Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABAA α5 inverse agonist for cognitive dysfunction Fulltext Access 4 Pages 2006
Inhibiting protein–amyloid interactions with small molecules: A surface chemistry approach Fulltext Access 4 Pages 2006
η4-Pyrone iron(0)carbonyl complexes as effective CO-releasing molecules (CO-RMs) Fulltext Access 4 Pages 2006
Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents Fulltext Access 4 Pages 2006
Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists Fulltext Access 4 Pages 2006
Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands Fulltext Access 4 Pages 2006
Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent Fulltext Access 4 Pages 2006
Design and total synthesis of a fluorescent phorboxazole a analog for cellular studies Fulltext Access 4 Pages 2006
Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BKCa) Fulltext Access 4 Pages 2006
Pyridazines part 41: Synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones Fulltext Access 4 Pages 2006
Conformation stability and organization of mefloquine molecules in different environments Fulltext Access 4 Pages 2006
From genome to drug lead: Identification of a small-molecule inhibitor of the SARS virus Fulltext Access 4 Pages 2006
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ Fulltext Access 4 Pages 2006
Synthesis and structure–activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists Fulltext Access 4 Pages 2006
Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease Fulltext Access 4 Pages 2006
Design, synthesis, and biological evaluation of BODIPY®–erythromycin probes for bacterial ribosomes Fulltext Access 4 Pages 2006
Isolation, synthesis, and anti-tumor activities of a novel class of podocarpic diterpenes Fulltext Access 4 Pages 2006
Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells Fulltext Access 4 Pages 2006
Concise and efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivatives: Dual agonists for human peroxisome proliferator-activated receptor α and δ Fulltext Access 4 Pages 2006
Use of the organotypic culture method to investigate drug-loaded CSF shunt Fulltext Access 4 Pages 2006
Conception du service de stérilisation centralisé du groupe hospitalier Pellegrin au CHU de Bordeaux Fulltext Access 4 Pages 2006
Contrat de bon usage : revue d'utilisation des érythropoïétines au CHU de Limoges Fulltext Access 4 Pages 2006
Determination of Pulmozyme® (dornase alpha) stability using a kinetic colorimetric DNase I activity assay Fulltext Access 4 Pages 2006
Investigation of the glidant properties of compacted colloidal silicon dioxide by angle of repose and X-ray photoelectron spectroscopy Fulltext Access 4 Pages 2006
Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors Fulltext Access 4 Pages 2006
Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles Fulltext Access 4 Pages 2006
Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption Fulltext Access 4 Pages 2006
Synthesis and QSAR studies of novel 1-substituted-2-aminobenzimidazoles derivatives Fulltext Access 4 Pages 2006
Trypanocidal activity of 5,6-dihydropyran-2-ones against free trypomastigotes forms of Trypanosoma cruzi Fulltext Access 4 Pages 2006
An efficient approach to the asymmetric total synthesis of (–)-anisodine Fulltext Access 4 Pages 2006
An approach to the stereo-controlled synthesis of polycyclic derivatives of l-4-thiazolidinecarboxylic acid active against HIV-1 integrase Fulltext Access 4 Pages 2006
Correlation of calculated molecular orbital energies of some phenothiazine compounds with MDR reversal properties Fulltext Access 4 Pages 2006
Identification and stereochemistry of the product of 4-HPPD catalyzed oxidation of the ketoacid of methionine Fulltext Access 4 Pages 2006
Synthesis and antiproliferative activity of two new tiazofurin analogues with 2′-amido functionalities Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of a novel structural type of serotonin 5-HT3 receptor antagonists Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs Fulltext Access 4 Pages 2006
The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases Fulltext Access 4 Pages 2006
Studies on the novel α-glucosidase inhibitory activity and structure–activity relationships for andrographolide analogues Fulltext Access 4 Pages 2006
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2 Fulltext Access 4 Pages 2006
Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher Fulltext Access 4 Pages 2006
Synthesis of a potent 5′-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor Fulltext Access 4 Pages 2006
Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands Fulltext Access 4 Pages 2006
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2 Fulltext Access 4 Pages 2006
Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin Fulltext Access 4 Pages 2006
Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate Fulltext Access 4 Pages 2006
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead Fulltext Access 4 Pages 2006
Human methionine aminopeptidase type 2 in complex with l- and d-methionine Fulltext Access 4 Pages 2006
Synthesis and antitumor activity of 7-ethyl-9-alkyl derivatives of camptothecin Fulltext Access 4 Pages 2006
Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase Fulltext Access 4 Pages 2006
Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid Fulltext Access 4 Pages 2006
N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor Fulltext Access 4 Pages 2006
Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K Fulltext Access 4 Pages 2006
Discovery and SAR study of novel dihydroquinoline containing glucocorticoid receptor ligands Fulltext Access 4 Pages 2006
Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists Fulltext Access 4 Pages 2006
Design and modular parallel synthesis of a MCR derived α-helix mimetic protein–protein interaction inhibitor scaffold Fulltext Access 4 Pages 2006
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1 Fulltext Access 4 Pages 2006
Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication Fulltext Access 4 Pages 2006
Synthesis and biological activity of (+)-hedychilactone A and its analogs from (+)-sclareolide Fulltext Access 4 Pages 2006
DNA triplex stabilization by a δ-carboline derivative tethered to third strand oligonucleotides Fulltext Access 4 Pages 2006
Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors Fulltext Access 4 Pages 2006
Synthesis and evaluation of an N-acylated photoactivatable analogue of glutathione as probe for glutathione-utilizing enzymes Fulltext Access 4 Pages 2006
Novel dual inhibitors of calpain and lipid peroxidation with enhanced cellular activity Fulltext Access 4 Pages 2006
Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as α2/α3 subtype selective GABAA agonists for the treatment of anxiety Fulltext Access 4 Pages 2006
Structure–activity relationship studies on niphimycin, a guanidylpolyol macrolide antibiotic. Part 1: The role of the N-methyl-N″-alkylguanidinium moiety Fulltext Access 4 Pages 2006
Cyclodextrin retinylidene: A biomimetic kinetic trap model for rhodopsin Fulltext Access 4 Pages 2006
Schiff base conjugates of p-aminosalicylic acid as antimycobacterial agents Fulltext Access 4 Pages 2006
Synthesis and biological investigation of new 4″-malonyl tethered derivatives of erythromycin and clarithromycin Fulltext Access 4 Pages 2006
4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors Fulltext Access 4 Pages 2006
Synthesis and screening of bicyclic carbohydrate-based compounds: A novel type of antivirals Fulltext Access 4 Pages 2006
Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies Fulltext Access 4 Pages 2006
Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety Fulltext Access 4 Pages 2006
Design of novel synthetic MTS conjugates of bile acids for site-directed sulfhydryl labeling of cysteine residues in bile acid binding and transporting proteins Fulltext Access 4 Pages 2006