication; GPCRs; Exosomes; Synaptic modulation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ETA-receptor expression

Keywords: AG; aminoguanidine; AGEs; advanced glycation end-products; CML; N epsilon-(carboxymethyl) lysine; ECE1; endothelin converting enzyme; ERK; extracellular signal-regulated kinase; ET-1; endothelin-1; ETA-R; endothelin type A receptor; ETB-R; endothelin type

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness

Keywords: Asthma; airway hyperresponsiveness; airway smooth muscle mass; airway smooth muscle contraction; Ca2+ mobilization; extracellular signal-regulated kinase; G protein-coupled receptors; knockout mice; ovalbumin-sensitized/-challenged murine model of asth

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Distribution and localisation of Gα proteins in the rostral ventrolateral medulla of normotensive and hypertensive rats: Focus on catecholaminergic neurons

Keywords: AP; alkaline phosphatase; Ct; cycle threshold; DIG; digoxigenin; GPCRs; G-protein-coupled receptors; IHC; immunohistochemistry; ISH; in situ hybridisation; LC; locus coeruleus; NSE; neuron specific enolase; rC1; rostral C1; RVLM; rostral ventrolateral med

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila

Keywords: GPCRs; G protein-coupled receptors; CHO; Chinese hamster ovary; CM; carboxymethyl; ACN; acetonitrile; TFA; trifluoroacetic acid; PTH; phenyl thiohydantoin; GPCR; Cysteine-rich peptide; Drosophila;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy

Keywords: G proteins; GTPases; GPCRs; Phosphatidic acid; Phospholipase D; Phospholipase C-β; RhoA;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Cyclooxygenases and 5-lipoxygenase in Alzheimer's disease

Keywords: AA; arachidonic acid; AD; Alzheimer's disease; CNS; central nervous system; COXs; cyclooxygenases; CysLT1; cysteinyl leukotriene 1; EP; prostaglandin E receptor; GPCRs; G protein-coupled receptors; 5-LOX; 5-lipoxygenase; LTB4; leukotriene B4; LXA4; lipoxi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes

Keywords: GPCRs; G protein-coupled receptors; GRKs; G protein-coupled receptor kinases; PKA; protein kinase A; Dopamine D1 receptor; Palmitoylation; Caveolae; Clathrin; Endocytosis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Evidence for the presence of a critical disulfide bond in the mouse EP3γ receptor

Keywords: mEP3γ; mouse E-prostanoid receptor subtype 3 gamma; PGE2; prostaglandin E2; HA; hemagglutinin epitope tag; Prostaglandin E2; Mutagenesis; Cysteine; Disulfide bond; GPCRs;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The expression change of β-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony

Keywords: TGP; total glucosides of paeony; RA; rheumatoid arthritis; CIA; collagen-induced arthritis; GRK; G-protein-coupled receptor kinases; FLS; fibroblast-like synoviocytes; GTW; glucosides of tripterygium wilfordii; GPCRs; G protein-coupled receptors; AA; adju

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

How vaccinia virus has evolved to subvert the host immune response

Keywords: Bcl-2; B-cell lymphoma-2; CPXV; Cowpox virus; dsDNA; double-stranded DNA; ECTV; ectromelia virus; GAGs; glycosaminoglycans; GPCRs; G-protein coupled receptors; IFN; interferon; IG; immunoglobulin; PDB; protein data bank; RPXV; rabbitpox virus; r.m.s.d.; r

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Identification and differential expression of a sex-peptide receptor in Helicoverpa armigera

Keywords: Male accessory glands; Sex-peptide; Sex-peptide receptor; Moth; Pheromone biosynthesis-activating neuropeptide; Helicoverpa armigera; Acps; accessory gland proteins and peptides; Br; brain-subesophageal ganglion-corpora cardiaca-corpora allata compl

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Muscarinic toxins

Keywords: Muscarinic toxins; Muscarinic receptors; Three-finger fold toxins; GPCRs;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Exploration of structure-based drug design opportunities for mGluRs

Keywords: GPCRs; mGluRs; Transmembrane domain

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Structural and functional roles of small group-conserved amino acids present on helix-H7 in the β2-adrenergic receptor

