کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8634103 | 1569090 | 2018 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Randomization to 6-month Mediterranean diet compared with a low-fat diet leads to improvement in Dietary Inflammatory Index scores in patients with coronary heart disease: the AUSMED Heart Trial
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کلمات کلیدی
IQRCHDMUFAEVOOMVPAANCOVAAmI - AMIDiI - DIIRandomized controlled trial - آزمایش تصادفی کنترل شدهConsolidated Standards of Reporting Trials - استانداردهای تلفیقی گزارش های تحقیقاتیPolyunsaturated fatty acids - اسید چرب اشباع نشدهPUFA - اسید چرب چند غیراشباعmonounsaturated fatty acids - اسیدهای چرب غیر اشباعstandard deviation - انحراف معیارinterleukin - اینترلوکینRetinol equivalents - برابرین رتینولcoronary heart disease - بیماری عروق کرونر قلبCoronary disease - بیماری های عروق کرونریanalysis of covariance - تجزیه و تحلیل کوواریانسELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاtumor necrosis factor-α - تومور نکروز عامل αhigh sensitivity - حساسیت بالاExtra virgin olive oil - روغن زیتون اضافیMediterranean diet - رژیم غذایی مدیترانهایAcute myocardial infarction - سکته قلبیDietary inflammatory index - شاخص التهاب رژیم غذاییconfidence interval - فاصله اطمینانTNF-α - فاکتور نکروز توموری آلفاModerate-to-vigorous physical activity - فعالیت بدنی متوسط تا شدیدinterquartile range - محدوده بین محدبC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی MedDiet - پیچ و تابCONSORT - کنسول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
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چکیده انگلیسی
A higher dietary inflammatory index (DII®) score is associated with inflammation and incidence of coronary heart disease (CHD). We hypothesized that a Mediterranean diet (MedDiet) intervention would reduce DII score. We assessed dietary data from a randomized controlled trial comparing 6-month MedDiet versus low-fat diet intervention, in patients with CHD. We aimed to determine the DII scores of the prescribed diets' model meal plans, followed by whether dietary intervention led to lower (i.e., more anti-inflammatory) DII scores and consequently lower high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (hs-IL-6). DII scores were calculated from 7-day food diaries. The MedDiet meal plan had a markedly lower DII score than the low-fat diet meal plan (â4.55 vs. -0.33, respectively). In 56 participants who completed the trial (84% male, mean age 62â¯Â±â¯9 years), the MedDiet group significantly reduced DII scores at 6 months (nâ¯=â¯27; â0.40â¯Â±â¯3.14 to â1.74â¯Â±â¯2.81, Pâ¯=â¯.008) and the low-fat diet group did not change (nâ¯=â¯29; â0.17â¯Â±â¯2.27 to 0.05â¯Â±â¯1.89, Pâ¯=â¯.65). There was a significant post-intervention adjusted difference in DII score between groups (compared to low-fat, MedDiet decreased by â1.69 DII points; Pâ¯=â¯.004). When compared to the low-fat diet, the MedDiet non-significantly reduced hs-IL-6 (â0.32 pg/mL, Pâ¯=â¯.29) and increased hs-CRP (+0.09 mg/L, Pâ¯=â¯.84). These findings demonstrated that MedDiet intervention significantly reduced DII scores compared to a low-fat diet. However, in this small cohort of patients with CHD this did not translate to a significant improvement in measured inflammatory markers. The effect of improvement in DII with MedDiet should be tested in larger intervention trials and observational cohorts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 55, July 2018, Pages 94-107
Journal: Nutrition Research - Volume 55, July 2018, Pages 94-107
نویسندگان
Hannah L Mayr, Colleen J Thomas, Audrey C Tierney, Teagan Kucianski, Elena S George, Miguel Ruiz-Canela, James R Hebert, Nitin Shivappa, Catherine Itsiopoulos,