Inflammasomes as molecular mediators of inflammation and cancer: Potential role in melanoma
Keywords: Inflammasome; Inflammation; Cancer; Melanoma; IL-1β; ASC;
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Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat
Keywords: ANOVA; one-way analysis of variance; AUC; area under the curve; ELISA; enzyme-linked immunosorbent assay; IL-1β; interleukin-1β; MFW; mean frequency of withdrawal; PWF; paw withdrawal frequency; PWT; paw withdrawal threshold; TNF-α; tumor necrosis fact
Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages
Keywords: ATP; adenosine tri-phosphate; BPI-sf; brief pain inventory short form; CNS; central nervous system; GFAP; glial fibrillary acidic protein; GM-CSF; granulocyte macrophage colony stimulating factor; Iba-1; ionized calcium binding adaptor molecule 1; IC50; i
Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome
Keywords: Schizophrenia; Metabolic syndrome; Cytokines; Adipokines; Chemokines; Diabetes; CCL2; CCL4; IL-1β; TNF-α; IL-6; PTX3; Leptin; Adiponectin; PAI-1; OPG; ICAM-1; Monocytes; Macrophages;
A self-propelling cycle mediated by reactive oxide species and nitric oxide exists in LPS-activated microglia
Keywords: CAT; catalase; CNS; central nervous system; DCFH-DA; 2â²7â²-dichlorodihydrofluororescein diacetate; DMSO; dimethylsulfoxide; DPI; diphenyleneiodonium sulfate; FBS; fetal bovine serum; HBSS; Hank's balanced salt solution; IFN-γ; interferon-γ; IL-1β;
IL1β-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells
Keywords: IL-1β; Interleukin 1-β; COX; Cyclooxygenase; PGE2; Prostaglandin E2; PKC; Protein kinase C; NS 398; N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide; STA; Staurosporine; BIM.; Bisindoylmalemide I; Colonic fibroblasts; Cyclooxygenase-2; Prostaglandi
A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells
Keywords: AD; Alzheimer's disease; bFGF; basic fibroblast growth factor; BrdU; 5â²-bromo-deoxyuridine; DG; dentate gyrus; DIV; days in vitro; DCX; doublecortin; DMEM; Dulbecco's modified eagle's medium; E; embryonic age; EGF; epidermal growth factor; GAPDH; glycer
Atlantic halibut experimentally infected with nodavirus shows increased levels of T-cell marker and IFNγ transcripts
Keywords: T-cell receptor; TCRβ; CD4; CD4-2; CD8α; CD8β; Lck; ZAP-70; Interleukin; IL-1β; IL-6; IL-11; IL-12β; IFNγ; Toll like receptor; TLR7; ISG15; Mx; Teleost; Fish; NNV; AHNV; VER; Concanavalin A; PMA; ConA; Imiquimod;
The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity
Keywords: Microbiota; Stress; Social disruption; Macrophage; Microbicidal activity; Peroxynitrite; IL-1β; TNF-α; iNOS; Superoxide; Peptidoglycan;
Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby “six-mix” amphiboles and subsequent activation of BEAS-2B cells
Keywords: Chrysotile asbestos; Libby six-mix amphiboles; Macrophage; IL-1β; Epithelium; ASC; apoptosis-associated speck-like protein containing a CARD; Chry; chrysotile; Cot; cancer osaka thyroid oncogene; DNPH; 2,4-dinitrophenylhydrazine; EMSA; electrophoretic mo
CNS response to a second pro-inflammatory event depends on whether the primary demyelinating lesion is active or resolved
Keywords: Cytokines; Inflammation; Demyelination; Microglia; Relapse; IL-1β; IL-1R1;
Aging and infection reduce expression of specific brain-derived neurotrophic factor mRNAs in hippocampus
Keywords: Aging; Inflammation; Interleukin-1; IL-1β; LTP; Learning; Memory; Hippocampus; Infection; BDNF mRNA; Long 3ⲠUTR; Exons; Transcripts; Cytokines; Lipopolysaccharide; Dendrites;
Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells
Keywords: 2VO; bilateral occlusion of the common carotid arteries; APP; β-amyloid precursor protein; CNTF; ciliary neurotrophic factor; CTB; cholera toxin β-subunit; IL-1β; interleukin-1β; IL-6; interleukin-6; IOP; intraocular pressure; LPS; lipopolysaccharide;
The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β
Keywords: Alzheimer's disease; Anesthesia; Isoflurane; TNF-α; IL-6; IL-1β;
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
Keywords: Nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome; particulate matter with mean diameter less than 10 μm; IL-1β; mouse; human; oxidative stress; dendritic cell; BAL; Bronchoalveolar lavage; BEGM; Bronchial epithelial growth medium
Electrical stimulation ameliorates light-induced photoreceptor degeneration in vitro via suppressing the proinflammatory effect of microglia and enhancing the neurotrophic potential of Müller cells
