Evaluation of the wound healing activity of Shorea robusta, an Indian ethnomedicine, and its isolated constituent(s) in topical formulation

The topical application of extract(s) of Shorea robusta young leaves, and its isolated compounds ursolic acid and bergenin may promote wound healing activity in Excision Incision and Dead space wound models in rats, probably by inhibiting or modulating some mediators and inflammatory cytokines like TNF-α and PGE2. The tissue histology of wounded and treated (extracts or compounds) animals showed complete epithelialisation with increased collagenation. Hence this study provides the pharmacological evidence of the folk use of Shorea robusta young leaves, for wound healing.198