دانلود مقالات ISI درباره پروتئین پریون + ترجمه فارسی

Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway

Keywords: پروتئین پریون; AMPK; AMP-activated protein kinase; ATG5; autophagy-related 5; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LDH; lactate dehydrogenase; mTOR; mammalian target of rapamycin; PI; propidium iodide; PrP; pr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line

Keywords: پروتئین پریون; AOX1; aldehyde oxidase 1; ARE; antioxidant response element; B2M; β-2-micoglobulin; BDE-47; 2,2′,4,4′-tetra-BDE; BSO; buthionine sulfoximine; CMV; cytomegalovirus; COX-2; cyclooxygenase-2; DHCR24; 24-dehydrocholesterol reductase; DMSO; dimethyl sulfo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Live-cell FRET imaging reveals clustering of the prion protein at the cell surface induced by infectious prions

Keywords: پروتئین پریون; Prion protein; Live-cell FRET imaging; CFP-YFP; m-turquoise2; FLIM; Prion propagation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein

Keywords: پروتئین پریون; PrP; prion protein; PrPC; the normal cellular PrP; FFI; fatal familial insomnia; huPrP; human prion protein; HPLC; high performance liquid chromatography; MS; mass spectrometry; MALDI-TOF; matrix-assisted laser desorption/ionization time-of-flight; LC; li

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Mahogunin ring finger 1 suppresses misfolded polyglutamine aggregation and cytotoxicity

Keywords: پروتئین پریون; AIP4; atrophin-interacting protein 4; Baf; bafilomycin; BMP; bis(monoacylglycero)phosphate; CMA; chaperone-mediated autophagy; CQ; chloroquine; HD; Huntington disease; HECT; homologous to E6-AP C-terminus; IB; inclusion bodies; Lamp2a; lysosome associated

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Recombinant expression of soluble murine prion protein for C-terminal modification

Keywords: پروتئین پریون; ASP; 6xHis-ATPase-SrtA-PrP; ASPM; 6xHis-ATPase-SrtA-PrP-MxeIntein-6xHis-CBD; CBD; chitin binding domain; GPI; glycosylphosphatidylinositol; GSH; reduced glutathione; GSSG; oxidized glutathione; HDP; 6xHis-DnaK-TEV-PrP; IPTG; isopropyl-β-d-thiogalactopyra

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Molecular cloning and sequence analysis of prion protein gene in Xiji donkey in China

Keywords: پروتئین پریون; TSEs; transmissible spongiform encephalopathies; CJD; Creutzfeldt-Jakob disease; vCJD; variant Creutzfeldt-Jakob diseases; BSE; bovine spongiform encephalopathy; CWD; chronic wasting disease; FME; feline spongiform encephalopathy; TME; mink spongiform

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Specific inhibition of hamster prion protein translocation by the dodecadepsipeptide valinomycin

Keywords: پروتئین پریون; Translocation; Signal sequence; Valinomycin; pQC pathway; Prion protein;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Lysine hydroxylation and O-glycosylation in the globular, C-terminal region of mammalian-expressed, recombinant PrP

Keywords: پروتئین پریون; CAD; collisionally activated dissociation; CHO; Chinese hamster ovary; GPI; glycosylphosphatidylinositol; MS; mass spectrometry; MS/MS; tandem mass spectrometry; PRNP; the gene encoding the prion protein; PrPC; cellular prion protein; PrPSc; scrapie isofo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation

Keywords: پروتئین پریون; aa; amino acid; ATP; adenosine triphosphate; β-Gal; β-Galactosidase; (Cherry)2; tandem Cherry dimer; (Cherry)4; tandem Cherry tetramer; CNS; central nervous system; DEG; 2-deoxy-d-glucose; DMEM; High-glucose Dulbecco's Modified Eagle medium; ECL; enhanc

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Differential molecular chaperone response associated with various mouse adapted scrapie strains

Keywords: پروتئین پریون; Amyloid; Heat shock proteins; Glucose-regulated proteins; Prion protein; Prion strains;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein

Keywords: پروتئین پریون; Amyloidogenic protein; Gold nanoparticle; Prion protein; Label-free detection;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Development and applications of simultaneous immunochemical staining and serial detection of overlapping proteins in blotting procedures

Keywords: پروتئین پریون; Immunoblot; Characterization; Duplex staining; Prion protein; Protein typing;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Blood storage affects the detection of cellular prion protein on peripheral blood leukocytes and circulating dendritic cells in part by promoting platelet satellitism

Keywords: پروتئین پریون; Flow cytometry; Prion protein; Blood storage; Leukocytes; Platelet satellitism;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mixed metal copper(II)-nickel(II) and copper(II)-zinc(II) complexes of multihistidine peptide fragments of human prion protein

Keywords: پروتئین پریون; Prion protein; Peptides; Copper(II); Nickel(II); Zinc(II); Stability constants;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Prolongation of prion disease-associated symptomatic phase relates to CD3+ T cell recruitment into the CNS in murine scrapie-infected mice

Keywords: پروتئین پریون; PrPc; cellular prion protein; PrPSc; prion protein scrapie; rAd; recombinant adenovirus; TSE; transmissible spongiform encephalopathy; AA; amino acid; Wt; wild-type; CTL; cytotoxic T lymphocytes; CNS; central nervous system; OligoCpG; oligodeoxy nucleotid

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Cytosolic prion protein is the predominant anti-Bax prion protein form: Exclusion of transmembrane and secreted prion protein forms in the anti-Bax function

Keywords: پروتئین پریون; PrP; prion protein; Bax; Bcl-2 associated protein X; SHaPrP; Syrian hamster prion protein; EGFP; enhanced green fluorescence protein; EGFP-Bax; N-terminally EGFP-tagged-Bax; CyPrP; cytosolic prion protein; GPI; glycosylphosphatidylinositol; SP-CyPrP; sign

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Toward understanding Machado-Joseph disease

Keywords: پروتئین پریون; ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular cloning and polymorphism analysis of the prion protein gene in Tan sheep of Ningxia, China

Keywords: پروتئین پریون; TSE; transmissible spongiform encephalopathies; CJD; Creutzfeldt-Jakob disease; BSE; bovine spongiform encephalopathy; PrP; prion protein; PrPc; cellular prion protein; PRNP; prion protein gene; SNPs; single nucleotide polymorphisms; ARQ; A136R154Q171;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

CdTe quantum dots as a highly selective probe for prion protein detection: Colorimetric qualitative, semi-quantitative and quantitative detection

Keywords: پروتئین پریون; CdTe quantum dots; Prion protein; Fluorescent probe; Protein aggregation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Alteration of the endocannabinoid system in mouse brain during prion disease

Keywords: پروتئین پریون; prion; endocannabinoid; cannabinoid receptor; neurodegenerative disease; brain; mouse; AEA; arachidonoylethanolamide or anandamide; CBD; cannabidiol; CBR; cannabinoid receptor; CJD; Creutzfeldt-Jakob disease; GAPDH; glyceraldehyde-3-phosphate dehydrogenas

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Conversion of bacterially expressed recombinant prion protein

Keywords: پروتئین پریون; PrP; prion protein; rPrP; recombinant mouse PrP; rPrP-res; the proteinase K-resistant recombinant PrP form that is associated with prion infectivity; PMCA; Protein Misfolding Cyclic Amplification; Prion; Recombinant protein; In vitro conversion; Infectivi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide

Keywords: پروتئین پریون; Prion protein; Mutant PrP; Cellular assay;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cells

Keywords: پروتئین پریون; Aβ; β-amyloid; AD; Alzheimer's disease; ΔΨm; mitochondrial transmembrane potential; FBS; fetal bovine serum; H. pylori; Helicobacter pylori; HRC; histidine-rich Ca2+ binding protein; IAPP; islet amyloid polypeptide; JC-1; 5,5′,6,6′-tetrachloro-1,1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Tau inhibits tubulin oligomerization induced by prion protein

Keywords: پروتئین پریون; AD; Alzheimer disease; CBB; Coomassie brilliant blue; CtmPrP; transmembrane form of prion protein with the C-terminus residing in the lumen of endoplasmic reticulum; cytoPrP; cytosolic prion protein; EDC; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; ER;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Atlas of transgenic Tet-Off Ca2+/calmodulin-dependent protein kinase II and prion protein promoter activity in the mouse brain

Keywords: پروتئین پریون; Digital brain atlas; Neuroinformatics; Inducible models; Tetracycline-responsive; Ca2+/calmodulin-dependent protein kinase II; Prion protein;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses

Keywords: پروتئین پریون; AD; Alzheimer's disease; PD; Parkinson's disease; Aβ; beta-amyloid peptide; PrP; prion protein; scFv; single chain variable fragment; ThT; thioflavin T; ThS; thioflavin S; TEM; Transmission Electron Microscope; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphe

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

RNA granules: The good, the bad and the ugly

Keywords: پروتئین پریون; ATXN2; Ataxin-2; BicD; Bicaudal D; CBP; CREB Binding Protein; CPEB; Cytoplasmic Polyadenylation Element Binding protein; DHC; Dynein Heavy Chain; DIC; Dynein Intermediate Chain; FAK; Focal Adhesion Kinase; FUS/TLS/hnRNP P2; Fused in Sarcoma; G3BP; Ras-GAP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

Keywords: پروتئین پریون; Prion protein; hPrP90-231 wt; E200K and D202N mutations; Neurotoxicity; Familial TSE;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion

Keywords: پروتئین پریون; Prion protein; PrP; Nucleic acids; Glycosaminoglycans; Transmissible spongiform; Encephalopathy; Neurodegenerative diseases; PrP partners; PrP structure; PrP conversion;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Cellular prion protein overexpression disturbs cellular homeostasis in SH-SY5Y neuroblastoma cells but does not alter p53 expression: a proteomic study

Keywords: پروتئین پریون; prion protein; signal transduction; cytoskeleton; protein folding; annexin V; transgelin 2; ADHX; alcohol dehydrogenase class III; ANXA5; annexin V; CV028; UPF0027 protein; DMEM; Dulbecco's modified Eagle medium; FCS; fetal calf serum; FKBP4; FK506-bindin

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

Keywords: پروتئین پریون; PD; Parkinson's Disease; αS; α-synuclein; UPS; ubiquitin-proteasome system; PrP; prion protein; WT; wild-type; CTL; control; CT; chymotrypsin; T; trypsin; C; caspase; SEC; size exclusion chromatography; HMW; high molecular weight; LMW; low molecular w

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

Intracellular Ca2+ storage in health and disease: A dynamic equilibrium

Keywords: پروتئین پریون; Aβ; amyloid-β; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; APP; amyloid precursor protein; Bax; Bcl-2-associated Xprotein; BI-1; Bax Inhibitor-1; [Ca2+]cyt; cytosolic Ca2+ concentration; [Ca2+]ER; endoplasmic-reticulum

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2010 سفارش ترجمه

Establishment of an SV40 large T antigen-immortalized bovine brain cell line and its neuronal differentiation by dibutyryl-cyclic AMP

Keywords: پروتئین پریون; Bovine brain cell line; Immortalization; Neuronal differentiation; Prion protein;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro

Keywords: پروتئین پریون; Transmissible spongiform encephalopathy; Prion; Prion protein; Conformational conversion; Glycophosphatidylinositol anchor; GPI; glycophosphatidylinositol; NBH; normal hamster brain homogenate; PI-PLC; phosphatidylinositol-specific phospholipase C; PK; pr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

α-cleavage of the prion protein occurs in a late compartment of the secretory pathway and is independent of lipid rafts

Keywords: پروتئین پریون; ADAM; a disintegrin and metalloprotease; Endo H; Endoglycosidase H; ER; endoplasmic reticulum; GPI; glycosyl-phosphatidylinositol; PBS; phosphate-buffered saline; PNGase F; peptide N-glycosidase F; PrPC; cellular form of prion protein; PrPSc; infectious,

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Donut-shaped fingerprint in homologous polypeptide relationships-A topological feature related to pathogenic structural changes in conformational disease

Keywords: پروتئین پریون; Homologous relationship; Polypeptide; Prion protein; Conformational disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Acetylcholinesterase as an amyloid enhancing factor in PrP82-146 aggregation process

Keywords: پروتئین پریون; Acetylcholinesterase; AChE peripheral site; AChE peripheral site blockers; Amyloid aggregation process; Prion protein; Gerstmann-Sträussler-Scheinker disease; PrP82-146;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Thr but Asn of the N-glycosylation sites of PrP is indispensable for its misfolding

Keywords: پروتئین پریون; Prion protein; N-linked glycosylation; Conversion; Site-directed mutagenesis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Prion early kinetics revisited using a streptomycin-based PrPres extraction method

Keywords: پروتئین پریون; Infection kinetics; Mouse; Prion protein; Prion spread; Scrapie; Spleen; Streptomycin; Western blot; Preclinical detection;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Instability of familial spongiform encephalopathy-related prion mutants

Keywords: پروتئین پریون; Prion protein; SDSL; ESR; Salt bridge; pH-sensitivity; D178N; Conformational stability; Histidine residue; Familial spongiform encephalopathy; Conformational transition;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

Keywords: پروتئین پریون; AASA; aminoadipic semialdehyde; BSE; bovine spongiform encephalopathy; CEL; N-ɛ-carboxyethyllysine; CJD; Creutzfeldt-Jakob disease; CML; N-ɛ-carboxymethyllysine; DBI; double bond index; GSA; glutamic semialdehyde, 4-HNE, 4-hydroxynonenal; MCO; metal-cat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

The N-terminus of PrP is responsible for interacting with tubulin and fCJD related PrP mutants possess stronger inhibitive effect on microtubule assembly in vitro

Keywords: پروتئین پریون; Prion protein; Tubulin; Molecular interaction; Microtubule dynamics; Transmissible spongiform encephalopathies;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

CRBL cells: Establishment, characterization and susceptibility to prion infection

Keywords: پروتئین پریون; PrP; prion protein; PrPC; cellular prion protein; PrPSc; scrapie prion protein disease; CJD; Creutzfeldt-Jakob; p53−/−; p53 null; CRBL; a cell line established from the cerebellum; N2a; Neuro2a; ScN2a; scrapie-infected N2a; SMB; scrapie-infected mouse

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

In vivo gene delivery for development of mammalian models for Parkinson's disease

Keywords: پروتئین پریون; 6-OHDA; 6-hydroxydopamine; AAV; adeno-associated virus; Ad; adenovirus; CsCl; cesium chloride; DA; dopamine; DAT; dopamine transporter; LRRK2; leucine-rich repeat kinase-2; LV; lentivirus; MFB; medial forebrain bundle; MPTP; N-methyl-4-phenyl-1,2,3,6-tetr

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides

Keywords: پروتئین پریون; PrP; prion protein; PrPC; “cellular” isoform; PrPSc; “scrapie” isoform; TFE; trifluoroethanol; PBS; phosphate buffer solution; TFE/PBS; 87/13 (v/v) TFE/PBS mixture; CD; circular dichroism; NMR; nuclear magnetic resonance; CSD; chemical shift diffe

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

The neuronal ubiquitin-proteasome system: Murine models and their neurological phenotype

Keywords: پروتئین پریون; Aβ; amyloid-β; AD; Alzheimer's disease; AR-JP; Autosomal Recessive-Juvenile Parkinsonism; AS; Angelman syndrome; CHIP; C-terminal Hsp70 interacting protein; DA; dopamine; DUB; deubiquitinating enzyme; ERAD; endoplasmatic reticulum (ER-) associated degra

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2008 سفارش ترجمه

The ubiquitin-proteasome system in spongiform degenerative disorders

Keywords: پروتئین پریون; AD; Alzheimer's disease; AgRP; Agouti related protein; AIDS; acquired immune deficiency syndrome; APP; amyloid precursor protein; ASPA; aspartoacylase gene; Atrn; attractin; BSE; bovine spongiform encephalopathy; CD; Canavan's spongiform leukodystroph

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2008 سفارش ترجمه

A comparative molecular dynamics study on thermostability of human and chicken prion proteins

Keywords: پروتئین پریون; Prion protein; Molecular dynamics simulation; Salt bridge; Unfolding; Ensemble;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Quantitative profiling of the pathological prion protein allotypes in bank voles by liquid chromatography-mass spectrometry

Keywords: پروتئین پریون; Prion protein; Quantitative method; Mass spectrometry;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه