Synthesis of linked triple helical DNAs possessing high affinity to triple helical DNA binding protein Fulltext Access 4 Pages 2006
Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives Fulltext Access 4 Pages 2006
Tethering identifies fragment that yields potent inhibitors of human caspase-1 Fulltext Access 4 Pages 2006
Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel gating Fulltext Access 4 Pages 2006
In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors Fulltext Access 4 Pages 2006
Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs Fulltext Access 4 Pages 2006
A PNA-DNA hybridization chip approach for the detection of β-secretase activity Fulltext Access 4 Pages 2006
Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells Fulltext Access 4 Pages 2006
Inactivation of medium-chain acyl-CoA dehydrogenase by oct-4-en-2-ynoyl-CoA Fulltext Access 4 Pages 2006
4-Methylideneisoxazolidin-5-ones—A new class of α-methylidene-γ-lactones with high cytostatic activity Fulltext Access 4 Pages 2006
Anion of hypericin is crucial to understanding the photosensitive features of the pigment Fulltext Access 4 Pages 2006
Inhibition of GABA shunt enzymes’ activity by 4-hydroxybenzaldehyde derivatives Fulltext Access 4 Pages 2006
Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power Fulltext Access 4 Pages 2006
Synthesis and antihyperglycemic evaluation of various protoberberine derivatives Fulltext Access 4 Pages 2006
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists Fulltext Access 4 Pages 2006
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers Fulltext Access 4 Pages 2006
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors Fulltext Access 4 Pages 2006
From pyrroles to pyrrolo[1,2-a]pyrazinones: A new class of mGluR1 antagonists Fulltext Access 4 Pages 2006
Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity Fulltext Access 4 Pages 2006
SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors Fulltext Access 4 Pages 2006
N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF—A significant increase in potency using per-O-acetylated sugar analogues Fulltext Access 4 Pages 2006
Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents Fulltext Access 4 Pages 2006
A novel class of sodium/calcium exchanger inhibitors: Design, synthesis, and structure–activity relationships of 4-phenyl-3-(piperidin-4-yl)-3,4-dihydro-2(1H)-quinazolinone derivatives Fulltext Access 4 Pages 2006
Synthesis and anti-microbial activity of pyrazolylbisindoles—Promising anti-fungal compounds Fulltext Access 4 Pages 2006
Study on synthesis and biological activity of a galactosylated piperazinyl porphyrin Fulltext Access 4 Pages 2006
3D QSAR studies of AChE inhibitors based on molecular docking scores and CoMFA Fulltext Access 4 Pages 2006
Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs Fulltext Access 4 Pages 2006
New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: High affinity ligands for the α1-adrenoceptor subtypes Fulltext Access 4 Pages 2006
Synthesis of antimicrobial 2,9,10-trisubstituted-6-oxo-7,12-dihydro-chromeno[3,4-b]quinoxalines Fulltext Access 4 Pages 2006
Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIα promoter and modulation of gene expression in cells Fulltext Access 4 Pages 2006
In vitro cytotoxicity of melleolide antibiotics: Structural and mechanistic aspects Fulltext Access 4 Pages 2006
Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium Fulltext Access 4 Pages 2006
Expedited SAR study of high-affinity ligands to the α2δ subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology Fulltext Access 4 Pages 2006
Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds Fulltext Access 4 Pages 2006
A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function Fulltext Access 4 Pages 2006
Molecular modeling analysis of the interaction of novel bis-cationic ligands with the lipid A moiety of lipopolysaccharide Fulltext Access 4 Pages 2006
Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation Fulltext Access 4 Pages 2006
Indoloprodigiosins from the C-10 bipyrrolic precursor: New antiproliferative prodigiosin analogs Fulltext Access 4 Pages 2006
Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase Fulltext Access 4 Pages 2006
A concise asymmetric route for the synthesis of a novel class of glucocorticoid mimetics containing a trifluoromethyl-substituted alcohol Fulltext Access 4 Pages 2006
Novel phenylamino acetamide derivatives as potent and selective κ opioid receptor agonists Fulltext Access 4 Pages 2006
The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase Fulltext Access 4 Pages 2006
Determination of furosemide in plasma and urine using monolithic silica rod liquid chromatography Fulltext Access 4 Pages 2006
Anti-cancer activities of 5-acyl-6-[2-hydroxy/benzyloxy-3-(amino)-propylamino]-1,3-dialkyl-1H-pyrimidin-2,4-diones Fulltext Access 4 Pages 2006
Inhibition of cellular proliferation by diterpenes, topoisomerase II inhibitor Fulltext Access 4 Pages 2006
Studies of interactions between uracil-based hybrid molecules and P-glycoprotein—Search for multidrug resistance modulators Fulltext Access 4 Pages 2006