Keywords: ES; electrical stimulation; TCES; transcorneal electrical stimulation; TRES; transretinal electrical stimulation; IL-1β; interleukin-1β; TNF-α; tumor necrosis factor-α; BDNF; brain-derived neurotrophic Factor; CNTF; ciliary neurotrophic factor; RP; re
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
Keywords: CRB; cerebellum; CTX; cerebral cortex; DA; dopaminergic; IBA-1; ionized calcium binding adaptor molecule 1; IL-1β; interleukin-1 beta; IP; intraperitoneal; ND; not determined; PBS; phosphate buffered saline; PFA; paraformaldehdye; PD; Parkinson's disease
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways
Keywords: Toll-like receptor 8; innate immunity; neonate; newborn; alum; adjuvant; adenosine; IL-1β; caspase-1; inflammasome; APC; Antigen-presenting cell; cAMP; Cyclic adenosine monophosphate; CBMC; Cord blood mononuclear cell; db-cAMP; Dibutyryl-cAMP; DC; Dendri
Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice
Keywords: β-Lapachone; Lecithin-chitosan nanoparticles; Cutaneous leishmaniasis; Topical treatment; IL-1β; Cyclooxygenase-2;
Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms
Keywords: NALP3; Cryopyrin; CIAS1; ASC; TUCAN; IL-1β; NOD2;
Involvement of glutamate NMDA and AMPA receptors, glial cells and IL-1β in the spinal hyperalgesia evoked by the chemokine CCL2 in mice
Keywords: CCL2; Spinal cord; Thermal hyperalgesia; AMPA; NMDA; Microglia; Astroglia; IL-1β;
Systemic inflammation enhances surgery-induced cognitive dysfunction in mice
Keywords: Neuroinflammation; Hippocampus; Memory; Fear conditioning; IL-1β; LPS; Surgery; POCD;
Plant flavonol quercetin and isoflavone biochanin A differentially induce protection against oxidative stress and inflammation in ARPE-19 cells
Keywords: AMD; age-related macular degeneration; ARE; antioxidant response element; COX-2; cyclooxygenase-2; GST; glutathione S-transferase; HO-1; heme oxygenase-1; IL-1β; interleukin-1β; IL-6; interleukin-6; iNOS; inducible nitric oxide synthase; NF-κB; nuclear
COX-2 regulates the proliferation of glioma stem like cells
Keywords: Glioblastoma; COX-2; IL-1β; p53;
Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats
Keywords: Adjuvant arthritis; Elevated plus-maze; Hippocampus; NOX1; iNOS; IL-1β; IL-6;
Intracellular calcium level is upregulated by interleukin-32 in auditory cells
Keywords: BAPTA-AM; 1, 2-bis (2-aminophenoxy) ethane-N, N, N', N'-tetraacetic acid acetoxymethyl ester; FBS; fetal bovine serum; MTT; 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyl- tetrazolium bromide; PBS; phosphate-buffered saline; PBST; PBS containing 0.05% Twe
Mathematical relationship between cytokine concentrations and pathogen levels during infection
Keywords: CFU; colony forming unit; TNFα; tumor necrosis factor; IFNγ; interferon γ; MCP-1; monocyte chemotactic protein 1; IL-1β; interleukin-1β; IL-18; interleukin-18; Cytokine; Pathogen level; Bacterial infection; Bioinformatics analysis;
Short communicationThe effects of age on lipopolysaccharide-induced cognitive deficits and interleukin-1β expression
Keywords: LPS; Shuttlebox; Cytokines; Aging; Memory Consolidation; IL-1β;
TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation
Keywords: IL-1β; TAK1; Lys63-linked polyubiquitination; Lysine 158;
Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
Keywords: PG; prostaglandin; cPGES; cytosolic PGE synthase; 15-PGDH; 15-hydroxyprostaglandin dehydrogenase; mPGES; membrane-bound PGE synthase; COX; cyclooxygenase; PLA2; phospholipase A2; IL-1β; interleukin-1β; Prostaglandin E2; Cytosolic prostaglandin E synthas
Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats
Keywords: Cell injury; Cognitive functions; Cytokines; Isoflurane; Rats; Aβ; β-amyloid peptide; AD; Alzheimer's disease; IL-1β; interleukin-1β; MAC; minimum alveolar concentrations; POCD; post-operative cognitive dysfunction; SpO2; pulse oximeter oxygen satur
Association of statins with inflammatory cytokines: A population-based Colaus study
Keywords: IL-1β; IL-6; TNF-α; CRP; Population study; Statins; Cytokines;
Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1β and inhibited by growth hormone releasing hormone and somatostatin
Keywords: Pituitary cells (human somatotroph adenoma cells); IL-1β; IL-6; IL-8; GH;
Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats
Keywords: ALI; acute lung injury; ARDS; acute respiratory distress syndrome; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor; IL-1β; interleukin-1β; IL-1ra; receptor antagonists to IL-1; LXRs; liver X receptors; RXR; retinoid X receptor; iNOS; inducible ni
Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model
Keywords: DE; extract of dioscorea; DMBA; 7,12-dimethyl-1,2-benz[a]anthracene; DTT; dithiothreitol; HBP; hamster buccal pouch; HMG-CoA; 3-hydroxy-3-methylglutaryl coenzyme A; IL-1β; interleukin-1β; NBT; nitro blue tetrazolium; NO; nitric oxide; OSCC; oral squamou
Anti-atherogenic effect of San-Huang-Xie-Xin-Tang, a traditional Chinese medicine, in cultured human aortic smooth muscle cells
Keywords: SHXXT; San-Huang-Xie-Xin-Tang; HASMC; human aortic smooth muscle cell; LPS; lipopolysaccharides; ROS; reactive oxygen species; MTT; dimethyl-thiazol-diphenyltetrazoliumbromide; IL-1β; interleukin 1β; IL-6; interleukin 6; IL-8; interleukin 8; MCP-1; mono
Research reportCirculating IL-6 contributes to peripheral LPS-induced mPGES-1 expression in the rat brain
Keywords: BBB; blood-brain barrier; BAT; brown adipose tissue; COX2; cyclooxygenase 2; CVOs; circumventricular organs; DAPI; 4â²,6-diamidino-2-phenyl-indole dilactate; eW; epididymal white; IL-1β; interleukin-1 beta; IL-6; interleukin-6; IR; immunoreactivity; L
Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3â²,5â²-cyclic monophosphate formed in glia cells
Keywords: iNOS; inducible nitric oxide synthase; sGC; soluble guanylate cyclase; cGMP; guanosine 3â²,5â²-cyclic monophosphate; 8-nitro-cGMP; 8-nitroguanosine 3â²,5â²-cyclic monophosphate; RNOS; reactive nitrogen oxide species; LC-MS/MS; liquid chromatography-ta
LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb
Keywords: Heat-labile enterotoxin; Mucosal immunology; Adjuvant; IL-1β; IL-17; IFN-γ;
Understanding the mechanism of IL-1β secretion
Keywords: IL-1β; Caspase-1; Inflammation; Golgi; Cell death;
Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease
Keywords: Alzheimer's disease; Cerebral ischemia; Cognitive impairment; IL-1β; TNF-α;
Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide
Keywords: BCA; bicinchoninic acid; BiP; binding immunoglobulin protein; Chop; C/EBP-homologous protein; IFNγ; interferon γ; IL-1β; interleukin-1 β; iNOS; inducible nitric synthase; IRE; inositol requiring ER-tonucleus signal kinase; NFκB; nuclear factor κB; N
Research reportIntracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats
Keywords: ACSF; artificial cerebrospinal fluid; AP5; 2-amino-5-phosphonopentanoic acid; COX-2; cyclooxygenase-2; i.c.v.; intracerebroventricular; IL-1β; interleukin-1β; IL-1R; interleukin-1 receptor; IL-1ra; endogenous antagonist of interleukin-1 receptor; IL-6;
A neuronal transmembrane protein LRFN4 induces monocyte/macrophage migration via actin cytoskeleton reorganization
Keywords: FNIII; fibronectin type III; HUVECs; human umbilical vein endothelial cells; IgC2; immunoglobulin C2-like; IL-1β; interleukin-1β; LRFN; leucine-rich repeat and fibronectin type III domain-containing; LRFN4-CT; LRFN4 cytoplasmic region; LRRs; leucine-ric
Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats
Keywords: Aging; Nutrition; High-fat diet; Skeletal muscle; Protein synthesis; CPT-1b; carnitine palmitoyltransferase-1b; IR; insulin resistance; Il-1β; interleukin-1 beta; mTOR; mammalian target of rapamycin; MCAD; medium-chain acyl-CoA dehydrogenase; MPS; muscle
Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation
Keywords: 26; 29; AAs; aortic aneurysms; AAA; abdominal aortic aneurysm; BMC; bone marrow cell; IL-1β; interleukin-1β; MCP1; monocyte chemotactic protein 1; MMPs; matrix metalloproteinases; qPCR; quantitative polymerase chain reaction; SmαA; smooth muscle α-act
Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement
Keywords: Immunocompetent cells; Initial stage of Orthodontic tooth movement; OX6; ED1; IL-1β; TNF-α; HSP27; Rat;
Topical application of porcine placenta extract inhibits the progression of experimental contact hypersensitivity
Keywords: PE; placenta extract; LPS; lipopolysachharide; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1 beta; IFN-γ; interferon gamma; IL-4; interleukin 4; IL-6; interleukin 6; IL-2; interleukin 2; IL-17; interleukin 17; CHS; contact hypersensitivity;
Douleur et immunité
Keywords: Nocicepteurs; Douleur neuropathique; Allodynie; TLR; IL-1β; TNF-α; Résolvines; Synapse neuro-immune;
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; APMA; p-amino-phenyl-mercuric acetate; anti-ARLEIE; an antibody directed against the ARLEIE sequence within aggrecan; CS-2; chondroitin sulfate-2 region; ECM; extracellular matrix; G1