Keywords: β2-AR; β2-adrenergic receptor; Bmax; Binding maximum of the ligand for the receptor; COS-1; Monkey kidney cells; GPCRs; G protein-coupled receptors; HEK293; human embryonic kidney cells; [3H] DHA; tritium labeled dihydroalprenolol; Kd; equilibrium disso

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins

Keywords: G protein-coupled receptors; GPCRs; Conformational ensemble; Functional selectivity; Protein structure prediction; Transmembrane helix topology

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

A novel, extremely fast, feedback inhibition of glutamate release in the crayfish neuromuscular junction

Keywords: feedback inhibition; GPCRs; mGluRs; neurotransmitter release; glutamate release; presynaptic modulationDI, dose-inhibition; DR, dose-response; ENTC, excitatory nerve terminal current; EPSC, excitatory postsynaptic current; EPSP, excitatory postsynaptic po

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Role of ßarrestins in bradykinin B2 receptor-mediated signalling

Keywords: GPCRs; G protein-coupled receptors; ERK1/2; extracellular signal-regulated protein kinases; BK; bradykinin; B2R; bradykinin type 2 receptor; B2R-4A; B2R where 4 serine and threonine were mutated to alanines (Thr342/345, Ser346/348); GRK; G protein recepto

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of novel signaling components in genistein-regulated signaling pathways by quantitative phosphoproteomics

Keywords: SILAC; stable isotope labeling by amino acids in cell culture; PTM; post-translational modification; SCX; strong-cation exchange chromatography; RSD; relative standard deviation; RTKs; receptor tyrosine kinases; GPCRs; G-protein-coupled receptors; BCLAF1;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Cellular and Molecular NeuroscienceResearch PaperMembrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release

Keywords: Ca2+ channel; TRPC channel; Gq/11 GPCR; PLCβ; depolarization-evoked secretion; LTP; BK; bradykinin; CA; catecholamine; GPCRs; G-protein-coupled receptors; Hist; histamine; IP3; inositol trisphosphate; K60; 60 mM KCl; LTP; long-term potentiation; PI; phos

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors

Keywords: 5-HT1A; 5-serotonin1A; ARs; adrenergic receptors; α1-ARs; α1-adrenergic receptors; GPCRs; G-protein coupled receptors; HBA; hydrogen bond acceptor; MLPInS; molecular lipophilicity potential interaction score; RN5; 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Associate Editor: V.J. WattsRegulation of stem cell pluripotency and differentiation by G protein coupled receptors

Keywords: G protein coupled receptor; GPCR; Pluripotency; Stem cell; Differentiation; EB; Embryoid body; ES cells; Embyronic stem cells; FZD; Frizzled; GPCRs; G protein coupled receptors; GSK3; Glycogen synthase kinase 3; hATSCs; Human adipose tissue-derived mesenc

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5

Keywords: TGR5; GPCRs; Diabetes; Bile acids

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Non-basic ligands for aminergic GPCRs: The discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders

Keywords: 5-HT2A; GPCRs; Non-basic; Diaryl sulfones;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3

Keywords: βARs; beta-adrenergic receptors; PKA; protein kinase A; CT; carboxyl terminus; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular signal-regulated kinase; GPCRs; G-protein-coupled receptors; GST; glutathione S-transferase; His; hexahistidin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery and characterization of [3H]8-OH-DPAT binding to HeLaS3 cells

Keywords: [3H]8-OH-DPAT; 5-HT1A receptor; GPCRs; HeLaS3; Radioligand binding assay

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

A reconstitution protocol for the in vitro folded human G protein-coupled Y2 receptor into lipid environment

Keywords: CD; circular dichroism; CHAPS; 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate; DMPC-d67; 1,2-dimyristoyl-d54-sn-glycero-3-phosphatidylcholine-1,1,2,2-d4-N,N,N-tri-methyl-d9; DDM; n-dodecyl-β-d-maltoside; GPCRs; G protein-coupled receptors; 3H

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?

