کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2581360 | 1130187 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative damage to proteins and DNA in rats exposed to cadmium and/or ethanol
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کلمات کلیدی
GPXNP-SHOxidative protein damageMDA–SH8-OHdGT-SHGSTGSHEtOHCAT8-hydroxy-2′-deoxyguanosine - 8-هیدروکسی-2'-دگزسی گوانوزینPSH - PAROS - ROSOxidative DNA damage - آسیب اکسیداتیو DNAEthanol - اتانولHER - اوOxidative stress - تنش اکسیداتیوSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازmalondialdehyde - مالون دی آلدهیدMetallothionein - متالوتونیئینVitamin E - ویتامین E vitamin C - ویتامین سیCatalase - کاتالازCadmium - کادمیمreduced glutathione - کاهش گلوتاتیونThiol groups - گروه های تیولglutathione S-transferase - گلوتاتیون S-ترانسفرازglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The study was aimed to estimate whether rat's exposure to cadmium (Cd; 50Â mg/l in drinking water for 12 weeks) and/or ethanol (EtOH; 5Â g/kg b.wt./24Â h p.o. for 12 weeks), noted by us to induce oxidative stress and stimulate lipid peroxidation, can cause oxidative damage to proteins and DNA, and whether and to what extent the effects of co-exposure differ from those observed under the treatment with each substance alone. Protein carbonyl groups (PC) and protein thiol groups (PSH) in the serum, liver and kidney, as markers of oxidative protein damage, and 8-hydroxy-2â²-deoxyguanosine (8-OHdG) in the serum, as a marker of DNA oxidation, were determined. The exposure to Cd or/and EtOH led to oxidative protein damage (increased PC and decreased PSH concentrations in the serum and/or liver), and to DNA oxidation (increased 8-OHdG concentration in the serum). The effects were more advanced at the co-exposure than at the treatment with each substance alone. The more serious damage to proteins and DNA at the co-exposure to Cd and EtOH seems to be the effect of independent action of both xenobiotics. The results of the present paper together with our recent findings in the same rats seem to indicate that at co-exposure to Cd and EtOH proteins and DNA may be more vulnerable to oxidation than lipids. The paper is the first report suggesting that excessive EtOH consumption during exposure to Cd may increase the risk of health damage via enhancing protein and DNA oxidation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 180, Issue 1, 15 June 2009, Pages 31-38
Journal: Chemico-Biological Interactions - Volume 180, Issue 1, 15 June 2009, Pages 31-38
نویسندگان
MaÅgorzata GaÅażyn-Sidorczuk, MaÅgorzata M. Brzóska, Maria Jurczuk, Janina Moniuszko-Jakoniuk,