Keywords: پردردی یا هایپرآلژزی; Cast immobilization; Hyperalgesia; Joint limitation; Muscle atrophy; Exercise;
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Keywords: پردردی یا هایپرآلژزی; ANOVA; analysis of variance; CPP; conditioned place preference; escape-avoidance; inflammation; carrageenan; hyperalgesia; analgesia; pain;
Keywords: پردردی یا هایپرآلژزی; Optical imaging; Long-term potentiation (LTP); Glia; Emotion; Hyperalgesia;
Keywords: پردردی یا هایپرآلژزی; Cutaneous leishmaniasis; Cytokines; Hyperalgesia; Hypoalgesia; Intradermal ear infection;
Keywords: پردردی یا هایپرآلژزی; Osteoarthritis; Pain; Hyperalgesia; Allodynia; Spinal cord; Monoiodoacetate;
Keywords: پردردی یا هایپرآلژزی; Substance P; NK1 receptor; Hyperalgesia; Inflammatory pain; Neuropathic pain; Trigeminal nerve;
Keywords: پردردی یا هایپرآلژزی; Agmatine; Allodynia; Hyperalgesia; Neuropathic pain; Sigma Receptor; Hippocampus; TNF-α;
Keywords: پردردی یا هایپرآلژزی; Sleep deprivation; Hyperalgesia; Quantitative sensory testing; Descending pain control; Fibromyalgia syndrome; Central sensitization;
Keywords: پردردی یا هایپرآلژزی; ADMX; adrenomedullectomy; ODN-AS; oligodeoxynucleotide antisense; ODN-MM; oligodeoxynucleotide mismatch; PKCε; protein kinase C epsilon; SEM; standard error of the mean; SS; sound stress; hyperalgesia; nociceptor; painful peripheral neuropathy; alcohol n
Keywords: پردردی یا هایپرآلژزی; Osteoarthritis; Exercise induced analgesia; Exercise; Hyperalgesia; Pressure pain thresholds; Pressure algometry;
Keywords: پردردی یا هایپرآلژزی; Postoperative pain; Hyperalgesia; Glial cell activation; Latent pain sensitization; Naloxone;
Keywords: پردردی یا هایپرآلژزی; AEA; anandamide; CB1R; cannabinoid type-1 receptor; DRG; dorsal root ganglion; FAAH; fatty acid amide hydrolase; FABP; fatty acid binding protein; i.pl; intraplantar; MβC; methyl-β-cyclodextrin; PPARα; peroxisome proliferator-activated receptor alpha;
Keywords: پردردی یا هایپرآلژزی; Allodynia; Hyperalgesia; 5-HT2 receptors; Long-lasting pain
Keywords: پردردی یا هایپرآلژزی; Dry eye symptoms; neuropathic pain; neuropathic ocular pain; allodynia; hyperalgesia; chronic pain; chronic overlapping pain syndromes; central pain syndromes; comorbid pain syndromes
Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice
Keywords: پردردی یا هایپرآلژزی; PLGA; Poly(lactide-coglycolide); DRG compression; Bupivacaine; Nanoparticles; Allodynia; Hyperalgesia;
Morphine antinociception on thermal sensitivity and place conditioning in male and female rats treated with intraplantar complete freund's adjuvant
Keywords: پردردی یا هایپرآلژزی; Conditioned place preference; Hargreaves; Sex difference; Hyperalgesia; Chronic pain; Opioid;
Light emitting diode (LED) therapy reduces local pathological changes induced by Bothrops asper snake venom
Keywords: پردردی یا هایپرآلژزی; Bothrops asper venom; Edema; Hyperalgesia; Light emitting diode; LED therapy myonecrosis;
Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2
Keywords: پردردی یا هایپرآلژزی; Rheumatoid arthritis; Bioavailability; Lipophilicity; PGE2; Thromboxane A; Hyperalgesia; Osteoarthritic pain;
α- (phenylselanyl) acetophenone mitigates reserpine-induced pain-depression dyad: Behavioral, biochemical and molecular docking evidences
Keywords: پردردی یا هایپرآلژزی; Antidepressant; Hyperalgesia; Selenium; Reserpine; Organoselenium; Antioxidant;
Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system
Keywords: پردردی یا هایپرآلژزی; RTQDSXADNWJYMI-UHFFFAOYSA-M; 5-HT; D2; α1; Allodynia; Docking; Forced swim test; Four-plate test; Hyperalgesia; MES; Piperazine derivatives;
Peripheral Synthesis of an Atypical Protein Kinase C Mediates the Enhancement of Excitability and the Development of Mechanical Hyperalgesia Produced by Nerve Growth Factor
Keywords: پردردی یا هایپرآلژزی; APs; action potentials; CFA; complete Freund's adjuvant; DRG; dorsal root ganglion; HPRT; hypoxanthineguanine phosphoribosyltransferase; LTP; long-term potentiation; MPE; maximal possible effect; mPSI; myristoylated pseudosubstrate inhibitor of atypical
Sustained stimulation of β2- and β3-adrenergic receptors leads to persistent functional pain and neuroinflammation
Keywords: پردردی یا هایپرآلژزی; Beta-adrenergic receptor (βAR); Beta 2-adrenergic receptor (β2AR); Beta 3-adrenergic receptor (β3AR); Catechol-O-methyltransferase (COMT); Catecholamines; Epinephrine; Norepinephrine; Allodynia; Hyperalgesia; p38; Extracellular signal-regulated kinases
Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats
Keywords: پردردی یا هایپرآلژزی; Bone cancer pain; High-mobility group box 1; PKC; Translocation; Hyperalgesia;
Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?
Keywords: پردردی یا هایپرآلژزی; PDPN; painful diabetic polyneuropathy; PST; pinprick sensitivity threshold; STZ; streptozotocin; Streptozotocin-induced diabetes; Diabetic neuropathy; Evoked pricking pain; Hyperalgesia; Hypoalgesia;
Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition
Keywords: پردردی یا هایپرآلژزی; Mangiferin; Pain; Inflammation; Hyperalgesia;
Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats
Keywords: پردردی یا هایپرآلژزی; Hyperalgesia; Head grooming; CGRP; PACAP; Neuroinflammation; Cerebrolysin;
Age-Dependent Sexual Dimorphism in Susceptibility to Develop Chronic Pain in the Rat
Keywords: پردردی یا هایپرآلژزی; PGE2; prostaglandin E2; PKCε; protein kinase C epsilon; TNFα; tumor necrosis factor α; hyperalgesic priming; hyperalgesia; nociceptor; estrogen; chronic pain; rat;
Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes
Keywords: پردردی یا هایپرآلژزی; Ligustrum vulgare; Diabetic neuropathy; Hyperalgesia; Allodynia; Oleacein; 5-LOX; 5 - lipoxygenase; ACE; angiotensin converting enzyme; CCI; chronic constriction injury; COX-2; cyclooxygenase - 2; DPN; painful diabetic neuropathy; ICAM-1; intercellular ad
Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics
Keywords: پردردی یا هایپرآلژزی; ASIC; acid sensing ion channels; CHO; Chinese hamster ovary; DRG; dorsal root ganglia; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MWT; muscle withdrawal thresho
Kisspeptin modulates pain sensitivity of CFLP mice
Keywords: پردردی یا هایپرآلژزی; Kisspeptin; Nociception; RF-amides; Hyperalgesia; Morphine;
Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain
Keywords: پردردی یا هایپرآلژزی; Serotonin (5-hydroxytryptamine); 8-OH-DPAT (8-hydroxy-2-di-n-propylamino tetralin); Dopamine (3,4-dihydroxyphenyl ethylamine); GABA (Gamma-aminobutyric acid); Morphine (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]i
α-(phenylselanyl) acetophenone abolishes acute restraint stress induced-comorbid pain, depression and anxiety-related behaviors in mice
Keywords: پردردی یا هایپرآلژزی; Antidepressant; Hyperalgesia; Selenium; Anxiety; Organoselenium; Antioxidant;
The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice
Keywords: پردردی یا هایپرآلژزی; Quercetin (PubChem CID: 5,280,343); Quercetin; Titanium dioxide; Arthritis; Hyperalgesia; Osteolysis; Cytokine;
Research articleBotulinum neurotoxin type A alleviates mechanical hypersensitivity associated with infraorbital nerve constriction injury in rats
Keywords: پردردی یا هایپرآلژزی; BoNT-A; ION-CCI; Allodynia; Hyperalgesia; pERK;
Neurotropin® inhibits calpain activity upregulated by specific alternation of rhythm in temperature in the mesencephalon of rats
Keywords: پردردی یا هایپرآلژزی; Neurotropin®; Calpain; SART stress; Hyperalgesia; Mechanical pain threshold; Central nervous system; Munc-18;
Antihyperalgesic activity of a mexicanolide isolated from Swietenia humilis extract in nicotinamide-streptozotocin hyperglycemic mice
Keywords: پردردی یا هایپرآلژزی; Swietenia humilis; 2-Hydroxy-destigloyl-6-deoxyswietenine acetate; Antihyperalgesia; Hyperalgesia; Diabetes; Formalin;
Biochanin-A attenuates neuropathic pain in diabetic rats
Keywords: پردردی یا هایپرآلژزی; Allodynia; Diabetic neuropathy; Hyperalgesia; Isoflavone; Streptozotocin; Hyperglycemia; Paw withdrawal threshold; von Frey filaments;
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors: SAR and in vivo efficacy in hyperalgesia pain model
Keywords: پردردی یا هایپرآلژزی; Arachidonic acid; Rheumatoid arthritis; mPGES-1 inhibitor; PGE2; Aryl imidazole; Hyperalgesia;
Original articleAntinociceptive tolerance to NSAIDs in the rat formalin test is mediated by the opioid mechanism
Keywords: پردردی یا هایپرآلژزی; Antinociception; Descending modulation; Hyperalgesia; Nociception; Non-opioid tolerance;
Anti-inflammatory, and antinociceptive effects of Campomanesia adamantium microencapsulated pulp
Keywords: پردردی یا هایپرآلژزی; Campomanesia adamantium; Inflammation; Hyperalgesia; Microencapsulation; Guavira;
Intraoperative naloxone reduces remifentanil-induced postoperative hyperalgesia but not pain: a randomized controlled trial
Keywords: پردردی یا هایپرآلژزی; hyperalgesia; naloxone; remifentanil;
Discovery of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as potent and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-1
Keywords: پردردی یا هایپرآلژزی; Benzofuran; Prostanoid; Inflammation; Scaffold hopping; Hyperalgesia; PGE2; Osteoarthritis;
Antihyperalgesic effect of CB1 receptor activation involves the modulation of P2X3 receptor in the primary afferent neuron
Keywords: پردردی یا هایپرآلژزی; CB1 receptor; P2X3 receptor; Carrageenan; Hyperalgesia; Rat;
Toluene exposure enhances acute and chronic formalin-induced nociception in rats: Participation of 5-HT3 receptors
Keywords: پردردی یا هایپرآلژزی; Allodynia; 5-HT3 receptors; Hyperalgesia; Toluene; Alosetron;
Diosmin reduces chronic constriction injury-induced neuropathic pain in mice
Keywords: پردردی یا هایپرآلژزی; Neuropathy; Hyperalgesia; Oxidative stress; Flavonoids;
ERK potentiates p38 in central sensitization induced by traumatic occlusion
Keywords: پردردی یا هایپرآلژزی; ATP; adenosine triphosphate; CFA; Complete Freund's Adjuvant; ERK; extracellular signal-regulated kinase; MAPK; P38 mitogen-activated protein kinase; PE; polyethylene; PPT; Pressure pain threshold; TMJs; temporomandibular joint; UAC; unilateral anterior
Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice
Keywords: پردردی یا هایپرآلژزی; CCL5; Hyperalgesia; TRPV1; TRPA1; Cyclooxygenase; Antinociception; Kappa-opioid receptors; Neutrophils; Dynorphin A; Mouse;
Original ArticleNanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides
Keywords: پردردی یا هایپرآلژزی; Fullerene; Radiculopathy; DRG; Inflammasome; Hyperalgesia; Low back pain;
Loss of dopamine D1 receptors and diminished D1/5 receptor-mediated ERK phosphorylation in the periaqueductal gray after spinal cord lesion
Keywords: پردردی یا هایپرآلژزی; DRM; detergent-resistant membranes; DSM; detergent-soluble membranes; ERK1,2; extracellular signal-regulated protein kinases 1 and 2; pERK1,2; phosphorylated ERK 1 and 2; i.p.; intraperitoneal; IPSC; inhibitory post-synaptic potential; PAG; periaqueductal
Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan
Keywords: پردردی یا هایپرآلژزی; 5-HT; 5-hydroxytryptamine; 5-HT1B; 5-hydroxytryptamine receptor subtype 1B; 5-HT1D; 5-hydroxytryptamine receptor subtype 1D; PKA; protein kinase A; GPCR; G-protein-coupled receptor; GPR30; G-protein-coupled estrogen receptor 30; ANOVA; analysis of varianc