Keywords: GPCRs; Dimers; Computational methods; Molecular modeling; Rational drug design

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance

Keywords: Lysophospholipids; LPA; S1P; GPCRs; Receptors; Autotaxin; LPP; PRG

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds

Keywords: CNS; central nervous system; CR; chronically restricted diet rats; CV; circumvallate papilla; GPCRs; G-protein-coupled receptors; CT; chorda tympani; HF; high-fat diet induced obese rats; OB-Rb; full-length “b” isoform of the leptin receptor; PLC-β2;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

The G protein-coupled receptors in the silkworm, Bombyx mori

Keywords: GPCRs; Genome survey; Homolog; Drosophila melanogaster; Anopheles gambiae

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Predicted 3D structures for adenosine receptors bound to ligands: Comparison to the crystal structure

Keywords: GPCRs; Adenosine; Structure prediction; Membrane protein structure; Ligand binding; Docking; Modeling; Receptor;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Gα16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS)

Keywords: ERK; extracellular signal-regulated kinase; GPCRs; G protein-coupled receptors; HEK 293; human embryonic kidney 293; IKK; IκB kinase; NFκB; nuclear factor κB; PLCβ; phospholipase Cβ; STAT3; signal transducer and activator of transcription 3; TPR1; te

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

Keywords: GPCRs; G protein-coupled receptors; AR; adenosine receptor; ADA; adenosine deaminase; cAMP; cyclic adenosine monophosphate; h; human; SAR; structure-affinity relationship; r; rat; DPCPX; 8-cyclopentyl-1,3-dipropyl-xanthine; CGS 21680; 2-[4-(2-carboxyeth

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Involvement of NTS2 receptors in stress-induced analgesia

Keywords: neuropeptide; SR142948A; GPCRs; stress disorders; chronic pain; hypothalamic-pituitary-adrenal axisACTH, adrenocorticotropin hormone; CRH, corticotropin-releasing hormone; HPA, hypothalamic-pituitary-adrenal; JMV-431, Boc-Arg-Arg-Pro-TyrΨ (CH2NH)Ile-Leu-O

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

The pattern of expression of guanine nucleotide-binding protein β3 in the retina is conserved across vertebrate species

Keywords: photoreceptor; bipolar cell; transducin; retinopathy; ERG; electroretinogram; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GCL; ganglion cell layer; GNB1; guanine nucleotide-binding protein β1; GNB3; guanine nucleotide-binding protein β3; GPCRs; G-p

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

Neutralizing endogenous chemokines with small molecules

Keywords: BSA; Bovine serum albumin; DARC; Duffy antigen receptor for chemokines; GAG; Glycosaminoglycans; GPCR; G-protein-coupled receptor; IL; Interleukin; LPS; Lipopolysaccharide; MS; Multiple sclerosis; Chemokines; Cytokines; GPCRs; Decoy receptors; Neutralizin

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

Receptor-receptor interactions: A novel concept in brain integration

Keywords: AI; Aggregation Index; AFM; Atomic Force Microscopy; CPs; Check-Points; CHO; Chinese Hamster Ovary; DOR; Delta opioid receptors; DI; Disorder Index; DA; dopamine; GPCRs; G-protein coupled receptors; Hcy; homocysteine; KOR; kappa opioid receptors; LTD; lon

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2010 سفارش ترجمه

Structural models for the complex of chemotaxis inhibitory protein of Staphylococcus aureus with the C5a receptor

Keywords: GPCRs; C5a receptor; Chemotaxis inhibitory protein; Molecular modeling; GPCR; G-protein-coupled receptor; C5a; anaphylotoxin C5a; C5aR; C5a receptor; CHIPS; chemotaxis inhibitory protein of Staphylococcus aureus;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors

Keywords: GPCRs; Allosteric modulators; SAR; Conformational analysis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists

Keywords: Camphor sulfonamides; N-arylpiperazine; CXCR3 receptor antagonists; Chemokine; GPCRs; Inflammation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: In vitro profiling and in vivo evaluation

Keywords: MCH-R1; ATC0175; Obesity; Food intake; GPCRs; PK-PD; CNS;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Syntheses of novel high affinity ligands for opioid receptors

Keywords: Opioid ligands; GPCRs; Bioactive conformation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Molecular characterization and localization of the first tyramine receptor of the American cockroach (Periplaneta americana)

Keywords: biogenic amine; cellular signaling; G-protein-coupled receptor; octopamine; salivary gland; trace amine; AmTYR1; Apis mellifera tyramine receptor; ANOVA; analysis of variance; cAMP; 3′-5′-cyclic AMP; [cAMP]i; intracellular 3′-5′-cyclic AMP con

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه