Novel indole inhibitors of IMPDH from fragments: Synthesis and initial structure–activity relationships Fulltext Access 4 Pages 2006
An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: Potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase Fulltext Access 4 Pages 2006
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1 Fulltext Access 4 Pages 2006
Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood–brain barrier Fulltext Access 4 Pages 2006
Synthesis and ocular effects of imidazole nitrolic acid and amidoxime esters Fulltext Access 4 Pages 2006
Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages Fulltext Access 4 Pages 2006
Synthesis of pyrazinamide Mannich bases and its antitubercular properties Fulltext Access 4 Pages 2006
Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2 Fulltext Access 4 Pages 2006
Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I Fulltext Access 4 Pages 2006
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: A novel agonist 5-HT1A receptor PET ligand Fulltext Access 4 Pages 2006
(R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis Fulltext Access 4 Pages 2006
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors Fulltext Access 4 Pages 2006
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase Fulltext Access 4 Pages 2006
Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation Fulltext Access 4 Pages 2006
Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow cytometry Fulltext Access 4 Pages 2006
A practical and green approach towards synthesis of dihydropyrimidinones: Using heteropoly acids as efficient catalysts Fulltext Access 4 Pages 2006
Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates Fulltext Access 4 Pages 2006
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats Fulltext Access 4 Pages 2006
Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter Fulltext Access 4 Pages 2006
Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: Variations on the 1H-pyrimidin-2-one theme Fulltext Access 4 Pages 2006
β-Diketo acids with purine nucleobase scaffolds: Novel, selective inhibitors of the strand transfer step of HIV integrase Fulltext Access 4 Pages 2006
A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273 Fulltext Access 4 Pages 2006
Synthesis of α-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors Fulltext Access 4 Pages 2006
Synthesis of constrained ceramide analogs and their potent antileukemic activities Fulltext Access 4 Pages 2006
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors Fulltext Access 4 Pages 2006
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase Fulltext Access 4 Pages 2006
Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities Fulltext Access 4 Pages 2006
Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors Fulltext Access 4 Pages 2006
How cyclodextrins can mask their toxic effect on the blood–brain barrier Fulltext Access 4 Pages 2006
Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility Fulltext Access 4 Pages 2006
Identification and structure–activity relationships of a new series of Melanocortin-4 receptor antagonists Fulltext Access 4 Pages 2006
Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities Fulltext Access 4 Pages 2006
β′-Hydroxy-α,β-unsaturated ketones: A new pharmacophore for the design of anticancer drugs Fulltext Access 4 Pages 2006
Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase Fulltext Access 4 Pages 2006
Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of dien and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline Fulltext Access 4 Pages 2006
Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors Fulltext Access 4 Pages 2006
New potential biologically active compounds: Design and an efficient synthesis of N-substituted 4-aryl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-diones under microwave irradiation Fulltext Access 4 Pages 2006
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists Fulltext Access 4 Pages 2006
The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists Fulltext Access 4 Pages 2006
Development of activity-based probes for trypsin-family serine proteases Fulltext Access 4 Pages 2006
Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction Fulltext Access 4 Pages 2006
Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 Fulltext Access 4 Pages 2006
p38 MAP kinase inhibitors. Part 5: Discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold Fulltext Access 4 Pages 2006
1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors Fulltext Access 4 Pages 2006
Chiral recognition by fluorescent chemosensors based on N-dansyl-amino acid-modified cyclodextrins Fulltext Access 4 Pages 2006
Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants Fulltext Access 4 Pages 2006
Synthesis of a novel ester analog of nucleic acids bearing a serine backbone Fulltext Access 4 Pages 2006
A new, efficient, and simple method for the one-pot synthesis of α-acetoxyphosphonates from aldehydes under solvent-free conditions Fulltext Access 4 Pages 2006
2-(3-Amino-3-deoxy-β-d-xylofuranosyl)thiazole-4-carboxamide: A new tiazofurin analogue with potent antitumour activity Fulltext Access 4 Pages 2006
Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases Fulltext Access 4 Pages 2006
A dual lanthanide probe suitable for optical (Tb3+ luminescence) and magnetic resonance imaging (Gd3+ relaxometry) Fulltext Access 4 Pages 2006
Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists Fulltext Access 4 Pages 2006
Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine l-ribonucleosides Fulltext Access 4 Pages 2006
Generating short peptidic ligands for silver nanowires from phage display random libraries Fulltext Access 4 Pages 2006
Intelligent fluorescent nucleoside in sensing cytosine base: Importance of hydrophobic nature of perylene fluorophore Fulltext Access 4 Pages 2006
Binding affinity prediction of non-peptide inhibitors of HIV-1 protease using COMBINE model introduced from peptide inhibitors Fulltext Access 4 Pages 2006
Zinc(II) and copper(II) complexes of β-substituted hydroxylporphyrins as tumor photosensitizers Fulltext Access 4 Pages 2006
α-Methylated derivatives of 2-arachidonoyl glycerol: Synthesis, CB1 receptor activity, and enzymatic stability Fulltext Access 4 Pages 2006
Synthesis of a bis-azido analogue of acromelic acid for radioisotope-free photoaffinity labeling and biochemical studies Fulltext Access 4 Pages 2006
Rapid high-throughput detection of peroxide with an acridinium-9-carboxamide: A homogeneous chemiluminescent assay for plasma choline Fulltext Access 4 Pages 2006
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity Fulltext Access 4 Pages 2006
The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases Fulltext Access 4 Pages 2006
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum Fulltext Access 4 Pages 2006
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents Fulltext Access 4 Pages 2006
Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A Fulltext Access 4 Pages 2006
Activation of mitogen activated protein kinase (MAPK) during d-galactosamine intoxication in the rat liver Fulltext Access 4 Pages 2006
Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging β-amyloid in Alzheimer’s disease Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors Fulltext Access 4 Pages 2006
Gatifloxacin derivatives: Synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase Fulltext Access 4 Pages 2006
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2α inhibitors Fulltext Access 4 Pages 2006
Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate Fulltext Access 4 Pages 2006
Functional organisation and gain of activity: The case of the antibacterial tetra-para-guanidinoethyl-calix[4]arene Fulltext Access 4 Pages 2006
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate synthase Fulltext Access 4 Pages 2006
Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia Fulltext Access 4 Pages 2006
Novel fluorescent probe for detecting hydroperoxides with strong emission in the visible range Fulltext Access 4 Pages 2006