Separation of nicotinic acid and its structural isomers using 1-ethyl-3-methylimidazolium ionic liquid as a buffer additive by capillary electrophoresis Fulltext Access 4 Pages 2006
High performance liquid chromatography assay method for simultaneous quantitation of formoterol and budesonide in Symbicort Turbuhaler Fulltext Access 4 Pages 2006
Determination of phenothiazine derivatives by high performance thin-layer chromatography combined with densitometry Fulltext Access 4 Pages 2006
Rapid determination of clindamycin in medicine with myoglobin-luminol chemiluminescence system Fulltext Access 4 Pages 2006
Determination of cefmetazole residue at pharmaceutical manufacturing facilities by chemiluminescence flow injection analysis Fulltext Access 4 Pages 2006
Determination of vincristine in infant plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy Fulltext Access 4 Pages 2006
Study of the interaction between rifapentine and isoniazid under acid conditions Fulltext Access 4 Pages 2006
Stability and degradation kinetics of meropenem in powder for injection and reconstituted sample Fulltext Access 4 Pages 2006
Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein Fulltext Access 4 Pages 2006
Isothermal titration calorimetry study of epicatechin binding to serum albumin Fulltext Access 4 Pages 2006
Effect of cooking on the concentration of Vitamins B in fortified meat products Fulltext Access 4 Pages 2006
Development and validation of a reversed-phase LC method for analysing potentially counterfeit antimalarial medicines Fulltext Access 4 Pages 2006
Application of monolithic column in quantification of gliclazide in human plasma by liquid chromatography Fulltext Access 4 Pages 2006
A simple and rapid liquid chromatographic assay for evaluation of potentially counterfeit Tamiflu® Fulltext Access 4 Pages 2006
CYP3A4 activity in four different animal species liver microsomes using 7-benzyloxyquinoline and HPLC/spectrofluorometric determination Fulltext Access 4 Pages 2006
A selective HPLC method for the determination of indapamide in human whole blood: Application to a bioequivalence study in Chinese volunteers Fulltext Access 4 Pages 2006
Quantitative determination of diterpenoid alkaloids in four species of Aconitum by HPLC Fulltext Access 4 Pages 2006
Color measurement of a solid active pharmaceutical ingredient as an aid to identifying key process parameters Fulltext Access 4 Pages 2006
Phenyl ureas of creatinine as mGluR5 antagonists. A structure–activity relationship study of fenobam analogues Fulltext Access 4 Pages 2006
CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect Fulltext Access 4 Pages 2006
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands Fulltext Access 4 Pages 2006
Synthesis and antitumor activity of simplified ecteinascidin–saframycin analogs Fulltext Access 4 Pages 2006
Effects of α-tocopherol and related compounds on reactions involving various organic radicals Fulltext Access 4 Pages 2006
Antiangiogenic activity of deoxoartemisinin derivatives on chorioallantoic membrane Fulltext Access 4 Pages 2006
The existence of a second allosteric site on the M1 muscarinic acetylcholine receptor and its implications for drug design Fulltext Access 4 Pages 2006
Gallium(III) complexes of methyl pyropheophorbide-a as synthetic models for investigation of diastereomerically controlled axial ligation towards chlorophylls Fulltext Access 4 Pages 2006
Synthesis and antimycobacterial activity of some alkyl [5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates Fulltext Access 4 Pages 2006
Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates Fulltext Access 4 Pages 2006
Structure–activity studies of quinuclidinone analogs as anti-proliferative agents in lung cancer cell lines Fulltext Access 4 Pages 2006
Packed column supercritical fluid chromatography of sodium stearyl fumarate aqueous suspension Fulltext Access 4 Pages 2006
Structure–activity relationships of α-amino acid ligands for the α2δ subunit of voltage-gated calcium channels Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: Potent and selective aromatase inhibitors Fulltext Access 4 Pages 2006
Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands Fulltext Access 4 Pages 2006
Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones Fulltext Access 4 Pages 2006
Design, synthesis and preliminary biological evaluations of novel amphiphilic drug carriers Fulltext Access 4 Pages 2006
Synthesis and monoamine transporter affinity of 2β-carbomethoxy-3β-(4′-p-substituted phenyl)-piperidine analogs of cocaine Fulltext Access 4 Pages 2006
A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure–activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346 Fulltext Access 4 Pages 2006
Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome Fulltext Access 4 Pages 2006
Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure–activity relationships Fulltext Access 4 Pages 2006
Chemo-enzymatic synthesis of 1,4-oxazepanyl sugar as potent inhibitor of chitinase Fulltext Access 4 Pages 2006
Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK Fulltext Access 4 Pages 2006