Photoreactive threading agent that specifically binds to abasic sites in DNA Fulltext Access 4 Pages 2006
Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor Fulltext Access 4 Pages 2006
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor Fulltext Access 4 Pages 2006
New pyrrolopyrimidin-6-yl benzenesulfonamides: Potent A2B adenosine receptor antagonists Fulltext Access 4 Pages 2006
Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents Fulltext Access 4 Pages 2006
Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropanes Fulltext Access 4 Pages 2006
Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2 Fulltext Access 4 Pages 2006
Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists Fulltext Access 4 Pages 2006
Synthesis and preliminary biological evaluation of (2S,1â²R,2â²S)- and (2S,1â²S,2â²R)-2-(2â²-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues Fulltext Access 4 Pages 2006
New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists Fulltext Access 4 Pages 2006
Affinity identification of δ-opioid receptors using latex nanoparticles Fulltext Access 4 Pages 2006
Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives Fulltext Access 4 Pages 2006
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective α1-adrenoceptor ligands Fulltext Access 4 Pages 2006
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective δ-opioid agonists Fulltext Access 4 Pages 2006
The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs Fulltext Access 4 Pages 2006
New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies Fulltext Access 4 Pages 2006
Design and synthesis of downsized metastin (45–54) analogs with maintenance of high GPR54 agonistic activity Fulltext Access 4 Pages 2006
The design, synthesis, and evaluation of two universal doxorubicin-linkers: Preparation of conjugates that retain topoisomerase II activity Fulltext Access 4 Pages 2006
Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase Fulltext Access 4 Pages 2006
Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors Fulltext Access 4 Pages 2006
NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies Fulltext Access 4 Pages 2006
Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity Fulltext Access 4 Pages 2006
Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative Fulltext Access 4 Pages 2006
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase Fulltext Access 4 Pages 2006
Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD–NMR spectroscopy Fulltext Access 4 Pages 2006
Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: Impacting hERG liability via aryl modifications Fulltext Access 4 Pages 2006
Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors Fulltext Access 4 Pages 2006
Lactones from a brown alga endophytic fungus (No. ZZF36) from the South China Sea and their antimicrobial activities Fulltext Access 4 Pages 2006
Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors Fulltext Access 4 Pages 2006
Crystal structure, spectroscopic, and biological study of the copper(II) complex with third-generation quinolone antibiotic sparfloxacin Fulltext Access 4 Pages 2006
Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog Fulltext Access 4 Pages 2006
Privileged structure based ligands for melanocortin receptors—4,4-Disubstituted piperidine derivatives Fulltext Access 4 Pages 2006
3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity Fulltext Access 4 Pages 2006
Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates Fulltext Access 4 Pages 2006
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors Fulltext Access 4 Pages 2006
Nanomolar inhibition of the enterobactin biosynthesis enzyme, EntE: Synthesis, substituent effects, and additivity Fulltext Access 4 Pages 2006
Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors Fulltext Access 4 Pages 2006
Bivalent inhibitors of glutathione S-transferase: The effect of spacer length on isozyme selectivity Fulltext Access 4 Pages 2006
Evaluations of substrate specificity and inhibition at PR/p3 cleavage site of HTLV-1 protease Fulltext Access 4 Pages 2006
Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9 Fulltext Access 4 Pages 2006
Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP) Fulltext Access 4 Pages 2006
Design of cyclic peptides with agonist activity at melanocortin receptor-4 Fulltext Access 4 Pages 2006
4-Hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent Fulltext Access 4 Pages 2006
Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells Fulltext Access 4 Pages 2006
