دانلود مقالات ISI درباره Rmsd + ترجمه فارسی

Structure and characterization of the 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Aeropyrum pernix

Keywords: BTP; 1,3-bis[tris(hydroxymethyl)methylamino]propane; DAH7PS; 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase; DAH7PSAp; the DAH7PS from Aeropyrum pernix; DAH7PSPf; the DAH7PS from Pyrococcus furiosus; DAH7PSTm; the DAH7PS from Thermatoga maritima; DP

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

Keywords: ACHBP; acetylcholine-binding protein; DMXBA; 3-(2,4-dimethoxybenzilidene)-anabaseine; HBD; hydrogen-bond donor; nAChR; nicotinic acetylcholine receptor; Pdb; protein databank; rmsd; root-mean-squared-deviation; ROC; receiver operating characteristic curve

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Structure-based characterization of canine-human chimeric uricases and its evolutionary implications

Keywords: Hominoid uricase; Chimeric construction; Primate evolution; Inactivation process; Multistep mutations; wCU; wild-type canine uricase; dHU; deduced human uricase; LB; Luria-Bertani; RP-HPLC; Reverse-phase high performance liquid chromatography; SE-HPLC; si

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ)

Keywords: STIL protein; Docking; Molecular dynamics simulation; CENPJ protein; STIL; SCL/TAL1 interrupting locus; CENPJ; Centromere protein J; MDS; Molecular dynamics simulation; RMSD; Root-mean-square deviation; Rg; Radius of gyration; SASA; Solvent-accessible sur

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability

Keywords: CDR; complementary determining region; CH; constant domain heavy chain; CL; constant domain light chain; ELISA; enzyme-linked immunosorbent assay; FR; framework region; KD; dissociation constant; RMSD; root mean square deviation; SCM; spectra center of ma

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes

Keywords: AIF; apoptosis-inducing factor, mitochondrion-associated, 1; Apaf-1; apoptotic peptidase activating factor 1; Bax; BCL2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl-extra large; Bid; BH3 interacting domain death agonist; CASP3; caspase-3; C

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Inter-phylum structural conservation of the magnetosome-associated TPR-containing protein, MamA

Keywords: Mbav; Candidatus Magnetobacterium bavaricum; TPR; tetra-trico-peptide repeat; MTB; magnetotactic bacteria; AMB-1; Magnetospirillum magneticum; MSR-1; Magnetospirillum gryphiswaldense; RMSD; root mean square deviation; NTD; N-terminal domain; CTD; C-termin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E

Keywords: CENP-E; centromere-associated protein-E; nsSNPs; non-synonymous single nucleotide polymorphisms; MDS; molecular dynamics simulation; RMSD; root-mean-square deviation; Rg; radius of gyration; SASA; solvent-accessible surface area; RMSF; root-mean square fl

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes

Keywords: MGL; monoacylglycerol lipase; bMGL; monoacylglycerol lipase from Bacillus sp. H257; hMGL; human monoacylglycerol lipase; PMSF; phenylmethylsulfonyl fluoride; SAXS; small angle X-ray scattering; RMSD; root mean square deviation; SDS-PAGE; sodium dodecyl su

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: Synthesis, biochemical and biological assessment

Keywords: Pyrimidine gluconucleosides; Glycogen metabolism; Diabetes type 2; Inhibitor; Glycogen phosphorylase; X-ray crystallography; DMF; N,N-dimethylformamide; CH3CN; acetonitrile; EtOAc; ethyl acetate; n-Bu4NF; n-tetrabutylammonium fluoride; MeOH; methanol; CuI

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells

Keywords: ER-α; estrogen receptor α; SWT; Si-Wu-Tang; SERMs; selective estrogen receptor modulators; ER; estrogen receptor; E2; estradiol; TCM; traditional Chinese medicine; ERE; estrogen regulatory element; MTT; 3-(4,5-dimethythiazol-2-yl)-2, 5-diphenyltetrazoli

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Towards the elucidation of the regulatory network guiding the insulin producing cells' differentiation

Keywords: NGN3 (NEUROG3); neurogenin3; ESCs; Embryonic Stem Cells; TFBS; Transcription Factor Binding Sites; TFs; Transcription Factors; AP4 (TFAP4); Activating enhancer-binding Protein 4 (Transcription Factor AP-4); WISP1; WNT-Induced Secreted Protein 1; CTGF; Con

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: Suppression of serine/threonine and tyrosine kinases

Keywords: AP-1; activator protein 1; C3-toxin; Clostridium botulinum C3 transferase; CE; cytoplasmic extracts; Cox2; cyclooxygenase 2; ICAM; intercellular adhesion molecule; NF-κB; nuclear transcription factor kappaB; IL; interleukin; IκB; inhibitory subunit of N

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The only exoribonuclease present in Haloferax volcanii has an unique response to temperature changes

Keywords: RNase; ribonuclease; CSD; Cold Shock Domain; DTT; Dithiothreitol; EDTA; Ethylenediaminetetraacetic acid; SPR; Surface plasmon resonance; PDB; protein data bank; PNPase; Polynucleotide phosphorylase; PAP I; Poly(A) Polymerase; RMSD; Root mean square deviat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis

Keywords: Human NaPRT; Enzyme kinetics; Homology modeling; Molecular docking; Site-directed mutagenesis; DHAP; dihydroxyacetone phosphate; G3P; glyceraldehyde 3-phosphate; IPTG; isopropyl β-d-1-thiogalactopyranoside; Na; nicotinic acid; Nam; nicotinamide; NamR; ni

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8)

Keywords: ADP; adenosine 5′-diphosphate; BSA; bovine serum albumin; cePOFUT1; Caenorhabditis elegans protein O-fucosyltransferase 1; EGF; epidermal growth factor; Fcγ; fragment, crystallizable gamma; FID; free induction decay; FUT8; human α1,6-fucosyltransferas

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Redox, mutagenic and structural studies of the glutaredoxin/arsenate reductase couple from the cyanobacterium Synechocystis sp. PCC 6803

Keywords: DTNB; 5,5′-dithiobis(2-nitorbenzoic acid); DTTred; reduced dithiothreitol; DTTox; oxidized dithiothreitol; Grx; glutaredoxin; GSH; reduced glutathione; GSSG; oxidized glutathione; MALDI-TOF; Matrix Assisted Laser Desorption/Ionization-Time of Flight; ma

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of the critical structural determinants of the EF-hand domain arrangements in calcium binding proteins

Keywords: Ca2+; calcium; CaBPs; calcium binding proteins; CaM; calmodulin; CNB; calcineurin B; SCP; sarcoplasmic calcium binding protein; TnC; troponin C; TnI; troponin I; TnT; troponin T; Tn; troponin; hCLP; human calmodulin-like protein; CIB1; calcium and integri

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Comparative modeling of HGPRT enzyme of L. donovani and binding affinities of different analogs of GMP

Keywords: HGPRT; hypoxanthine-guanine phosphoribosyl transferase; HPRT; hypoxanthine phosphoribosyltransferase; CL; cutaneous leishmaniasis; MCL; muco-cutaneous leishmaniasis; VL; visceral leishmaniasis; PKDL; post-kala-azar dermal leishmaniasis; BLAST; basic local

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Lipid shape is a key factor for membrane interactions of amphipathic helical peptides

Keywords: AMP; antimicrobial peptide; CHOL; Cholesterol; DLPC; 1,2-dilauroyl-sn-glycero-3-phosphatidylcholine; DMPC; 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine; DMPG; 1,2-dimyristoyl-sn-glycero-3-phosphatidylglycerol; DMoPC; 1,2-dimyristoleoyl-sn-glycero-3-ph

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Ginsenoside Rg1 protection against β-amyloid peptide-induced neuronal apoptosis via estrogen receptor α and glucocorticoid receptor-dependent anti-protein nitration pathway

Keywords: β-Amyloid; Receptor nuclear translocation; Ginsenoside Rg1; Protein tyrosine nitration; ERK1/2 phosphorylation; Ach; acetylcholine; AD; Alzheimer's disease; AO; acridine orange; Aβ25-35; β-amyloid peptide25-35; carboxy-DCFDA; 5-(and-6)-carboxy-2â

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Calpains - An elaborate proteolytic system

Keywords: aa; amino acid(s); C2; C2 domain; C2L; C2 domain-like domain; CAPN; calpain; CysPc; calpain-like cysteine protease sequence motif defined in the conserved domain database at the National Center for Biotechnology Information (cd00044); PEF; penta EF-hand;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Valine 44 and valine 45 of human glutathione synthetase are key for subunit stability and negative cooperativity

Keywords: hGS; human glutathione synthetase; GSH; glutathione; γ-GluABA; γ-glutamyl-α-aminobutyrate; IPTG; isopropyl-1-thio-β-d-galactopyranoside; MCAC; metal chelate affinity chromatography; DSC; differential scanning calorimetry; MOE; molecular operating envi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Blockage of the channel to heme by the E87 side chain in the GAF domain of Mycobacterium tuberculosis DosS confers the unique sensitivity of DosS to oxygen

Keywords: DosS; dormancy survival regulator sensor; DevS; differently expressed in virulent strain; GAF; GMP-regulated cyclic nucleotide phosphodiesterases, Anabaena adenylyl cyclase and bacterial transcription factor FhlA; S-GAF; the first GAF domain of DosS; T-GA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway

Keywords: PTIP; Pax2 transactivation domain interaction protein; BRCT; BRCA1 C-terminal domain; DDR; DNA damage response; IR; ionizing radiation; FPA; fluorescence polarization assays; IRIF; ionizing radiation-induced focus; RMSD; root mean-square deviation; PA1; P

