Rapamycin down-regulates LDL-receptor expression independently of SREBP-2
Keywords: راپامایسین; SREBP-2; Rapamycin; Sirolimus; mTOR; LDL-receptor; Hyperlipidemia;
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Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, rapamycin and paclitaxel
Keywords: راپامایسین; Tissue factor; SMC; Rapamycin; Paclitaxel; Irradiation
Frequency modulation of synchronized Ca2+ spikes in cultured hippocampal networks through mTOR
Keywords: راپامایسین; mTOR; Rapamycin; Insulin; Ca2+ spike
Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
Keywords: راپامایسین; Angiogenesis; Spheroid; RPE; Endothelial; CNV; Rapamycin
Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A
Keywords: راپامایسین; IL-18; Dendritic cells; Rapamycin; Sanglifehrin A; Cyclosporin A
Targeting AMPK: A new therapeutic opportunity in breast cancer
Keywords: راپامایسین; Cancer; Breast cancer; mTOR; AMPK; TSC; Akt; Rapamycin; Metformin
Mass balance in rapamycin autoxidation
Keywords: راپامایسین; Rapamycin; Autoxidation; Mass balance; SEC; RP-HPLC
Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells
Keywords: راپامایسین; Autophagy; Neuronal differentiation; N2a cells; mTOR; Rapamycin
TOR signaling is required for amino acid stimulation of early trypsin protein synthesis in the midgut of Aedes aegypti mosquitoes
Keywords: راپامایسین; Rapamycin; RNAi; 4E-BP; p70S6 Kinase; Translational control; Blood meal metabolism
Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation
Keywords: راپامایسین; mTOR; Reconsolidation; Consolidation; Fear conditioning; Posttraumatic stress disorder; Extinction; Learning and memory; Rapamycin
Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation
Keywords: راپامایسین; Rapamycin; Toll-like receptor 4; Colon cancer; NF-κB; Interleukin-6; Prostaglandin E2
Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells
Keywords: راپامایسین; Chemokine CXCL12; Peritoneal carcinomatosis of gastric cancer; mTOR; Rapamycin
Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
Keywords: راپامایسین; HCC; Hepatocellular carcinoma; VEGF; vascular endothelial growth factor; BEV; Bevacizumab; mTOR; mammalian target-of-rapamycin; p70S6K; p70S6 kinase; RPS6; ribosomal S6 protein; 4EBP1; eukaryotic initiation factor 4E-binding protein 1; RAPA; rapamycin; IP
Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer
Keywords: راپامایسین; Honokiol; Proliferation; Apoptosis; Lapatinib; Rapamycin
Protein nanoparticles as drug carriers in clinical medicine
Keywords: راپامایسین; Albumin; nab-Paclitaxel; Paclitaxel; Abraxane; Polyethoxylated castor oil; Docetaxel; Polysorbate 80; SPARC; gp60; Rapamycin
Combination of rapamycin and IL-2 increases de novo induction of human CD4+CD25+FOXP3+ T cells
Keywords: راپامایسین; FOXP3; IL-2; Immune regulation; Rapamycin; TregInduced Treg, iTreg; Rapamycin, rapa; Natural Treg, nTreg
Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells
Keywords: راپامایسین; Pancreas cancer model; Gefitinib; Rapamycin; EGFR; mTor;
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
Keywords: راپامایسین; Autophagy; Lactacystin; Parkinson's disease; Rapamycin; Ubiquitin–proteasome system
Long-term effects of rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen synthase activity
Keywords: راپامایسین; Rapamycin; Insulin; Akt/PKB phosphorylation; IRS-1; Glycogen synthase; Protein phosphatase-1; HepG2 cells
Ethylenecarbodiimide-coupled allogeneic antigen presenting cells induce human CD4+ regulatory T cells
Keywords: راپامایسین; CFSE, carboxyfluorescein diacetate, succinimidyl ester; ECDI, ethylenecarbodiimide; GVHD, graft-versus-host disease; MLR, mixed lymphocyte reaction; APC, antigen presenting cellsECDI; Treg; Rapamycin; GVHD
ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
Keywords: راپامایسین; HCC; hepatocellular carcinoma; RTKIs; tyrosine kinase inhibitors; MAPK; mitogen activated protein kinase; VEGF; vascular endothelial growth factor; mTOR; mammalian target of rapamycin; p70S6K; p70S6 kinase; 4EBP1; eukaryotic initiation factor 4E-binding p
On the participation of mTOR in recognition memory
Keywords: راپامایسین; Memory; Object recognition; Consolidation; Reconsolidation; mTOR; Rapamycin; Hippocampus; Protein synthesis; Learning
Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
Keywords: راپامایسین; PI3 kinase; Akt; Combination; Chemotherapy; Cancer; Wortmannin; PX-866; Perfosine; mTOR inhibitors; Rapamycin; RAD-001; PI-103; Triciribine (API-2)
Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations
Keywords: راپامایسین; Imatinib; Curcumin; Cyclosporine; Rapamycin; Smoothelin; S100A4
mTOR signaling in the hippocampus is necessary for memory formation
Keywords: راپامایسین; mTOR; Rapamycin; Hippocampus; Memory consolidation; Protein synthesis
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
Keywords: راپامایسین; Rapamycin; CD4+CD25+FoxP3+ T regulatory cells; Th17 cells
Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae
Keywords: راپامایسین; ATG genes, autophagy-related genes; Cvt, cytoplasm to vacuole targeting; GFP, green fluorescent protein; PAS, pre-autophagosomal structureAutophagy; Starvation; ATG; Autophagosome; PAS; Rapamycin
Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro
Keywords: راپامایسین; Rapamycin; Hepatocellular carcinoma; Caspase-3; Mitochondrial membrane potential; Bcl-2
Increased iNOS-expressing macrophage in long-term surviving rat small-bowel grafts
Keywords: راپامایسین; Chronic rejection; Fibrosis; FK506; rapamycin; Vasculopathy
Improved blood compatibility of rapamycin-eluting stent by incorporating curcumin
Keywords: راپامایسین; Drug-eluting stent; Rapamycin; Curcumin; Blood compatibility
Rapamycin Inhibits Proliferation of Estrogen-Receptor-Positive Breast Cancer Cells
Keywords: راپامایسین; rapamycin; estrogen receptor; breast cancer; tamoxifen
Effects of rapamycin on cell proliferation and phosphorylation of mTOR and p70S6K in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB
Keywords: راپامایسین; Human liver carcinoma cells; Constitutively active Akt/PKB; mTOR; p70S6k; Rapamycin
Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
Keywords: راپامایسین; Rapamycin; Tuberous sclerosis; Gene expression; Bicuculline; Epilepsy;
Identification of AUF1 as a rapamycin-responsive binding protein to the 5′-terminal oligopyrimidine element of mRNAs
Keywords: راپامایسین; Translational control; Rapamycin; Terminal oligopyrimidine tract; AUF1
Rapamycin is a neuroprotective treatment for traumatic brain injury
Keywords: راپامایسین; Autophagy; Beclin 1; Brain; Neurons; Rapamycin; Closed head injury
Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis
Keywords: راپامایسین; Rapamycin; mTOR; Glioblastoma; Local tumour control; Hypoxia; Thrombosis
Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer
Keywords: راپامایسین; Akt; mTOR; p70 S6K; Rapamycin; Colorectal cancer
The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast
Keywords: راپامایسین; Ergosterol; Zaragozic acid; Rapamycin; Tryptophan; Tat2p;
Monitoring Biological Action of Rapamycin in Renal Transplantation
Keywords: راپامایسین; Kidney transplantation; rapamycin; tacrolimus; P70S6 kinase; peripheral-blood mononuclear cells; in vivo assay;
Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation
Keywords: راپامایسین; Mitochondria; mtDNA; Biogenesis; Protein kinase C; Calcium; Signaling; AMP-activated protein kinase; mTOR; Rapamycin; Ionomycin; Membrane potential; Oxidative phosphorylation; T cell; Cytokine; T cell receptor
Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for rapamycin analog ABT-578: Application to active pharmaceutical ingredient process development
Keywords: راپامایسین; Drug-eluting stent; Zotarolimus; ABT-578; Rapamycin; Sirolimus; RP-HPLC-UV-MS; NP-HPLC-UV-MS; Process impurities; API process analytical development; Impurities tracking and mapping; HPLC impurity profile
An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by rapamycin and siRNA against mTOR
Keywords: راپامایسین; mTOR; p70S6K; Rapamycin; siRNA; Apoptosis; Esophageal squamous cell carcinoma
Rapamycin enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis
Keywords: راپامایسین; immunotherapy; rapamycin; Treg
A kinetically trapped intermediate of FK506 binding protein forms in vitro: Chaperone machinery dominates protein folding in vivo
Keywords: راپامایسین; Hexa-histidine tags; FK506 binding protein; Refolding; Peptidyl–prolyl isomerase; Rapamycin
Sirolimus-Induced Pulmonary Hypersensitivity Associated With a CD4 T-Cell Infiltrate
Keywords: راپامایسین; hypersensitivity; liver; rapamycin; sirolimus; transplantationBOOP, bronchiolitis obliterans organizing pneumonia; CNI, calcineurin inhibitor; HCV, hepatitis C virus; GIP, granulomatous interstitial pneumonitis; OP, organizing pneumonia; SRL-IPH, sirolimu
Stimulation of the intestinal phosphate transporter SLC34A2 by the protein kinase mTOR
Keywords: راپامایسین; Serum and glucocorticoid inducible kinase SGK1; Na+ coupled transport; Rapamycin
Stimulation of the creatine transporter SLC6A8 by the protein kinase mTOR
Keywords: راپامایسین; Skeletal muscle; Kidney; Heart; Brain; Creatine; Rapamycin
A role for the mTOR pathway in surface expression of AMPA receptors
Keywords: راپامایسین; AMPARs; Rapamycin; Receptor expression; mTOR; Neuronal culture; GluR2/3 subunits;
Evaluation of rapamycin chemical stability in volatile-organic solvents by HPLC
Keywords: راپامایسین; Rapamycin; Stability; HPLC; NMR
Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice
Keywords: راپامایسین; Diabetic nephropathy; Renal hypertrophy; Mammalian target of rapamycin; Rapamycin