Stereoselective synthesis and glycosidase inhibitory activity of 3,4-dihydroxy-pyrrolidin-2-one, 3,4-dihydroxy-piperidin-2-one and 1,2-dihydroxy-pyrrolizidin-3-one Fulltext Access 4 Pages 2006
Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indoles Fulltext Access 4 Pages 2006
1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors Fulltext Access 4 Pages 2006
Synthesis and antibacterial activity of 9-substituted minocycline derivatives Fulltext Access 4 Pages 2006
Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase Fulltext Access 4 Pages 2006
Synthesis of N-benzylated-2-aminoquinolines as ligands for the Tec SH3 domain Fulltext Access 4 Pages 2006
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase Fulltext Access 4 Pages 2006
Biomimetic synthesis and ultrastructural characterization of a zerovalent gold–hydroxyapatite composite Fulltext Access 4 Pages 2006
Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile Fulltext Access 4 Pages 2006
Leptostatin: A synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B Fulltext Access 4 Pages 2006
A new chemical tool for exploring the physiological function of the PDE2 isozyme Fulltext Access 4 Pages 2006
Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility Fulltext Access 4 Pages 2006
Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors Fulltext Access 4 Pages 2006
Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative Fulltext Access 4 Pages 2006
Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease Fulltext Access 4 Pages 2006
Structure–activity relationship studies on UK-2A, a novel antifungal antibiotic from Streptomyces sp. 517-02. Part 5: Roles of the 9-membered dilactone-ring moiety in respiratory inhibition Fulltext Access 4 Pages 2006
Design, synthesis, and evaluation of novel kazusamycin A derivatives as potent antitumor agents Fulltext Access 4 Pages 2006
Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin Fulltext Access 4 Pages 2006
A new non-azole inhibitor of ABA 8′-hydroxylase: Effect of the hydroxyl group substituted for geminal methyl groups in the six-membered ring Fulltext Access 4 Pages 2006
1,1′-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: A new potential copper chelator agent for neuroprotection in Alzheimer’s disease. Its comparative effects with clioquinol on rat brain copper distribution Fulltext Access 4 Pages 2006
Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana Fulltext Access 4 Pages 2006
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: Towards synthetic epitope-based vaccines Fulltext Access 4 Pages 2006
High affinity inhibitors of the dopamine transporter (DAT): Novel biotinylated ligands for conjugation to quantum dots Fulltext Access 4 Pages 2006
The synthesis and nicotinic binding activity of (±)-epiquinamide and (±)-C(1)-epiepiquinamide Fulltext Access 4 Pages 2006
Synthesis and anticonvulsant activity of new N-1′,N-3′-disubstituted-2′H,3H,5′H-spiro-(2-benzofuran-1,4′-imidazolidine)-2′,3,5′-triones Fulltext Access 4 Pages 2006
Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation Fulltext Access 4 Pages 2006
3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors Fulltext Access 4 Pages 2006
Synthesis and molecular modeling of a lisinopril–tryptophan analogue inhibitor of angiotensin I-converting enzyme Fulltext Access 4 Pages 2006
Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors Fulltext Access 4 Pages 2006
A practical and green approach toward synthesis of N3-substituted dihydropyrimidinones: Using Aza-Michael addition reaction catalyzed by KF/Al2O3 Fulltext Access 4 Pages 2006
Synthesis and evaluation of phenoxy acetic acid derivatives as anti-mycobacterial agents Fulltext Access 4 Pages 2006
Stilbene-based anticancer agents: Resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism Fulltext Access 4 Pages 2006
N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1 Fulltext Access 4 Pages 2006
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) Fulltext Access 4 Pages 2006
An efficient one-pot synthesis of octahydroquinazolinone derivatives using catalytic amount of H2SO4 in water Fulltext Access 4 Pages 2006
Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5 Fulltext Access 4 Pages 2006
Structure of a new cyclic nonapeptide, segetalin F, and vasorelaxant activity of segetalins from Vaccaria segetalis Fulltext Access 4 Pages 2006
Selective COX-2 inhibitors. Part 1: Synthesis and biological evaluation of phenylazobenzenesulfonamides Fulltext Access 4 Pages 2006
Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase Fulltext Access 4 Pages 2006
Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins Fulltext Access 4 Pages 2006