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1

Keywords: NSD; nuclear receptor binding SET domain; HMTase; histone-lysine methyltransferase; AdoMET; S-adenosylmethionine; MD; molecular dynamics; RMSD; root mean square deviation; Epigenetic therapy of cancer; Histone-lysine methyltransferase; NSD1; NSD2/MMSET/WH

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Water transport in human aquaporin-4: Molecular dynamics (MD) simulations

Keywords: MD; molecular dynamics; SMD; steered MD; PDB; protein data bank; RMSD; root mean-squared deviation; POPC; palmitoyl-oleoyl-phosphatidyl-choline; PSF; protein structure file; NPA; Asn-Pro-Ala; PME; Particle Mesh Ewald; BD-FDT; brownian dynamics fluctuation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The enzymatic reaction-induced configuration change of the prosthetic group PQQ of methanol dehydrogenase

Keywords: MEDH; methanol dehydrogenase; PQQ; pyrroloquinoline quinone; MEDH-WA; methanol dehydrogenase from Methylophilus W3A1; MWA-A, MWA-B and MWA-C; crystals of MEDH-WA in forms A, B and C, respectively, grown in the presence of methanol at low concentration; MW

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Role of aromatic stack pairing at the catalytic site of gelonin protein

Keywords: Aromatic stack pairing; Ribosome inactivating protein; Gelonin; Mutagenesis; RMSD; Molecular dynamics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes

Keywords: CTL; cytotoxic T lymphocyte; HIV; human immunodeficiency virus; HLA; human leukocyte antigen; RMSD; root mean square deviation; TCR; T cell receptor; HLA-A*0301; HLA-A*1101; HLA-A3 supertype; Crystal structure; Cross-presentation; T cell epitopes; IMGT;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Insights into the structural properties of d-serine dehydratase from Saccharomyces cerevisiae: An FT-IR spectroscopic and in silico approach

Keywords: Infrared spectroscopy; d-serine dehydratase; Saccharomyces cerevisiae; Pyridoxal-5′-phosphate-dependent enzymes; Protein structure; FT-IR; Fourier Transform infrared; Dsd; d-serine dehydratase; PLP; Pyridoxal-5′-phosphate; SMR; Swiss Model Repository;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Potential virtual lead identification in the discovery of renin inhibitors: Application of ligand and structure-based pharmacophore modeling approaches

Keywords: Ligand and structure-based pharmacophore; Renin; Blood pressure; Database screening; Molecular docking; RAS; renin-angiotensinogen system; ACE; angiotensin-converting enzyme; PDB; protein data bank; DS; discovery studio; Pharm-A; pharmacophore A; HA; hydr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: The carbohydrate binding mechanism involves residual sialidase activity

Keywords: TS; trans-sialidase; iTS; inactive trans-sialidase-like lectin; rmsd; root mean squared deviation; 4-MUNANA; 4-methylumbelliferyl-N-acetyl-neuraminic acid; SPR; surface plasmon resonance; wt; wild-type; RU; resonance unit; Lectin; Trypanosoma; Sialic acid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

Keywords: AKR; aldoketoreductase; ALR1; aldehyde reductase; ALR2; aldose reductase; ARI; aldose reductase inhibitor; PKC; protein kinase C; rmsd; root-mean squared deviation; SDH; sorbitol dehydrogenase; Aldose and aldehyde reductase; ARI; Long-term diabetic compli

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular architecture of mouse activating NKR-P1 receptors

Keywords: Clr; C-type lectin receptor; CTLD; C-type lectin like domain; DLS; dynamic light scattering; DSC; differential scanning calorimetry; DTT; dithiothreitol; EDC; 1-ethyl-3-(3′-dimethylaminopropyl) carbodiimide; FT-MS; Fourier-transform mass spectrometry; I

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp.

Keywords: AHR; Aryl hydrocarbon receptor; BNF; ß-naphthoflavone; CYP1A; Cytochrome P450 1A; DMBA; 7,12-dimethylbenz[α]anthracene; DMSO; Dimethyl sulfoxide; ER; Ethoxyresorufin; EROD; Ethoxyresorufin-O-deethylase; i.p.; intraperitoneally; ITS; internal transcribed

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose

Keywords: BGC; β-d-glucose; CBI; cellobiose; CTT; cellotetraose; MAT; mannotriose; PEG; polyethyleneglycol; PCR; polymerase chain reaction; RMSD; root mean square deviation; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; Tris; tris (hydroxyme

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Analyzing speech of patients with vocal polyps based on channel parameters and fuzzy logic systems

Keywords: Fuzzy logic systems; Polypus; RMSD; Standard deviation; SVM

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Structural and functional comparison of cytokine interleukin-1 beta from chicken and human

Keywords: ANS; 8-anilino-1-naphthalenesulfonicacid; IL-1β; interleukin-1β; IL-1R type I; type I interleukin-1 receptor; CD; circular dichroism; rmsd; root mean square deviation; Chicken interleukin-1β; Interleukin-1 receptor type I; Chemokine K60; Plasma cortiso

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase: Implications for the catalytic and inactivation mechanisms

Keywords: Ap; ampicillin; BICINE; N,N-Bis(2-hydroxyethyl)glycine; CaaD; trans-3-chloroacrylic acid dehalogenase; cis-CaaD; cis-3-chloroacrylic acid dehalogenase; ESI-MS; electrospray ionization mass spectrometry; LB; Luria-Bertani; 4-OT; 4-oxalocrotonate tautomeras

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Solution structure of subunit F (Vma7p) of the eukaryotic V1VO ATPase from Saccharomyces cerevisiae derived from SAXS and NMR spectroscopy

Keywords: DSS; 2, 2-dimethyl-2-silapentane-5-sulphonate; NMR; nuclear magnetic resonance; NOE; nuclear Overhauser effect; NOESY; NOE spectroscopy; NMRSD; normalized root mean square deviation; RMSD; root mean square distance; Vacuolar ATPase; V1VO ATPase; V1 ATPase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization

Keywords: (S)-ASA; (S)-aspartate-semialdehyde; DHDPR; dihydrodipicolinate reductase; DHDPS; dihydrodipicolinate synthase; HTPA; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid; NAL; neuraminidate lyase; rmsd; root-mean-square deviation; Dihydrodipicolinate

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G⁎ apolipoprotein J peptide using solution NMR

Keywords: ApoA-I; apolipoprotein A-I; CSI; chemical shift index; DPC; dodecyphosphocholine; DSS; sodium 2,2-dimethyl-2-silapentane-5-sulfonate; KOdiA-PC; 1-palmitoyl-2-(5-keto-6-octene dioyl)phosphatidylcholine; NMR; nuclear magnetic resonance; NOE; nuclear Overhau

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Unexpected wide substrate specificity of C. perfringens α-toxin phospholipase C

Keywords: Ala and A; alanine; Asp and D; aspartic acid; BcPLC; Bacillus cereus phospholipase C; BSA; bovine serum albumin; CbPLC; Clostridium bifermentans phospholipase C; CDCl3-d; deuterated chloroform; Chol; cholesterol; CpPLC; Clostridium perfringens phospholipa

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The 1.9 Å crystal structure of Prp20p from Saccharomyces cerevisiae and its binding properties to Gsp1p and histones

Keywords: RCC1; regulator of chromosome condensation 1; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; NLS; nuclear localization signal; RLD; RCC1-like domain; MD; molecular dynamics; NPC; nuclear pore complex; BA; boundary activity; GST;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Halogen-substituted (C-β-d-glucopyranosyl)-hydroquinone regioisomers: Synthesis, enzymatic evaluation and their binding to glycogen phosphorylase

Keywords: Type 2 diabetes; Glycogen phosphorylase; C-glucosyl aryl; C-glucopyranosyl hydroquinone; Inhibition; X-ray crystallography; GP; glycogen phosphorylase; GPb; rabbit muscle glycogen phosphorylase b; PLP; pyridoxal 5′-phosphate; Glc-1-P; α-d-glucose 1-pho

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization

Keywords: Bupivacaine; Cardiotoxicity; Electrophysiology; hERG channel; Molecular docking; Stereoselectivity; AP; action potential; cLQTS; congenital long QT syndrome; diLQTS; drug-induced long QT syndrome; ECG; electrocardiogram; ES; extracellular solution; GB/SA;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Molecular docking and pharmacogenomics of Vinca alkaloids and their monomeric precursors, vindoline and catharanthine

Keywords: ABC transporter; ATP-binding cassette transporter; HNSCC; head and neck squamous cell carcinoma; IC50; 50% inhibition concentration; RMSD; root mean square deviations; mRNA; messenger RNA; NCI; national cancer institute; Centrosomal clustering; Molecular

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

Keywords: Aminoacyl-tRNA synthetase; Protozoa; Drug target; Leishmaniasis; Trypanosomiasis; Enzyme product complex; aaRS; aminoacyl-tRNA synthetase; AQP; adenosine-5′-tetraphosphate; CP1; connective peptide insertion 1; CP2; connective peptide insertion 2; AspRS;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity

Keywords: Allergy; cross-reactivity; x-ray structures; IgE binding; epitope prediction; allergen surfaces; hypoallergenic derivatives; allergen-specific immunotherapy; bBLG; Bovine β-lactoglobulin; CR; Cross-reactivity; LLPR; Pathogenesis-related Lupinus luteus pr

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه