
Endomorphin-1 analogues (MELs) penetrate the blood-brain barrier and exhibit good analgesic effects with minimal side effects
Keywords: تلرانس ; Antinociception; Blood-brain barrier; Constipation; Endomorphin; Tolerance; BBB; bloodâbrain barrier; cAMP; cyclic adenosine monophosphate; CCI; chronic constriction injury; CNS; central nervous system; DOR; δ opioid receptor; EM-1; endomorphin-1; EM