3D in vitro modeling of the central nervous system
Keywords: سد خونی مغزی; Tissue engineering; Central nervous systems; Blood-brain barrier; 3D in vitro model;
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Phospholipid transfer protein (PLTP) deficiency impaired blood-brain barrier integrity by increasing cerebrovascular oxidative stress
Keywords: سد خونی مغزی; Phospholipid transfer protein; Blood-brain barrier; Tight junction; Oxidative stress;
Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury
Keywords: سد خونی مغزی; Endogenous PACAP; Plasma; Cerebrospinal fluid; Traumatic brain injury; Neuroprotective; Blood-brain barrier;
Effects of l-tryptophan on l-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque model of Parkinson's disease
Keywords: سد خونی مغزی; 5-HT; 5-Hydroxytryptamine; 5-HTP; 5-Hydroxytryptophan; BBB; Blood-brain barrier; DA; Dopamine; l-DOPA; l-3,4-Dihydroxyphenylalanine; l-AADC; l-Amino acid decarboxylase; LID; l-DOPA-induced dyskinesia; MPTP; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;
Computer simulations and in vivo convection-enhanced delivery of fluorescent nanoparticles demonstrate variable distribution geometry
Keywords: سد خونی مغزی; Convection-enhanced delivery; Nanoparticles; Drug delivery; Blood-brain barrier; Brain cancer;
A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion
Keywords: سد خونی مغزی; White matter injury; Prolonged cerebral hypoperfusion; Matrix metalloproteinase-9; Blood-brain barrier; Edaravone;
TLR2 signaling directs NO-dependent MMP-9 induction in mouse microglia
Keywords: سد خونی مغزی; BBB; blood-brain barrier; CNS; central nervous system; ECM; extracellular matrix; KOdiAPC; 1-(palmitoyl)-2-(5-keto-6-ctene-dioyl)phosphatidylcholine; MMP-9; matrix metalloproteinase-9; MyD88; myeloid differentiation primary response gene (88); NO; nitri
Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model
Keywords: سد خونی مغزی; ARVs; antiretroviral drugs; ABC; ATP-binding cassette; BBB; blood-brain barrier; Bcrp/BCRP; breast cancer resistance protein; CNS; central nervous system; GSH; glutathione; GSSG; glutathione disulfide gp120, HIV-1 glycoprotein-120; HIV; human immunodefi
Novel and functional ABCB1 gene variant in sporadic Parkinson's disease
Keywords: سد خونی مغزی; ABCB1; ATP-binding cassette sub-family B member 1; ATP13A2; Lysosomal P-type transmembrane cation-transporting ATPase, PARK9; BBB; Blood-brain barrier; DJ-1; PARK7 gene; DSVs; DNA sequence variants; FOXO1; Forkhead box factor O1; FOXO3a; Forkhead box fa
ReviewGene therapy for epilepsy
Keywords: سد خونی مغزی; AAV; adeno-associated virus; ADK; adenosine kinase; BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; FIB; fibronectin; FGF-2; fibroblast growth factor 2; GAL; galanin; GDNF; glial cell line-derived neurotrophic factor; HSV; herpes simp
Flavonoid metabolites transport across a human BBB model
Keywords: سد خونی مغزی; ALP; alkaline phosphatase; BBB; blood-brain barrier; CNS; central nervous system; RBE4; rat brain endothelial cell; hCMEC/D3; human brain endothelial cell; Anthocyanins; Blood-brain barrier; Flavanoids; Flavonoids metabolites; hCMEC/D3 cells; Transport;
Clinical NeuroscienceConvection enhanced delivery of carmustine to the murine brainstem: A feasibility study
Keywords: سد خونی مغزی; DIPG; diffuse intrinsic pontine glioma; BiCNU; 1,3-bis-(chloroethyl)-1-nitrosourea; BBB; blood-brain barrier; CED; convection enhanced delivery; GEM; genetically engineered mouse; VUMC; VU University Medical Center; FM; firefly luciferase - mCherry; A
ReviewAlzheimer's and ABC transporters - new opportunities for diagnostics and treatment
Keywords: سد خونی مغزی; AD; Alzheimer's disease; Aβ; amyloid-beta; ABC; ATP binding cassette; BBB; blood-brain barrier; BPND; non-displaceable binding potential; CAA; cerebral amyloid angiopathy; CSF; cerebrospinal fluid; CP; choroid plexus; DLB; dementia with Lewy bodies;
FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation
Keywords: سد خونی مغزی; FTY720; Traumatic brain injury; Inflammation; Blood-brain barrier; Lymphocytes; Edema;
Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway
Keywords: سد خونی مغزی; UA; ursolic acid; EBI; early brain injury; SAH; subarachnoid hemorrhage; BBB; blood-brain barrier; TLR4; toll-like receptor 4; ICAM-1; intercellular adhesion molecule-1; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; iNOS; inducible nitric oxide
Regular ArticleCannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats
Keywords: سد خونی مغزی; EBI; early brain injury; SAH; subarachnoid hemorrhage; CB2R; cannabinoid receptor type 2; CREB; cAMP response element-binding protein; siRNA; small interfering ribonucleic acid; pCREB; phosphorylated CREB; BBB; blood-brain barrier; CB1R; cannabinoid rec
Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model
Keywords: سد خونی مغزی; Blood-brain barrier; Central nervous system; Delayed-type hypersensitivity model; Fingolimod; Lesion; Multiple sclerosis; BBB; blood-brain barrier; BCG; bacillus Calmette-Guérin; CNS; central nervous system; DTH; delayed-type hypersensitivity; DTPA
Quick adjustment of imaging tracer payload, for in vivo applications of theranostic nanostructures in the brain
Keywords: سد خونی مغزی; BBB; Blood-brain Barrier; DLS; Dynamic Light Scattering; DSPC; 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; FOV; Field of view; Gd; Gadolinium; Gd-DTPA; Gadolinium diethylenetriaminepenta-acetate; Gd-DTPA-BSA; diethylenetriaminepentaacetic acid-bis(s
Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats
Keywords: سد خونی مغزی; AD; Alzheimer's disease; Aβ; amyloid β; ANOVA; analysis of variance; BBB; blood-brain barrier; DPPIV; DPPIV dipeptidyl peptidase IV; fEPSPs; Field excitatory postsynaptic potentials; GLP-1; glucagon-like peptide-1; GLP-1R; GLP-1 receptor; GSK3β; gl
An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture
Keywords: سد خونی مغزی; Blood-brain barrier; Human endothelial cell line; Human astrocyte cell line; In vitro model; Shear forces; Leukocyte transmigration; Co-culture; Migration assay;
Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease
Keywords: سد خونی مغزی; Liposomes; ApoE peptide; Abeta peptide; Blood-brain barrier; Alzheimer disease;
Evidences of endocytosis via caveolae following blood-brain barrier breakdown by Phoneutria nigriventer spider venom
Keywords: سد خونی مغزی; BBB; blood-brain barrier; Cav-1; caveolin-1; CNS; central nervous system; GL; granular layer; ML; molecular layer; PC; Purkinje cells; PL; Purkinje layer; PNV; Phoneutria nigriventer venom; BBB; Caveolin-1; Endocytosis; Lipid rafts; Transcellular traffi
Lack of dystrophin results in abnormal cerebral diffusion and perfusion in vivo
Keywords: سد خونی مغزی; MRI; magnetic resonance imaging; BBB; blood-brain barrier; DGC; dystrophin-glycoprotein complex; DMD; Duchenne muscular dystrophy; IQ; intelligence quotient; MMP; matrix-metalloproteinase; ASL; arterial spin labeling; DCE; dynamic contrast enhanced; D
Association of rs2075575 and rs9951307 Polymorphisms of AQP-4 Gene with Leukoaraiosis
Keywords: سد خونی مغزی; Leukoaraiosis; genetic polymorphism; blood-brain barrier; aquaporin-4;
Redistribution of PDGFRβ cells and NG2DsRed pericytes at the cerebrovasculature after status epilepticus
Keywords: سد خونی مغزی; Pericytes; PDGFRβ; NG2DsRed; Blood-brain barrier; Status epilepticus;
Solid Lipid Nanoparticles for Potential Doxorubicin Delivery in Glioblastoma Treatment: Preliminary In Vitro Studies
Keywords: سد خونی مغزی; SLN; coacervation; nanoparticles; doxorubicin; ion pairing; blood-brain barrier; glioblastoma; CNS;
Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand
Keywords: سد خونی مغزی; ABC-transporter; ATP-binding cassette transporter; BBB; blood-brain barrier; Calcein-AM; calcein acetoxymethylester; EC50; 50% effective concentration; ECmax; maximal effective concentration; HPLC; high pressure liquid chromatography; IC50; 50% inhibito
Dynamic changes of Apo A1 mediated by LXR/RXR/ABCA1 pathway in brains of the aging rats with cerebral hypoperfusion
Keywords: سد خونی مغزی; AD; Alzheimer's disease; VD; vascular dementia; BBB; blood-brain barrier; ABCA1; ATP-binding cassette transporter A1; HDL; high-density lipoprotein; LXR; liver X receptor; RXR; retinoid X receptor; 2VO; 2 vessel occlusion; Vascular dementia; Liver X rec
Early reperfusion injury is associated to MMP2 and IL-1β elevation in cortical neurons of rats subjected to middle cerebral artery occlusion
Keywords: سد خونی مغزی; ANOVA; analysis of variance; BBB; blood-brain barrier; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfoxide; DQ; dye-quenched; ELISA; enzyme-linked immunosorbent assay; FITC; fluorescein isothiocyanate; IL; interleukin; MCAo;
Phosphorylation enhances recombinant HSP27 neuroprotection against focal cerebral ischemia in mice
Keywords: سد خونی مغزی; BBB; blood-brain barrier; BSA; bovine serum albumin; FITC; fluorescein isothiocyanate; HSP27; heat shock protein 27; hHSP27; HSP27, purified from human lymphocytes; Iba-1; ionized calcium binding adapter molecule-1; MCAO; middle cerebral artery occlusio
Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
Keywords: سد خونی مغزی; AVP; arginine vasopressin; BBB; blood-brain barrier; BP; blood pressure; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; H/R; hypoxia and reoxygenation; KA; kainic acid; MCAO; middle cerebral artery occlusion; NGF; nerve growth fa
Cerebrospinal fluid apolipoprotein E and phospholipid transfer protein activity are reduced in multiple sclerosis; relationships with the brain MRI and CSF lipid variables
Keywords: سد خونی مغزی; ApoE; apolipoprotein E (protein); APOE; apolipoprotein E (gene); BBB; blood-brain barrier; BH; black hole lesion load (BH); CSF; cerebrospinal fluid; EDSS; Expanded Disability Status Scale; GAD; gadolinium-enhancing lesions; GC-MS; gas chromatography
Atg5 deficit exaggerates the lysosome formation and cathepsin B activation in mice brain after lipid nanoparticles injection
Keywords: سد خونی مغزی; Atg5; Autophagy protein 5; BBB; Blood-brain barrier; BSA; Bovine serum albumin; DAPI; 4â²,6-Diamidino-2-phenylindole; CaMKII; Calcium/calmodulin-dependent kinase II; LAMP-2; Lysosome-associated membrane protein 2; LC3-I/II; Microtubule-associated prote
Selective chaperone effect of aminocyclitol derivatives on G202R and other mutant glucocerebrosidases causing Gaucher disease
Keywords: سد خونی مغزی; BBB; blood-brain barrier; CBE; conduritol β-epoxide; Cer; ceramide; D-MEM; Dulbeco Eagle's minimal essential medium; ERT; enzyme replacement therapy; GBA1; lysosomal glucocerebrosidase; GBA2; non-lysosomal glucocerebrosidase; GlcCer; glucosylceramide;
Neamine induces neuroprotection after acute ischemic stroke in type one diabetic rats
Keywords: سد خونی مغزی; Ang1; angiopoietin-1; BBB; blood-brain barrier; BT; body temperature; BP; blood pressure; DM; diabetes mellitus; ECA; external carotid artery; ECM; extracellular matrix; IBZ; ischemic border area; ICA; internal carotid artery; MCAo; middle cerebral arte
Research ReportInhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in mice
Keywords: سد خونی مغزی; PAK1; p21-activated kinase 1; TBI; traumatic brain injury; BBB; blood-brain barrier; CNS; central nervous system; TUNEL; terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling; IF; immunofluorescence; PCR; polymerase chain reaction; SAH; s
Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model
Keywords: سد خونی مغزی; Multidrug transporter; Blood-brain barrier; NMDA receptor; Drug resistance; Glycine-binding site;
Enhanced Glioma Targeting and Penetration by Dual-Targeting Liposome Co-modified with T7 and TAT
Keywords: سد خونی مغزی; dual targeting; pharmacokinetics; distribution; stability; blood-brain barrier;
Protection of SK-N-MC cells against β-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin
Keywords: سد خونی مغزی; Alzheimer's disease; Blood-brain barrier; Lactoferrin; Neuron growth factor; Liposome; SK-N-MC cell;
HIV-1 stimulates nuclear entry of amyloid beta via dynamin dependent EEA1 and TGF-β/Smad signaling
Keywords: سد خونی مغزی; HIV-1; Blood-brain barrier; Amyloid beta;
Basic NeuroscienceInterleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model
Keywords: سد خونی مغزی; Blood-brain barrier; Transwell model; THBMEC; Transmigration; Inflammation; Interleukin-1β;
Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion
Keywords: سد خونی مغزی; Ang-1; angiopoietin-1; Ang-2; angiopoietin-2; BBB; blood-brain barrier; DMSO; dimethyl sulfoxide; EB; Evans blue; MCAO; middle cerebral artery occlusion; MW; molecular weight; PP1; 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; PP3; 4-
Research reportOrosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse
Keywords: سد خونی مغزی; Blood-brain barrier; Vascular endothelial growth factor; Stroke; Microarray analysis; Orosomucoid; NF-κB; VEGF; vascular endothelial growth factor; BBB; blood-brain barrier; Orm; orosomucoid; MCAO; middle cerebral artery occlusion; MCA; middle cerebr
Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood-brain barrier model
Keywords: سد خونی مغزی; HIV-1; Central nervous system; Leukotrienes; Blood-brain barrier;
In-silico analysis of claudin-5 reveals novel putative sites for post-translational modifications: Insights into potential molecular determinants of blood-brain barrier breach during HIV-1 infiltration
Keywords: سد خونی مغزی; Blood-brain barrier; Brain endothelial cells; Tight junctions; Post-translational modifications in claudin-5; HIV-1;
Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e PrÃncipe
Keywords: سد خونی مغزی; Aβ; amyloid beta peptide; AD; Alzheimer׳s disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; BBB; blood-brain barrier; CLogP; lipophilicity; CNS; Central nervous system; DMEM; Dulbecco׳s modified Eagle׳s medium; ESI; Electrospray
Delivering etoposide to the brain using catanionic solid lipid nanoparticles with surface 5-HT-moduline
Keywords: سد خونی مغزی; 5-HT-moduline; 5-hydroxytryptamine-moduline (tetrapeptide Leu-Ser-Ala-Leu); 5-HT-moduline/ETP-CASLN; 5-HT-moduline-grafted ETP-encapsulated catanionic solid lipid nanoparticle; BBB; blood-brain barrier; CASLN; catanionic solid lipid nanoparticle (with D
Pharmaceutical nanotechnologyCardiolipin-incorporated liposomes with surface CRM197 for enhancing neuronal survival against neurotoxicity
Keywords: سد خونی مغزی; AD; Alzheimer's disease; Aβ1-42; β-amyloid peptide (1-42); BBB; blood-brain barrier; CL; cardiolipin, diphosphatidylglycerol; CL-liposome; cardiolipin-incorporated liposome (without surface CRM197); CNS; central nervous system; CRM197; cross-rea
Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells
Keywords: سد خونی مغزی; AREs; AU-rich elements; BBB; blood-brain barrier; C/EBPβ; CCAAT enhancer binding protein beta; CNS; central nervous system; COX-2; cyclooxygenase-2; HAT; histone acetyltransferase; HDAC; histone deacetylase; JNK; c-Jun N-terminal kinase; LPS; lipopolys
Involvement of the blood-brain barrier opening in cognitive decline in aged rats following orthopedic surgery and high concentration of sevoflurane inhalation
Keywords: سد خونی مغزی; Sevoflurane; Orthopedic surgery; Blood-brain barrier; Tight junction; Matrix metalloproteinase-2,9;