Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides Fulltext Access 4 Pages 2006
Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1 Fulltext Access 4 Pages 2006
Effect of 4-substitution on psychotomimetic activity of 2,5-dimethoxy amphetamines as studied by means of different substituent parameter scales Fulltext Access 4 Pages 2006
Synthesis and structure–activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings Fulltext Access 4 Pages 2006
Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids Fulltext Access 4 Pages 2006
Cell permeation of a Trypanosoma brucei aldolase inhibitor: Evaluation of different enzyme-labile phosphate protecting groups Fulltext Access 4 Pages 2006
Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1 Fulltext Access 4 Pages 2006
Antidyslipidemic activity of furano-flavonoids isolated from Indigofera tinctoria Fulltext Access 4 Pages 2006
Small-molecule microarrays: Development of novel linkers and an efficient detection method for bound proteins Fulltext Access 4 Pages 2006
Regioselective and stereospecific cleavage of a terminal oxirane system: A novel synthetic approach to lipid mediator congeners—1,2(2,3)-diacyl-3(1)-halo-sn-glycerols Fulltext Access 4 Pages 2006
Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity Fulltext Access 4 Pages 2006
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides Fulltext Access 4 Pages 2006
Magnetic resonance imaging of tumor cells by targeting the amino acid transport system Fulltext Access 4 Pages 2006
Synthesis and structure–activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonists Fulltext Access 4 Pages 2006
Proton dissociation is important to understanding structure–activity relationships of gallic acid antioxidants Fulltext Access 4 Pages 2006
Synthesis and biological activity of nociceptin/orphanin FQ(1–13)NH2 analogues modified in 9 and/or 13 position Fulltext Access 4 Pages 2006
Lipase catalyzed synthesis of benzyl acetate in solvent-free medium using vinyl acetate as acyl donor Fulltext Access 4 Pages 2006
Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications Fulltext Access 4 Pages 2006
Discovery of protein–protein binding disruptors using multi-component condensations small molecules Fulltext Access 4 Pages 2006
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors Fulltext Access 4 Pages 2006
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring Fulltext Access 4 Pages 2006
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors Fulltext Access 4 Pages 2006
An exploratory theoretical elucidation on the peroxyl-radical-scavenging mechanism and structure-activity relationship of nonsteroidal anti-inflammatory drugs Fulltext Access 4 Pages 2006
Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity Fulltext Access 4 Pages 2006
Racemic and chiral sulfoxides as potential prodrugs of the COX-2 inhibitors Vioxx® and Arcoxia® Fulltext Access 4 Pages 2006
A practical synthesis of the major 3-hydroxy-2-pyrrolidinone metabolite of a potent CDK2/cyclin A inhibitor Fulltext Access 4 Pages 2006
Fluorophor-labeled spermidine derivatives as fluorescent markers in optical tumor imaging Fulltext Access 4 Pages 2006
Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G Fulltext Access 4 Pages 2006
DNA and LNA oligonucleotides containing N2′-functionalised derivatives of 2′-amino-2′-deoxyuridine Fulltext Access 4 Pages 2006
Benzo[b]thiophene-2-carboxamides and benzo[b]furan-2-carboxamides are potent antagonists of the human H3-receptor Fulltext Access 4 Pages 2006
One-pot synthesis and SAR study of cis-2,6-dialkyl-4-chloro-tetrahydropyrans Fulltext Access 4 Pages 2006
A ratiometric fluorescent sensor for Zn2+ based on internal charge transfer (ICT) Fulltext Access 4 Pages 2006
The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors Fulltext Access 4 Pages 2006
Stereoselective synthesis of dinucleoside boranophosphates by an oxazaphospholidine method Fulltext Access 4 Pages 2006
Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors Fulltext Access 4 Pages 2006
Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors Fulltext Access 4 Pages 2006
Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA Fulltext Access 4 Pages 2006
The ortho hydroxy-amino group: Another choice for synthesizing novel antioxidants Fulltext Access 4 Pages 2006
New potential inhibitors of cyclin-dependent kinase 4: Design and synthesis of pyrido[2,3-d]pyrimidine derivatives under microwave irradiation Fulltext Access 4 Pages 2006
Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties Fulltext Access 4 Pages 2006
Function of the alkyl side chains of Δlac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase) Fulltext Access 4 Pages 2006
Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors Fulltext Access 4 Pages 2006
Regiospecific one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives in the solid state under microwave irradiations Fulltext Access 4 Pages 2006
Inhibition of P-glycoprotein-mediated multidrug efflux by aminomethylene and ketomethylene analogs of reversins Fulltext Access 4 Pages 2006
Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors Fulltext Access 4 Pages 2006
Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase Fulltext Access 4 Pages 2006
Optimization of pyrimidinyl- and triazinyl-amines as non-nucleoside inhibitors of HIV-1 reverse transcriptase Fulltext Access 4 Pages 2006
Chemical transformations of oxyresveratrol (trans-2,4,3′,5′-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent Fulltext Access 4 Pages 2006
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands Fulltext Access 4 Pages 2006
Comparison between two classes of selective EP3 antagonists and their biological activities Fulltext Access 4 Pages 2006
Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues Fulltext Access 4 Pages 2006
Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis Fulltext Access 4 Pages 2006
A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors Fulltext Access 4 Pages 2006
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide Fulltext Access 4 Pages 2006
An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors Fulltext Access 4 Pages 2006
Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata Fulltext Access 4 Pages 2006
Potent inhibitors of lipoprotein-associated phospholipase A2: Benzaldehyde O-heterocycle-4-carbonyloxime Fulltext Access 4 Pages 2006
Controlled release of DNA/polyamine complex by photoirradiation of a solid phase presenting o-nitrobenzyl ether tethered spermine or polyethyleneimine Fulltext Access 4 Pages 2006
Design of inhibitors against guanase: Synthesis and biochemical evaluation of analogues of azepinomycin Fulltext Access 4 Pages 2006
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine Fulltext Access 4 Pages 2006
Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists Fulltext Access 4 Pages 2006
Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents Fulltext Access 4 Pages 2006
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A1 receptor Fulltext Access 4 Pages 2006
N,N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of type VI β-turn templated RGD peptidomimetics Fulltext Access 4 Pages 2006
m-Carborane bisphenol structure as a pharmacophore for selective estrogen receptor modulators Fulltext Access 4 Pages 2006
Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth Fulltext Access 4 Pages 2006
Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents Fulltext Access 4 Pages 2006
A diversity oriented synthesis of 3′-O-modified nucleoside triphosphates for DNA ‘sequencing by synthesis’ Fulltext Access 4 Pages 2006
Himbacine derived thrombin receptor (PAR-1) antagonists: Structure–activity relationship of the lactone ring Fulltext Access 4 Pages 2006
4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate Fulltext Access 4 Pages 2006
Structure–activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells Fulltext Access 4 Pages 2006
Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis Fulltext Access 4 Pages 2006
Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: Orally active prostacyclin mimetics. Part 6 Fulltext Access 4 Pages 2006
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX Fulltext Access 4 Pages 2006
Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor Fulltext Access 4 Pages 2006
Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: A new class of cytotoxic compounds Fulltext Access 4 Pages 2006
Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors Fulltext Access 4 Pages 2006
Total synthesis and biological evaluation of ustiloxin natural products and two analogs Fulltext Access 4 Pages 2006
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors Fulltext Access 4 Pages 2006
A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5) Fulltext Access 4 Pages 2006
Structure–activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5) Fulltext Access 4 Pages 2006
Exploring alternative Zn-binding groups in the design of HDAC inhibitors: Squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA Fulltext Access 4 Pages 2006
Effects of vitamins, coenzymes and amino acids on reactions of homolytic cleavage of the O-glycoside bond in carbohydrates Fulltext Access 4 Pages 2006